Novel Suppressive Function of Transitional 2 B Cells in Experimental Arthritis

The immune system contains natural regulatory cells important in the maintenance of tolerance. Although this suppressive function is usually attributed to CD4 regulatory T cells, recent reports have revealed an immunoregulatory role for IL-10-producing B cells in the context of several autoimmune di...

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Veröffentlicht in:	Journal of Immunology 2007-06, Vol.178 (12), p.7868-7878
Hauptverfasser:	Evans, Jamie G, Chavez-Rueda, Karina A, Eddaoudi, Ayad, Meyer-Bahlburg, Almut, Rawlings, David J, Ehrenstein, Michael R, Mauri, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Arthritis, Experimental - immunology Arthritis, Experimental - pathology Arthritis, Experimental - prevention & control B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - transplantation B-Lymphocytes - immunology B-Lymphocytes - transplantation Collagen Type II - immunology Immune Tolerance Immunoglobulin M - metabolism Interferon-gamma - metabolism Interleukin-10 - metabolism Lymphocyte Activation Mice Phenotype Receptors, Complement 3d - metabolism Receptors, IgE - metabolism Th1 Cells - immunology
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