Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex

The mammalian cerebral cortex consists of six layers that are generated via coordinated neuronal migration during the embryonic period. Recent studies identified specific phases of radial migration of cortical neurons. After the final division, neurons transform from a multipolar to a bipolar shape...

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Veröffentlicht in:	Development (Cambridge) 2007-06, Vol.134 (12), p.2273-2282
Hauptverfasser:	Ohshima, Toshio, Hirasawa, Motoyuki, Tabata, Hidenori, Mutoh, Tetsuji, Adachi, Tomoko, Suzuki, Hiromi, Saruta, Keiko, Iwasato, Takuji, Itohara, Shigeyoshi, Hashimoto, Mistuhiro, Nakajima, Kazunori, Ogawa, Masaharu, Kulkarni, Ashok B, Mikoshiba, Katsuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Movement - physiology Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - embryology Cerebral Cortex - physiology Cyclin-Dependent Kinase 5 - genetics Cyclin-Dependent Kinase 5 - physiology Dendrites - physiology Electroporation In Situ Hybridization Mice Mice, Inbred ICR Mice, Knockout Mice, Neurologic Mutants Neurons - cytology Neurons - physiology Pyramidal Cells - embryology Pyramidal Cells - physiology
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