Functional Up-regulation of Human Leukocyte Antigen Class I Antigens Expression by 5-aza-2′-deoxycytidine in Cutaneous Melanoma: Immunotherapeutic Implications

Purpose: To investigate the potential of the DNA hypomethylating agent 5-aza-2′-deoxycytidine (5-aza-CdR) to improve the effectiveness of immunotherapeutic approaches against melanocyte differentiation antigens. Experimental Design: The effect of 5-aza-CdR on the constitutive expression of gp100 was...

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Veröffentlicht in:	Clinical cancer research 2007-06, Vol.13 (11), p.3333-3338
Hauptverfasser:	FONSATTI, Ester, NICOLAY, Hugues J. M, SIGALOTTI, Luca, CALABRO, Luana, PEZZANI, Laura, COLIZZI, Francesca, ALTOMONTE, Maresa, GUIDOBONI, Massimo, MARINCOLA, Francesco M, MAIO, Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	5-aza-2′deoxycytidine Antineoplastic agents Azacitidine - analogs & derivatives Azacitidine - pharmacology Biological and medical sciences Cell Line, Tumor Dermatology Fluorescent Antibody Technique, Indirect Gene Expression Regulation, Neoplastic gp100 gp100 Melanoma Antigen Histocompatibility Antigens Class I - biosynthesis HLA class I antigens Humans Immunotherapy - methods Intercellular adhesion molecule-1 Interferon-gamma - metabolism Medical sciences Melanoma Melanoma - drug therapy Melanoma - immunology Membrane Glycoproteins - metabolism Pharmacology. Drug treatments Reverse Transcriptase Polymerase Chain Reaction Skin Neoplasms - drug therapy Skin Neoplasms - immunology T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism Tumors of the skin and soft tissue. Premalignant lesions Up-Regulation
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