Serum amyloid P component and C-reactive protein mediate phagocytosis through murine Fc gamma Rs

The pentraxins, serum amyloid P component (SAP) and C-reactive protein (CRP) are acute-phase serum proteins in mice and humans, respectively. Although SAP binds to DNA and chromatin and affects clearance of these autoantigens, no specific receptor for SAP has been identified. CRP is an opsonin, and...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-01, Vol.166 (2), p.1200-1205
Hauptverfasser:	Mold, C, Gresham, H D, Du Clos, T W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - metabolism Adjuvants, Immunologic - physiology AFc receptors Animals Bone Marrow Cells - immunology Bone Marrow Cells - metabolism c-reactive protein C-Reactive Protein - metabolism C-Reactive Protein - physiology Cells, Cultured Dose-Response Relationship, Immunologic Humans Immunoglobulin gamma-Chains - biosynthesis Macrophages - immunology Macrophages - metabolism Male Mice Mice, Inbred C57BL Mice, Transgenic Opsonin Proteins - metabolism pentraxin Phagocytosis - immunology Protein Binding - immunology Receptors, IgG - physiology serum amyloid P Serum Amyloid P-Component - metabolism Serum Amyloid P-Component - physiology Zymosan - metabolism
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