Activation of muscarinic receptors reduces store-operated Ca2+ entry in HEK293 cells

In many cell types membrane receptors for hormones or neurotransmitters activate a signal transduction pathway which releases Ca2+ from intracellular Ca2+ stores by the second messenger inositol 1,4,5-trisphosphate. As a consequence store-operated Ca2+ entry (SOCE) becomes activated. In the present...

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Veröffentlicht in:	Cellular signalling 2007-07, Vol.19 (7), p.1457-1464
Hauptverfasser:	Sternfeld, Lutz, Dudenhöffer, Monika, Ludes, Anja, Heinze, Diana, Anderie, Ines, Krause, Elmar
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Calcium - metabolism Calcium Channel Blockers - pharmacology Calcium Signaling - drug effects Cell Line CHO Cells Cricetinae Cricetulus Cyclic AMP - metabolism Cytoplasm - drug effects Cytoplasm - metabolism Humans Muscarinic Agonists - pharmacology Receptors, Muscarinic - metabolism
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