Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats
It is well known that neuropeptide Y (NPY) and gamma-aminobutyric acid (GABA) exert antiepileptic effects in animal models. It has recently been shown that ghrelin neurons increase the activities of GABA and NPY in the brain. Therefore it can be said that ghrelin is an antiepileptic agent. In this s...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2007-06, Vol.28 (6), p.1214-1219 |
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| container_title | Peptides (New York, N.Y. : 1980) |
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| creator | Obay, Basra Deniz Tasdemir, Ezel Tümer, Cemil Bilgin, Hakkı Murat Sermet, Abdurrahman |
| description | It is well known that neuropeptide Y (NPY) and gamma-aminobutyric acid (GABA) exert antiepileptic effects in animal models. It has recently been shown that ghrelin neurons increase the activities of GABA and NPY in the brain. Therefore it can be said that ghrelin is an antiepileptic agent. In this study we aimed to investigate the antiepileptic effect of ghrelin in an acute experimental epilepsy model in pentylenetetrazole (PTZ) injected rats. Adult male Wistar albino rats were divided into a control group and four experimental groups with seven rats in each group. In order to generate epileptic seizures, PTZ (50
mg/kg) was injected intraperitoneally. The experimental groups received intraperitoneal injections of ghrelin at doses of 20, 40, 60 and 80
μg/kg 30
min before PTZ injection. After PTZ injection, the latencies were separated into three components: first myoclonic jerk, generalized clonic seizures and tonic generalized extension. The injection of 50
mg/kg PTZ-induced epileptic seizures in the control group. The onset times of the three characteristic behavioral changes were significantly delayed and the duration of tonic generalized extension was diminished by dose-dependent ghrelin administration. Our results demonstrated that ghrelin suppresses the onset time of PTZ-induced seizures. In the light of our current knowledge, it seems that ghrelin may be considered as an antiepileptic drug. |
| doi_str_mv | 10.1016/j.peptides.2007.04.003 |
| format | Article |
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mg/kg) was injected intraperitoneally. The experimental groups received intraperitoneal injections of ghrelin at doses of 20, 40, 60 and 80
μg/kg 30
min before PTZ injection. After PTZ injection, the latencies were separated into three components: first myoclonic jerk, generalized clonic seizures and tonic generalized extension. The injection of 50
mg/kg PTZ-induced epileptic seizures in the control group. The onset times of the three characteristic behavioral changes were significantly delayed and the duration of tonic generalized extension was diminished by dose-dependent ghrelin administration. Our results demonstrated that ghrelin suppresses the onset time of PTZ-induced seizures. In the light of our current knowledge, it seems that ghrelin may be considered as an antiepileptic drug.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/j.peptides.2007.04.003</identifier><identifier>PMID: 17512090</identifier><identifier>CODEN: PPTDD5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Anticonvulsants - pharmacology ; Anticonvulsants - therapeutic use ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Convulsants - pharmacology ; Dose-Response Relationship, Drug ; Epilepsy ; Fundamental and applied biological sciences. Psychology ; Ghrelin ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Injections, Intraperitoneal ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropharmacology ; Pentylenetetrazole (PTZ) ; Pentylenetetrazole - pharmacology ; Peptide Hormones - pharmacology ; Peptide Hormones - therapeutic use ; Pharmacology. Drug treatments ; Random Allocation ; Rats ; Rats, Wistar ; Seizures - drug therapy ; Time Factors ; Vertebrates: endocrinology</subject><ispartof>Peptides (New York, N.Y. : 1980), 2007-06, Vol.28 (6), p.1214-1219</ispartof><rights>2007 Elsevier Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-73ec7f589667ba4bef7d50b9624d9f38ca393844a61d3c5d0bc9640406db46723</citedby><cites>FETCH-LOGICAL-c462t-73ec7f589667ba4bef7d50b9624d9f38ca393844a61d3c5d0bc9640406db46723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0196978107001222$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18833377$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17512090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Obay, Basra Deniz</creatorcontrib><creatorcontrib>Tasdemir, Ezel</creatorcontrib><creatorcontrib>Tümer, Cemil</creatorcontrib><creatorcontrib>Bilgin, Hakkı Murat</creatorcontrib><creatorcontrib>Sermet, Abdurrahman</creatorcontrib><title>Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>It is well known that neuropeptide Y (NPY) and gamma-aminobutyric acid (GABA) exert antiepileptic effects in animal models. It has recently been shown that ghrelin neurons increase the activities of GABA and NPY in the brain. Therefore it can be said that ghrelin is an antiepileptic agent. In this study we aimed to investigate the antiepileptic effect of ghrelin in an acute experimental epilepsy model in pentylenetetrazole (PTZ) injected rats. Adult male Wistar albino rats were divided into a control group and four experimental groups with seven rats in each group. In order to generate epileptic seizures, PTZ (50
mg/kg) was injected intraperitoneally. The experimental groups received intraperitoneal injections of ghrelin at doses of 20, 40, 60 and 80
μg/kg 30
min before PTZ injection. After PTZ injection, the latencies were separated into three components: first myoclonic jerk, generalized clonic seizures and tonic generalized extension. The injection of 50
mg/kg PTZ-induced epileptic seizures in the control group. The onset times of the three characteristic behavioral changes were significantly delayed and the duration of tonic generalized extension was diminished by dose-dependent ghrelin administration. Our results demonstrated that ghrelin suppresses the onset time of PTZ-induced seizures. In the light of our current knowledge, it seems that ghrelin may be considered as an antiepileptic drug.</description><subject>Animals</subject><subject>Anticonvulsants - pharmacology</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Convulsants - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Epilepsy</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ghrelin</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Injections, Intraperitoneal</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Pentylenetetrazole (PTZ)</subject><subject>Pentylenetetrazole - pharmacology</subject><subject>Peptide Hormones - pharmacology</subject><subject>Peptide Hormones - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Seizures - drug therapy</subject><subject>Time Factors</subject><subject>Vertebrates: endocrinology</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MFu3CAQgGFUpWo2aV8h8qW52R0MBnNrFKVtpEi5tGeEYWhYebEDOFL26evVbpVjTly-mUE_IVcUGgpUfNs2M84lOMxNCyAb4A0A-0A2tJes7qhQZ2QDVIlayZ6ek4uctwDAueo_kXMqO9qCgg15vIkl4BzGwzZbofdoS64mX_19SjiGWE2xmjGW1xEjFizJ7KcR6xDdYtFVGcN-SZirVSZT8mfy0Zsx45fTe0n-_Lj7ffurfnj8eX9781BbLtpSS4ZW-q5XQsjB8AG9dB0MSrTcKc96a5hiPedGUMds52CwSnDgINzAhWzZJbk-7p3T9LxgLnoXssVxNBGnJWsJnVCSH6A4QpumnBN6PaewM-lVU9CHlHqr_6fUh5QauF5TroNXpwvLsEP3NnZqt4KvJ2CyNaNPJtqQ31zfM8akXN33o8O1x0vApLMNGNd6Ia2xtZvCe3_5BwRclm0</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Obay, Basra Deniz</creator><creator>Tasdemir, Ezel</creator><creator>Tümer, Cemil</creator><creator>Bilgin, Hakkı Murat</creator><creator>Sermet, Abdurrahman</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070601</creationdate><title>Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats</title><author>Obay, Basra Deniz ; Tasdemir, Ezel ; Tümer, Cemil ; Bilgin, Hakkı Murat ; Sermet, Abdurrahman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-73ec7f589667ba4bef7d50b9624d9f38ca393844a61d3c5d0bc9640406db46723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Anticonvulsants - pharmacology</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Convulsants - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Epilepsy</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ghrelin</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Injections, Intraperitoneal</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Pentylenetetrazole (PTZ)</topic><topic>Pentylenetetrazole - pharmacology</topic><topic>Peptide Hormones - pharmacology</topic><topic>Peptide Hormones - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Seizures - drug therapy</topic><topic>Time Factors</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Obay, Basra Deniz</creatorcontrib><creatorcontrib>Tasdemir, Ezel</creatorcontrib><creatorcontrib>Tümer, Cemil</creatorcontrib><creatorcontrib>Bilgin, Hakkı Murat</creatorcontrib><creatorcontrib>Sermet, Abdurrahman</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Obay, Basra Deniz</au><au>Tasdemir, Ezel</au><au>Tümer, Cemil</au><au>Bilgin, Hakkı Murat</au><au>Sermet, Abdurrahman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>28</volume><issue>6</issue><spage>1214</spage><epage>1219</epage><pages>1214-1219</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>It is well known that neuropeptide Y (NPY) and gamma-aminobutyric acid (GABA) exert antiepileptic effects in animal models. It has recently been shown that ghrelin neurons increase the activities of GABA and NPY in the brain. Therefore it can be said that ghrelin is an antiepileptic agent. In this study we aimed to investigate the antiepileptic effect of ghrelin in an acute experimental epilepsy model in pentylenetetrazole (PTZ) injected rats. Adult male Wistar albino rats were divided into a control group and four experimental groups with seven rats in each group. In order to generate epileptic seizures, PTZ (50
mg/kg) was injected intraperitoneally. The experimental groups received intraperitoneal injections of ghrelin at doses of 20, 40, 60 and 80
μg/kg 30
min before PTZ injection. After PTZ injection, the latencies were separated into three components: first myoclonic jerk, generalized clonic seizures and tonic generalized extension. The injection of 50
mg/kg PTZ-induced epileptic seizures in the control group. The onset times of the three characteristic behavioral changes were significantly delayed and the duration of tonic generalized extension was diminished by dose-dependent ghrelin administration. Our results demonstrated that ghrelin suppresses the onset time of PTZ-induced seizures. In the light of our current knowledge, it seems that ghrelin may be considered as an antiepileptic drug.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17512090</pmid><doi>10.1016/j.peptides.2007.04.003</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 2007-06, Vol.28 (6), p.1214-1219 |
| issn | 0196-9781 1873-5169 |
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| subjects | Animals Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Convulsants - pharmacology Dose-Response Relationship, Drug Epilepsy Fundamental and applied biological sciences. Psychology Ghrelin Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Injections, Intraperitoneal Male Medical sciences Nervous system (semeiology, syndromes) Neurology Neuropharmacology Pentylenetetrazole (PTZ) Pentylenetetrazole - pharmacology Peptide Hormones - pharmacology Peptide Hormones - therapeutic use Pharmacology. Drug treatments Random Allocation Rats Rats, Wistar Seizures - drug therapy Time Factors Vertebrates: endocrinology |
| title | Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats |
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