Preoperative diagnosis of intraductal papillary‐mucinous tumors of the pancreas with attention to telomerase activity
BACKGROUND It has been reported that, in patients with intraductal papillary‐mucinous tumor (IPMT) of the pancreas, it is difficult to distinguish adenoma from carcinoma preoperatively. Recently, it has also been reported that telomerase activity was detected in many patients with carcinoma. In this...
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| Veröffentlicht in: | Cancer 2001-01, Vol.91 (1), p.35-41 |
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| creator | Inoue, Hiroki Tsuchida, Akira Kawasaki, Yousuke Fujimoto, Yoshifumi Yamasaki, Souichirou Kajiyama, Goro |
| description | BACKGROUND
It has been reported that, in patients with intraductal papillary‐mucinous tumor (IPMT) of the pancreas, it is difficult to distinguish adenoma from carcinoma preoperatively. Recently, it has also been reported that telomerase activity was detected in many patients with carcinoma. In this report, the authors used the method of telomerase repeat amplification protocol (TRAP) assay on pancreatic juice retrieved by endoscopic retrograde pancreatic juice aspiration (ERP aspiration).
METHODS
Pancreatic juice was collected from 28 patients (13 with intraductal carcinoma and 15 with adenoma) using ERP aspiration at either Hiroshima University Hospital or its affiliated hospitals. Two samples of pancreatic juice were collected from each patient. Each sample was examined by cytology for Papanicolaou staining and TRAP assay.
RESULTS
Four of 13 IPMT patients (31%) with intraductal carcinoma were diagnosed accurately by cytology. Seven of nine patients who were classified with benign tumors by cytologic assessment had tumors that expressed telomerase activity. Overall, 11 of 13 IPMT patients (85%) with intraductal carcinoma were diagnosed correctly by cytology associated with telomerase activity. All of the IPMT patients with adenoma were classified with benign tumors by cytologic assessment, and telomerase activity was not expressed.
CONCLUSIONS
In this study, the authors found that telomerase activity was expressed with a comparatively high probability in intraductal carcinoma. These results suggest that telomerase activity in pancreatic juices may be used as an adjunct to cytologic diagnosis and may aid further in distinguishing between benign IPMT and malignant IPMT of the pancreas preoperatively. Cancer 2001;91:35–41. © 2001 American Cancer Society.
Telomerase activity using pancreatic juice is more accurate than conventional cytologic examination in differentiating adenoma from carcinoma of intraductal papillary‐mucinous tumor of the pancreas. |
| doi_str_mv | 10.1002/1097-0142(20010101)91:1<35::AID-CNCR5>3.0.CO;2-A |
| format | Article |
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It has been reported that, in patients with intraductal papillary‐mucinous tumor (IPMT) of the pancreas, it is difficult to distinguish adenoma from carcinoma preoperatively. Recently, it has also been reported that telomerase activity was detected in many patients with carcinoma. In this report, the authors used the method of telomerase repeat amplification protocol (TRAP) assay on pancreatic juice retrieved by endoscopic retrograde pancreatic juice aspiration (ERP aspiration).
METHODS
Pancreatic juice was collected from 28 patients (13 with intraductal carcinoma and 15 with adenoma) using ERP aspiration at either Hiroshima University Hospital or its affiliated hospitals. Two samples of pancreatic juice were collected from each patient. Each sample was examined by cytology for Papanicolaou staining and TRAP assay.
RESULTS
Four of 13 IPMT patients (31%) with intraductal carcinoma were diagnosed accurately by cytology. Seven of nine patients who were classified with benign tumors by cytologic assessment had tumors that expressed telomerase activity. Overall, 11 of 13 IPMT patients (85%) with intraductal carcinoma were diagnosed correctly by cytology associated with telomerase activity. All of the IPMT patients with adenoma were classified with benign tumors by cytologic assessment, and telomerase activity was not expressed.
CONCLUSIONS
In this study, the authors found that telomerase activity was expressed with a comparatively high probability in intraductal carcinoma. These results suggest that telomerase activity in pancreatic juices may be used as an adjunct to cytologic diagnosis and may aid further in distinguishing between benign IPMT and malignant IPMT of the pancreas preoperatively. Cancer 2001;91:35–41. © 2001 American Cancer Society.
Telomerase activity using pancreatic juice is more accurate than conventional cytologic examination in differentiating adenoma from carcinoma of intraductal papillary‐mucinous tumor of the pancreas.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(20010101)91:1<35::AID-CNCR5>3.0.CO;2-A</identifier><identifier>PMID: 11148557</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adenocarcinoma, Mucinous - diagnosis ; Adenocarcinoma, Mucinous - enzymology ; Adenocarcinoma, Mucinous - pathology ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Biomarkers, Tumor - metabolism ; Carcinoma, Pancreatic Ductal - diagnosis ; Carcinoma, Pancreatic Ductal - enzymology ; Carcinoma, Pancreatic Ductal - pathology ; Carcinoma, Papillary - diagnosis ; Carcinoma, Papillary - enzymology ; Carcinoma, Papillary - pathology ; Diagnosis, Differential ; endoscopic retrograde pancreatic juice aspiration ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; intraductal papillary‐mucinous tumor of the pancreas ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; malignant ; Medical sciences ; Middle Aged ; Nucleic Acid Amplification Techniques ; Pancreatic Juice - chemistry ; Pancreatic Neoplasms - diagnosis ; Pancreatic Neoplasms - enzymology ; Pancreatic Neoplasms - pathology ; Preoperative Care ; Telomerase - analysis ; Telomerase - metabolism ; telomerase activity ; Tumors</subject><ispartof>Cancer, 2001-01, Vol.91 (1), p.35-41</ispartof><rights>Copyright © 2001 American Cancer Society</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2001 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4565-940a3fd9d3699b5ca45f9679d1d7f96de8e2f85089c120f97bc3537a74cd84123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F1097-0142%2820010101%2991%3A1%3C35%3A%3AAID-CNCR5%3E3.0.CO%3B2-A$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F1097-0142%2820010101%2991%3A1%3C35%3A%3AAID-CNCR5%3E3.0.CO%3B2-A$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,4010,27900,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=916885$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11148557$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inoue, Hiroki</creatorcontrib><creatorcontrib>Tsuchida, Akira</creatorcontrib><creatorcontrib>Kawasaki, Yousuke</creatorcontrib><creatorcontrib>Fujimoto, Yoshifumi</creatorcontrib><creatorcontrib>Yamasaki, Souichirou</creatorcontrib><creatorcontrib>Kajiyama, Goro</creatorcontrib><title>Preoperative diagnosis of intraductal papillary‐mucinous tumors of the pancreas with attention to telomerase activity</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
It has been reported that, in patients with intraductal papillary‐mucinous tumor (IPMT) of the pancreas, it is difficult to distinguish adenoma from carcinoma preoperatively. Recently, it has also been reported that telomerase activity was detected in many patients with carcinoma. In this report, the authors used the method of telomerase repeat amplification protocol (TRAP) assay on pancreatic juice retrieved by endoscopic retrograde pancreatic juice aspiration (ERP aspiration).
METHODS
Pancreatic juice was collected from 28 patients (13 with intraductal carcinoma and 15 with adenoma) using ERP aspiration at either Hiroshima University Hospital or its affiliated hospitals. Two samples of pancreatic juice were collected from each patient. Each sample was examined by cytology for Papanicolaou staining and TRAP assay.
RESULTS
Four of 13 IPMT patients (31%) with intraductal carcinoma were diagnosed accurately by cytology. Seven of nine patients who were classified with benign tumors by cytologic assessment had tumors that expressed telomerase activity. Overall, 11 of 13 IPMT patients (85%) with intraductal carcinoma were diagnosed correctly by cytology associated with telomerase activity. All of the IPMT patients with adenoma were classified with benign tumors by cytologic assessment, and telomerase activity was not expressed.
CONCLUSIONS
In this study, the authors found that telomerase activity was expressed with a comparatively high probability in intraductal carcinoma. These results suggest that telomerase activity in pancreatic juices may be used as an adjunct to cytologic diagnosis and may aid further in distinguishing between benign IPMT and malignant IPMT of the pancreas preoperatively. Cancer 2001;91:35–41. © 2001 American Cancer Society.
Telomerase activity using pancreatic juice is more accurate than conventional cytologic examination in differentiating adenoma from carcinoma of intraductal papillary‐mucinous tumor of the pancreas.</description><subject>Adenocarcinoma, Mucinous - diagnosis</subject><subject>Adenocarcinoma, Mucinous - enzymology</subject><subject>Adenocarcinoma, Mucinous - pathology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Pancreatic Ductal - diagnosis</subject><subject>Carcinoma, Pancreatic Ductal - enzymology</subject><subject>Carcinoma, Pancreatic Ductal - pathology</subject><subject>Carcinoma, Papillary - diagnosis</subject><subject>Carcinoma, Papillary - enzymology</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Diagnosis, Differential</subject><subject>endoscopic retrograde pancreatic juice aspiration</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>intraductal papillary‐mucinous tumor of the pancreas</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>malignant</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nucleic Acid Amplification Techniques</subject><subject>Pancreatic Juice - chemistry</subject><subject>Pancreatic Neoplasms - diagnosis</subject><subject>Pancreatic Neoplasms - enzymology</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Preoperative Care</subject><subject>Telomerase - analysis</subject><subject>Telomerase - metabolism</subject><subject>telomerase activity</subject><subject>Tumors</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkd9qFDEUxoModq2-ggQE0YtZk8lkZrIVYRlbLRS3FAXvDtkkYyMzkzHJuOydj-Az9kma7a71xhvJRf7wy3fO-T6EakrmlJD8DSWiyggt8lc5IXS3Xgu6oG8ZXyyW5--z5lNzxd-xOZk3q5M8Wz5As_svD9GMEFJnvGBfj9CTEL6na5Vz9hgdUUqLmvNqhjaX3rjReBntT4O1ld8GF2zArsV2iF7qSUXZ4VGOtuuk3978-t1Pyg5uCjhOvfN3aLw2CRmUNzLgjY3XWMZohmjdgKPD0XSuTzWCwVKlQjZun6JHreyCeXbYj9GXs9PPzcfsYvXhvFleZKrgJc9EQSRrtdCsFGLNlSx4K8pKaKqrdNCmNnlbc1ILRXPSimqtGGeVrAql64Lm7Bi93OuO3v2YTIjQ26BMmmUwaQaoCC8FK0QCL_eg8i4Eb1oYve3TxEAJ7MKAnbOwcxb-hAGCAgXGAVIYcBcGMCDQrCCHZZJ8fqg9rXuj_woe3E_AiwMgg5Jd65OFNtxzgpZ1zRN1tac2tjPb_2nrX13tH9gt0M-yIw</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>Inoue, Hiroki</creator><creator>Tsuchida, Akira</creator><creator>Kawasaki, Yousuke</creator><creator>Fujimoto, Yoshifumi</creator><creator>Yamasaki, Souichirou</creator><creator>Kajiyama, Goro</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010101</creationdate><title>Preoperative diagnosis of intraductal papillary‐mucinous tumors of the pancreas with attention to telomerase activity</title><author>Inoue, Hiroki ; Tsuchida, Akira ; Kawasaki, Yousuke ; Fujimoto, Yoshifumi ; Yamasaki, Souichirou ; Kajiyama, Goro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4565-940a3fd9d3699b5ca45f9679d1d7f96de8e2f85089c120f97bc3537a74cd84123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adenocarcinoma, Mucinous - diagnosis</topic><topic>Adenocarcinoma, Mucinous - enzymology</topic><topic>Adenocarcinoma, Mucinous - pathology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Pancreatic Ductal - diagnosis</topic><topic>Carcinoma, Pancreatic Ductal - enzymology</topic><topic>Carcinoma, Pancreatic Ductal - pathology</topic><topic>Carcinoma, Papillary - diagnosis</topic><topic>Carcinoma, Papillary - enzymology</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Diagnosis, Differential</topic><topic>endoscopic retrograde pancreatic juice aspiration</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>intraductal papillary‐mucinous tumor of the pancreas</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>malignant</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nucleic Acid Amplification Techniques</topic><topic>Pancreatic Juice - chemistry</topic><topic>Pancreatic Neoplasms - diagnosis</topic><topic>Pancreatic Neoplasms - enzymology</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Preoperative Care</topic><topic>Telomerase - analysis</topic><topic>Telomerase - metabolism</topic><topic>telomerase activity</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inoue, Hiroki</creatorcontrib><creatorcontrib>Tsuchida, Akira</creatorcontrib><creatorcontrib>Kawasaki, Yousuke</creatorcontrib><creatorcontrib>Fujimoto, Yoshifumi</creatorcontrib><creatorcontrib>Yamasaki, Souichirou</creatorcontrib><creatorcontrib>Kajiyama, Goro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inoue, Hiroki</au><au>Tsuchida, Akira</au><au>Kawasaki, Yousuke</au><au>Fujimoto, Yoshifumi</au><au>Yamasaki, Souichirou</au><au>Kajiyama, Goro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative diagnosis of intraductal papillary‐mucinous tumors of the pancreas with attention to telomerase activity</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2001-01-01</date><risdate>2001</risdate><volume>91</volume><issue>1</issue><spage>35</spage><epage>41</epage><pages>35-41</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
It has been reported that, in patients with intraductal papillary‐mucinous tumor (IPMT) of the pancreas, it is difficult to distinguish adenoma from carcinoma preoperatively. Recently, it has also been reported that telomerase activity was detected in many patients with carcinoma. In this report, the authors used the method of telomerase repeat amplification protocol (TRAP) assay on pancreatic juice retrieved by endoscopic retrograde pancreatic juice aspiration (ERP aspiration).
METHODS
Pancreatic juice was collected from 28 patients (13 with intraductal carcinoma and 15 with adenoma) using ERP aspiration at either Hiroshima University Hospital or its affiliated hospitals. Two samples of pancreatic juice were collected from each patient. Each sample was examined by cytology for Papanicolaou staining and TRAP assay.
RESULTS
Four of 13 IPMT patients (31%) with intraductal carcinoma were diagnosed accurately by cytology. Seven of nine patients who were classified with benign tumors by cytologic assessment had tumors that expressed telomerase activity. Overall, 11 of 13 IPMT patients (85%) with intraductal carcinoma were diagnosed correctly by cytology associated with telomerase activity. All of the IPMT patients with adenoma were classified with benign tumors by cytologic assessment, and telomerase activity was not expressed.
CONCLUSIONS
In this study, the authors found that telomerase activity was expressed with a comparatively high probability in intraductal carcinoma. These results suggest that telomerase activity in pancreatic juices may be used as an adjunct to cytologic diagnosis and may aid further in distinguishing between benign IPMT and malignant IPMT of the pancreas preoperatively. Cancer 2001;91:35–41. © 2001 American Cancer Society.
Telomerase activity using pancreatic juice is more accurate than conventional cytologic examination in differentiating adenoma from carcinoma of intraductal papillary‐mucinous tumor of the pancreas.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11148557</pmid><doi>10.1002/1097-0142(20010101)91:1<35::AID-CNCR5>3.0.CO;2-A</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma, Mucinous - diagnosis Adenocarcinoma, Mucinous - enzymology Adenocarcinoma, Mucinous - pathology Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Carcinoma, Pancreatic Ductal - diagnosis Carcinoma, Pancreatic Ductal - enzymology Carcinoma, Pancreatic Ductal - pathology Carcinoma, Papillary - diagnosis Carcinoma, Papillary - enzymology Carcinoma, Papillary - pathology Diagnosis, Differential endoscopic retrograde pancreatic juice aspiration Female Gastroenterology. Liver. Pancreas. Abdomen Humans intraductal papillary‐mucinous tumor of the pancreas Liver. Biliary tract. Portal circulation. Exocrine pancreas Male malignant Medical sciences Middle Aged Nucleic Acid Amplification Techniques Pancreatic Juice - chemistry Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - enzymology Pancreatic Neoplasms - pathology Preoperative Care Telomerase - analysis Telomerase - metabolism telomerase activity Tumors |
| title | Preoperative diagnosis of intraductal papillary‐mucinous tumors of the pancreas with attention to telomerase activity |
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