New chemotactic dimeric peptides show high affinity and potency at the human formylpeptide receptor

A number of analogues of the prototypical peptide for-Met-Leu-Phe-OMe (fMLP-OMe) have been studied in order to evaluate their ability to interact with formylpeptide receptors and to induce specific biological responses in human neutrophils. In vitro assays were carried out and receptor binding, chem...

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Veröffentlicht in:	European journal of pharmacology 2007-07, Vol.567 (1), p.171-176
Hauptverfasser:	Spisani, Susanna, Fraulini, Anna, Varani, Katia, Falzarano, Sofia, Cavicchioni, Giorgio
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids, Neutral - chemistry Aminocaproic Acid - chemistry Binding, Competitive Biological and medical sciences Chemotaxis Chemotaxis, Leukocyte - drug effects Dimerization gamma-Aminobutyric Acid - chemistry Human neutrophil Humans In Vitro Techniques Lysosomes - enzymology Lysozyme release Medical sciences N-Formylmethionine Leucyl-Phenylalanine - analogs & derivatives N-Formylmethionine Leucyl-Phenylalanine - chemical synthesis N-Formylmethionine Leucyl-Phenylalanine - chemistry N-Formylmethionine Leucyl-Phenylalanine - pharmacology N-formylmethionyl peptide Neutrophils - drug effects Neutrophils - physiology Pharmacology. Drug treatments Radioligand Assay Receptor binding Receptors, Formyl Peptide - agonists Structure-Activity Relationship Superoxide anion generation Superoxides - metabolism
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