Spontaneous Transformation of Human Adult Nontumorigenic Stem Cells to Cancer Stem Cells Is Driven by Genomic Instability in a Human Model of Glioblastoma

The presence of a CD133+/nestin+ population in brain tumors suggests that a normal neural stem cell may be the cell of origin for gliomas. We have identified human CD133‐positive NSCs from adult glioma tissue and established them as long‐term in vitro cultures human neuroglial culture (HNGC)‐1. Repl...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2007-06, Vol.25 (6), p.1478-1489
Hauptverfasser:	Shiras, Anjali, Chettiar, Sivarajan T, Shepal, Varsha, Rajendran, Ganeshkumar, Prasad, G. Rajendra, Shastry, Padma
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult stem cell transformation Adult Stem Cells - pathology Animals Brain Neoplasms - genetics Brain Neoplasms - pathology Cancer stem cells Cell Proliferation Cell Transformation, Neoplastic - genetics Cellular Senescence - genetics Genomic instability Genomic Instability - physiology Glioblastoma Glioblastoma - genetics Glioblastoma - pathology Humans Mice Mice, Nude Models, Biological Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Neoplastic Stem Cells - enzymology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Neural stem cells Spontaneous immortalization Telomerase - metabolism Tumor Cells, Cultured
Online-Zugang:	Volltext
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