Genetic Variation in H2AFX Contributes to Risk of Non–Hodgkin Lymphoma

Non–Hodgkin lymphoma (NHL) comprises a group of lymphoid tumors that have in common somatic translocations. H2AFX encodes a key histone involved in the detection of the DNA double-stranded breaks that can lead to translocations. H2afx is a dosage-dependent gene that protects against B-cell lymphomas...

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Veröffentlicht in:	Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2007-06, Vol.16 (6), p.1098-1106
Hauptverfasser:	NOVIK, Karen L, SPINELLI, John J, BROOKS-WILSON, Angela R, MACARTHUR, Amy C, SHUMANSKY, Karey, SIPAHIMALANI, Payal, LEACH, Stephen, LAI, Agnes, CONNORS, Joseph M, GASCOYNE, Randy D, GALLAGHER, Richard P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Base Sequence Biological and medical sciences Biological Evolution Case-Control Studies Female Genetic Predisposition to Disease genetic susceptibility Genotype H2AFX Hematologic and hematopoietic diseases Histones - genetics Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Linkage Disequilibrium Lymphoma, Non-Hodgkin - genetics Male Medical sciences Middle Aged Molecular Sequence Data non–Hodgkin's lymphoma Polymerase Chain Reaction Polymorphism, Single Nucleotide Risk Factors Sequence Homology, Nucleic Acid single nucleotide polymorphism SNP Tumors
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