The influence of the age in the risk of the prothrombin G20210A mutation for spontaneous venous thrombosis
Factor V Leiden mutation (FVL), and the prothrombin G20210A mutation (PT G20210A) are polymorphisms with a weak risk factor for venous thromboembolic disease. The probability of spontaneous venous thrombosis in carriers of thrombophilic mutations (FVL and PT G20210A) was analyzed. We studied 735 ind...
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| Veröffentlicht in: | Medicina clínica 2007-05, Vol.128 (17), p.652-654 |
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| creator | Reyes Gutiérrez Tous, María Couto Caro, Carmen García-Donas Gabaldón, Gloria del Mar Viloria Peñas, María Simón Pilo, Isabel Almeida González, Carmen |
| description | Factor V Leiden mutation (FVL), and the prothrombin G20210A mutation (PT G20210A) are polymorphisms with a weak risk factor for venous thromboembolic disease. The probability of spontaneous venous thrombosis in carriers of thrombophilic mutations (FVL and PT G20210A) was analyzed.
We studied 735 individuals (407 were healthy controls and 328 patients with venous thrombosis) with respect to FVL and PT G20210A, determined by polimerase chain reaction in liquid phase, real time. χ
2 test and logistic regression analysis were used to evaluate the results. The dates were analyzed with the statistical program SPSS v. 14.0.
The carrier patients of PT G20210A mutation whose age was over 40 years had a risk factor for spontaneous venous thrombosis which was 9.28 (odds ratio [OR]) (95% confidence interval [CI], 3.01-28.60; p
<
0.0005) times greater than carriers of the PT G20210A mutation who were 40 year-old or younger. In our patients, being male meant a weak risk factor for venous spontaneous thrombosis (p
=
0.021; OR
=
1.64; 95% CI, 1.08-2.51).
Our results demonstrate a potentiation of the thrombotic risk by an increase of age in the carriers of the PT G20210A mutation.
El factor V Leiden (FVL) y la mutación de la protrombina G20210A (PT G20210A) son unos polimorfismos que suponen un débil factor de riesgo para presentar enfermedad tromboembólica venosa. Hemos analizado la probabilidad de tener una trombosis venosa espontánea en los portadores de las mutaciones trombofílicas (FVL y PT G20210A).
Hemos estudiado a 735 personas (407 controles sanos y 328 pacientes con trombosis venosa) con relación al FVL y a la PT G20210A, determinados por reacción en cadena de la polimerasa en fase líquida, en tiempo real. Para evaluar los resultados utilizamos el test de la χ
2 y el análisis de regresión logística. Los datos se analizaron con el programa estadístico SPSS versión 14.0.
Los pacientes con la mutación PT G20210A que eran mayores de 40 años tuvieron un factor de riesgo para trombosis venosa espontánea con una
odds ratio (OR) 9,28 (intervalo de confianza (IC) del 95%, 3,01- 28,60; p
<
0,0005) veces mayor que los portadores de la mutación PT G20210A que tenían 40 años o menos. En nuestra serie el sexo masculino representó un factor de riesgo débil para trombosis venosa espontánea (p
=
0,021; OR
=
1,64; IC del 95%, 1,08-2,51).
Nuestros resultados demuestran una potenciación del riesgo trombótico por el incremento de la edad en los individuos portadores de la mutación PT |
| doi_str_mv | 10.1157/13102051 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70567914</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0025775307726830</els_id><sourcerecordid>70567914</sourcerecordid><originalsourceid>FETCH-LOGICAL-c285t-3b25645fa0bf83e397c4f9f2591f13965b9453da8ad23d1119e14db834bcf9f33</originalsourceid><addsrcrecordid>eNplkDFPwzAQhT2AaClI_AKUCbEEfHacNGNVQUGqxFJmy3Fs6pLExXYq8e9xSCsGpju_-_x09xC6AfwAwIpHoIAJZnCGphgTlhYFoxN06f1ueFIoLtAEolbQnEzRbrNViel006tOqsTqJERBfAzib-uM_zzJe2fD1tm2irMVwQTwImn7IIKxXaKtS_zedkF0yvY-OahuKOMH642_QudaNF5dH-sMvT8_bZYv6fpt9bpcrFNJ5iyktCIsz5gWuNJzqmhZyEyXmrASNNAyZ1WZMVqLuagJrQGgVJDV1ZxmlYwcpTN0N_rGdb965QNvjZeqacbFeIFZXpSQRfB-BKWz3jul-d6ZVrhvDpgPWfJTlhG9PXr2VavqP_AYZATICKh42cEox700Q6S1cUoGXlvz3_UHet2AaA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70567914</pqid></control><display><type>article</type><title>The influence of the age in the risk of the prothrombin G20210A mutation for spontaneous venous thrombosis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Reyes Gutiérrez Tous, María ; Couto Caro, Carmen ; García-Donas Gabaldón, Gloria ; del Mar Viloria Peñas, María ; Simón Pilo, Isabel ; Almeida González, Carmen</creator><creatorcontrib>Reyes Gutiérrez Tous, María ; Couto Caro, Carmen ; García-Donas Gabaldón, Gloria ; del Mar Viloria Peñas, María ; Simón Pilo, Isabel ; Almeida González, Carmen</creatorcontrib><description>Factor V Leiden mutation (FVL), and the prothrombin G20210A mutation (PT G20210A) are polymorphisms with a weak risk factor for venous thromboembolic disease. The probability of spontaneous venous thrombosis in carriers of thrombophilic mutations (FVL and PT G20210A) was analyzed.
We studied 735 individuals (407 were healthy controls and 328 patients with venous thrombosis) with respect to FVL and PT G20210A, determined by polimerase chain reaction in liquid phase, real time. χ
2 test and logistic regression analysis were used to evaluate the results. The dates were analyzed with the statistical program SPSS v. 14.0.
The carrier patients of PT G20210A mutation whose age was over 40 years had a risk factor for spontaneous venous thrombosis which was 9.28 (odds ratio [OR]) (95% confidence interval [CI], 3.01-28.60; p
<
0.0005) times greater than carriers of the PT G20210A mutation who were 40 year-old or younger. In our patients, being male meant a weak risk factor for venous spontaneous thrombosis (p
=
0.021; OR
=
1.64; 95% CI, 1.08-2.51).
Our results demonstrate a potentiation of the thrombotic risk by an increase of age in the carriers of the PT G20210A mutation.
El factor V Leiden (FVL) y la mutación de la protrombina G20210A (PT G20210A) son unos polimorfismos que suponen un débil factor de riesgo para presentar enfermedad tromboembólica venosa. Hemos analizado la probabilidad de tener una trombosis venosa espontánea en los portadores de las mutaciones trombofílicas (FVL y PT G20210A).
Hemos estudiado a 735 personas (407 controles sanos y 328 pacientes con trombosis venosa) con relación al FVL y a la PT G20210A, determinados por reacción en cadena de la polimerasa en fase líquida, en tiempo real. Para evaluar los resultados utilizamos el test de la χ
2 y el análisis de regresión logística. Los datos se analizaron con el programa estadístico SPSS versión 14.0.
Los pacientes con la mutación PT G20210A que eran mayores de 40 años tuvieron un factor de riesgo para trombosis venosa espontánea con una
odds ratio (OR) 9,28 (intervalo de confianza (IC) del 95%, 3,01- 28,60; p
<
0,0005) veces mayor que los portadores de la mutación PT G20210A que tenían 40 años o menos. En nuestra serie el sexo masculino representó un factor de riesgo débil para trombosis venosa espontánea (p
=
0,021; OR
=
1,64; IC del 95%, 1,08-2,51).
Nuestros resultados demuestran una potenciación del riesgo trombótico por el incremento de la edad en los individuos portadores de la mutación PT G20210A.</description><identifier>ISSN: 0025-7753</identifier><identifier>DOI: 10.1157/13102051</identifier><identifier>PMID: 17537362</identifier><language>eng</language><publisher>Spain: Elsevier Espana</publisher><subject>Age Factors ; Case-Control Studies ; Enfermedad tromoboembólica ; Factor de riesgo ; Factor V Leiden ; Female ; Humans ; Male ; Middle Aged ; Mutation ; Prospective Studies ; Prothrombin - genetics ; Prothrombin G20210A ; Protrombina G20210A ; Risk factor ; Risk Factors ; Thromboembolism disease ; Venous Thrombosis - genetics</subject><ispartof>Medicina clínica, 2007-05, Vol.128 (17), p.652-654</ispartof><rights>2007 Elsevier España S.L.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c285t-3b25645fa0bf83e397c4f9f2591f13965b9453da8ad23d1119e14db834bcf9f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0025775307726830$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17537362$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reyes Gutiérrez Tous, María</creatorcontrib><creatorcontrib>Couto Caro, Carmen</creatorcontrib><creatorcontrib>García-Donas Gabaldón, Gloria</creatorcontrib><creatorcontrib>del Mar Viloria Peñas, María</creatorcontrib><creatorcontrib>Simón Pilo, Isabel</creatorcontrib><creatorcontrib>Almeida González, Carmen</creatorcontrib><title>The influence of the age in the risk of the prothrombin G20210A mutation for spontaneous venous thrombosis</title><title>Medicina clínica</title><addtitle>Med Clin (Barc)</addtitle><description>Factor V Leiden mutation (FVL), and the prothrombin G20210A mutation (PT G20210A) are polymorphisms with a weak risk factor for venous thromboembolic disease. The probability of spontaneous venous thrombosis in carriers of thrombophilic mutations (FVL and PT G20210A) was analyzed.
We studied 735 individuals (407 were healthy controls and 328 patients with venous thrombosis) with respect to FVL and PT G20210A, determined by polimerase chain reaction in liquid phase, real time. χ
2 test and logistic regression analysis were used to evaluate the results. The dates were analyzed with the statistical program SPSS v. 14.0.
The carrier patients of PT G20210A mutation whose age was over 40 years had a risk factor for spontaneous venous thrombosis which was 9.28 (odds ratio [OR]) (95% confidence interval [CI], 3.01-28.60; p
<
0.0005) times greater than carriers of the PT G20210A mutation who were 40 year-old or younger. In our patients, being male meant a weak risk factor for venous spontaneous thrombosis (p
=
0.021; OR
=
1.64; 95% CI, 1.08-2.51).
Our results demonstrate a potentiation of the thrombotic risk by an increase of age in the carriers of the PT G20210A mutation.
El factor V Leiden (FVL) y la mutación de la protrombina G20210A (PT G20210A) son unos polimorfismos que suponen un débil factor de riesgo para presentar enfermedad tromboembólica venosa. Hemos analizado la probabilidad de tener una trombosis venosa espontánea en los portadores de las mutaciones trombofílicas (FVL y PT G20210A).
Hemos estudiado a 735 personas (407 controles sanos y 328 pacientes con trombosis venosa) con relación al FVL y a la PT G20210A, determinados por reacción en cadena de la polimerasa en fase líquida, en tiempo real. Para evaluar los resultados utilizamos el test de la χ
2 y el análisis de regresión logística. Los datos se analizaron con el programa estadístico SPSS versión 14.0.
Los pacientes con la mutación PT G20210A que eran mayores de 40 años tuvieron un factor de riesgo para trombosis venosa espontánea con una
odds ratio (OR) 9,28 (intervalo de confianza (IC) del 95%, 3,01- 28,60; p
<
0,0005) veces mayor que los portadores de la mutación PT G20210A que tenían 40 años o menos. En nuestra serie el sexo masculino representó un factor de riesgo débil para trombosis venosa espontánea (p
=
0,021; OR
=
1,64; IC del 95%, 1,08-2,51).
Nuestros resultados demuestran una potenciación del riesgo trombótico por el incremento de la edad en los individuos portadores de la mutación PT G20210A.</description><subject>Age Factors</subject><subject>Case-Control Studies</subject><subject>Enfermedad tromoboembólica</subject><subject>Factor de riesgo</subject><subject>Factor V Leiden</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Prospective Studies</subject><subject>Prothrombin - genetics</subject><subject>Prothrombin G20210A</subject><subject>Protrombina G20210A</subject><subject>Risk factor</subject><subject>Risk Factors</subject><subject>Thromboembolism disease</subject><subject>Venous Thrombosis - genetics</subject><issn>0025-7753</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkDFPwzAQhT2AaClI_AKUCbEEfHacNGNVQUGqxFJmy3Fs6pLExXYq8e9xSCsGpju_-_x09xC6AfwAwIpHoIAJZnCGphgTlhYFoxN06f1ueFIoLtAEolbQnEzRbrNViel006tOqsTqJERBfAzib-uM_zzJe2fD1tm2irMVwQTwImn7IIKxXaKtS_zedkF0yvY-OahuKOMH642_QudaNF5dH-sMvT8_bZYv6fpt9bpcrFNJ5iyktCIsz5gWuNJzqmhZyEyXmrASNNAyZ1WZMVqLuagJrQGgVJDV1ZxmlYwcpTN0N_rGdb965QNvjZeqacbFeIFZXpSQRfB-BKWz3jul-d6ZVrhvDpgPWfJTlhG9PXr2VavqP_AYZATICKh42cEox700Q6S1cUoGXlvz3_UHet2AaA</recordid><startdate>20070505</startdate><enddate>20070505</enddate><creator>Reyes Gutiérrez Tous, María</creator><creator>Couto Caro, Carmen</creator><creator>García-Donas Gabaldón, Gloria</creator><creator>del Mar Viloria Peñas, María</creator><creator>Simón Pilo, Isabel</creator><creator>Almeida González, Carmen</creator><general>Elsevier Espana</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070505</creationdate><title>The influence of the age in the risk of the prothrombin G20210A mutation for spontaneous venous thrombosis</title><author>Reyes Gutiérrez Tous, María ; Couto Caro, Carmen ; García-Donas Gabaldón, Gloria ; del Mar Viloria Peñas, María ; Simón Pilo, Isabel ; Almeida González, Carmen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c285t-3b25645fa0bf83e397c4f9f2591f13965b9453da8ad23d1119e14db834bcf9f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Age Factors</topic><topic>Case-Control Studies</topic><topic>Enfermedad tromoboembólica</topic><topic>Factor de riesgo</topic><topic>Factor V Leiden</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Prospective Studies</topic><topic>Prothrombin - genetics</topic><topic>Prothrombin G20210A</topic><topic>Protrombina G20210A</topic><topic>Risk factor</topic><topic>Risk Factors</topic><topic>Thromboembolism disease</topic><topic>Venous Thrombosis - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reyes Gutiérrez Tous, María</creatorcontrib><creatorcontrib>Couto Caro, Carmen</creatorcontrib><creatorcontrib>García-Donas Gabaldón, Gloria</creatorcontrib><creatorcontrib>del Mar Viloria Peñas, María</creatorcontrib><creatorcontrib>Simón Pilo, Isabel</creatorcontrib><creatorcontrib>Almeida González, Carmen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medicina clínica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reyes Gutiérrez Tous, María</au><au>Couto Caro, Carmen</au><au>García-Donas Gabaldón, Gloria</au><au>del Mar Viloria Peñas, María</au><au>Simón Pilo, Isabel</au><au>Almeida González, Carmen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of the age in the risk of the prothrombin G20210A mutation for spontaneous venous thrombosis</atitle><jtitle>Medicina clínica</jtitle><addtitle>Med Clin (Barc)</addtitle><date>2007-05-05</date><risdate>2007</risdate><volume>128</volume><issue>17</issue><spage>652</spage><epage>654</epage><pages>652-654</pages><issn>0025-7753</issn><abstract>Factor V Leiden mutation (FVL), and the prothrombin G20210A mutation (PT G20210A) are polymorphisms with a weak risk factor for venous thromboembolic disease. The probability of spontaneous venous thrombosis in carriers of thrombophilic mutations (FVL and PT G20210A) was analyzed.
We studied 735 individuals (407 were healthy controls and 328 patients with venous thrombosis) with respect to FVL and PT G20210A, determined by polimerase chain reaction in liquid phase, real time. χ
2 test and logistic regression analysis were used to evaluate the results. The dates were analyzed with the statistical program SPSS v. 14.0.
The carrier patients of PT G20210A mutation whose age was over 40 years had a risk factor for spontaneous venous thrombosis which was 9.28 (odds ratio [OR]) (95% confidence interval [CI], 3.01-28.60; p
<
0.0005) times greater than carriers of the PT G20210A mutation who were 40 year-old or younger. In our patients, being male meant a weak risk factor for venous spontaneous thrombosis (p
=
0.021; OR
=
1.64; 95% CI, 1.08-2.51).
Our results demonstrate a potentiation of the thrombotic risk by an increase of age in the carriers of the PT G20210A mutation.
El factor V Leiden (FVL) y la mutación de la protrombina G20210A (PT G20210A) son unos polimorfismos que suponen un débil factor de riesgo para presentar enfermedad tromboembólica venosa. Hemos analizado la probabilidad de tener una trombosis venosa espontánea en los portadores de las mutaciones trombofílicas (FVL y PT G20210A).
Hemos estudiado a 735 personas (407 controles sanos y 328 pacientes con trombosis venosa) con relación al FVL y a la PT G20210A, determinados por reacción en cadena de la polimerasa en fase líquida, en tiempo real. Para evaluar los resultados utilizamos el test de la χ
2 y el análisis de regresión logística. Los datos se analizaron con el programa estadístico SPSS versión 14.0.
Los pacientes con la mutación PT G20210A que eran mayores de 40 años tuvieron un factor de riesgo para trombosis venosa espontánea con una
odds ratio (OR) 9,28 (intervalo de confianza (IC) del 95%, 3,01- 28,60; p
<
0,0005) veces mayor que los portadores de la mutación PT G20210A que tenían 40 años o menos. En nuestra serie el sexo masculino representó un factor de riesgo débil para trombosis venosa espontánea (p
=
0,021; OR
=
1,64; IC del 95%, 1,08-2,51).
Nuestros resultados demuestran una potenciación del riesgo trombótico por el incremento de la edad en los individuos portadores de la mutación PT G20210A.</abstract><cop>Spain</cop><pub>Elsevier Espana</pub><pmid>17537362</pmid><doi>10.1157/13102051</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Medicina clínica, 2007-05, Vol.128 (17), p.652-654 |
| issn | 0025-7753 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70567914 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Age Factors Case-Control Studies Enfermedad tromoboembólica Factor de riesgo Factor V Leiden Female Humans Male Middle Aged Mutation Prospective Studies Prothrombin - genetics Prothrombin G20210A Protrombina G20210A Risk factor Risk Factors Thromboembolism disease Venous Thrombosis - genetics |
| title | The influence of the age in the risk of the prothrombin G20210A mutation for spontaneous venous thrombosis |
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