The role of the endothelin axis and microvessel density in bladder cancer - : correlation with tumor angiogenesis and clinical prognosis
Endothelin-1 (ET-1) and its receptors, entothelin-A (ETAR) and endothelin-B (ETBR), commonly referred to as the endothelin (ET)-axis, are involved in tumor biology and growth. We investigated the effects of the ET-axis on microvessel density (MVD) and the clinicopathological parameters of patients w...
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Veröffentlicht in: | Oncology reports 2007-07, Vol.18 (1), p.133-138 |
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description | Endothelin-1 (ET-1) and its receptors, entothelin-A (ETAR) and endothelin-B (ETBR), commonly referred to as the endothelin (ET)-axis, are involved in tumor biology and growth. We investigated the effects of the ET-axis on microvessel density (MVD) and the clinicopathological parameters of patients with invasive bladder cancer. Paraffin tumor sections of 120 patients who had undergone radical cystectomy were assessed immunohistochemically using mono- and polyclonal antibodies for ET-1, ETAR, ETBR and CD34 (MVD). Staining intensities were analyzed semiquantitatively and the MVD was calculated as vessels per field. The results were correlated with various pathological and clinical factors, as well as with disease-free and overall survival. Transitional cell carcinomas (MVD=23.7) were better vascularized than squamous cell carcinomas (MVD=17.8, p=0.04). Organ-confined tumors (MVD=32.2) were better vascularized than T3- and T4-tumors (MVD=21.2, p=0.02) and ET-1 was overexpressed in this subgroup (p=0.027). Patients with metastatic regional lymph nodes (MVD=20.9) tended to have less MVD than patients without regional lymph node metastases (MVD=24.1) (p=0.15). The account of MVD did not reveal any significant differences in disease-free or overall survival. Organ-confined tumors and ET-1 overexpression are associated with upregulated microvessel density. These results suggest that MVD and ET-1 could be considered good prognostic factors. |
doi_str_mv | 10.3892/or.18.1.133 |
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We investigated the effects of the ET-axis on microvessel density (MVD) and the clinicopathological parameters of patients with invasive bladder cancer. Paraffin tumor sections of 120 patients who had undergone radical cystectomy were assessed immunohistochemically using mono- and polyclonal antibodies for ET-1, ETAR, ETBR and CD34 (MVD). Staining intensities were analyzed semiquantitatively and the MVD was calculated as vessels per field. The results were correlated with various pathological and clinical factors, as well as with disease-free and overall survival. Transitional cell carcinomas (MVD=23.7) were better vascularized than squamous cell carcinomas (MVD=17.8, p=0.04). Organ-confined tumors (MVD=32.2) were better vascularized than T3- and T4-tumors (MVD=21.2, p=0.02) and ET-1 was overexpressed in this subgroup (p=0.027). Patients with metastatic regional lymph nodes (MVD=20.9) tended to have less MVD than patients without regional lymph node metastases (MVD=24.1) (p=0.15). The account of MVD did not reveal any significant differences in disease-free or overall survival. Organ-confined tumors and ET-1 overexpression are associated with upregulated microvessel density. These results suggest that MVD and ET-1 could be considered good prognostic factors.</description><identifier>ISSN: 1021-335X</identifier><identifier>EISSN: 1791-2431</identifier><identifier>DOI: 10.3892/or.18.1.133</identifier><identifier>PMID: 17549358</identifier><language>eng</language><publisher>Athens: S.n.</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Carcinoma, Squamous Cell - blood supply ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - secondary ; Carcinoma, Transitional Cell - blood supply ; Carcinoma, Transitional Cell - metabolism ; Carcinoma, Transitional Cell - secondary ; Cystectomy ; Endothelin-1 - metabolism ; Female ; Humans ; Immunoenzyme Techniques ; Lymph Nodes - metabolism ; Lymph Nodes - pathology ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Neovascularization, Pathologic - pathology ; Nephrology. Urinary tract diseases ; Prognosis ; Receptor, Endothelin A - metabolism ; Receptor, Endothelin B - metabolism ; Survival Rate ; Tumors ; Tumors of the urinary system ; Urinary Bladder Neoplasms - blood supply ; Urinary Bladder Neoplasms - metabolism ; Urinary tract. 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We investigated the effects of the ET-axis on microvessel density (MVD) and the clinicopathological parameters of patients with invasive bladder cancer. Paraffin tumor sections of 120 patients who had undergone radical cystectomy were assessed immunohistochemically using mono- and polyclonal antibodies for ET-1, ETAR, ETBR and CD34 (MVD). Staining intensities were analyzed semiquantitatively and the MVD was calculated as vessels per field. The results were correlated with various pathological and clinical factors, as well as with disease-free and overall survival. Transitional cell carcinomas (MVD=23.7) were better vascularized than squamous cell carcinomas (MVD=17.8, p=0.04). Organ-confined tumors (MVD=32.2) were better vascularized than T3- and T4-tumors (MVD=21.2, p=0.02) and ET-1 was overexpressed in this subgroup (p=0.027). Patients with metastatic regional lymph nodes (MVD=20.9) tended to have less MVD than patients without regional lymph node metastases (MVD=24.1) (p=0.15). The account of MVD did not reveal any significant differences in disease-free or overall survival. Organ-confined tumors and ET-1 overexpression are associated with upregulated microvessel density. These results suggest that MVD and ET-1 could be considered good prognostic factors.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Squamous Cell - blood supply</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Carcinoma, Transitional Cell - blood supply</subject><subject>Carcinoma, Transitional Cell - metabolism</subject><subject>Carcinoma, Transitional Cell - secondary</subject><subject>Cystectomy</subject><subject>Endothelin-1 - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Lymph Nodes - metabolism</subject><subject>Lymph Nodes - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Prognosis</subject><subject>Receptor, Endothelin A - metabolism</subject><subject>Receptor, Endothelin B - metabolism</subject><subject>Survival Rate</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary Bladder Neoplasms - blood supply</subject><subject>Urinary Bladder Neoplasms - metabolism</subject><subject>Urinary tract. 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Urinary tract diseases</topic><topic>Prognosis</topic><topic>Receptor, Endothelin A - metabolism</topic><topic>Receptor, Endothelin B - metabolism</topic><topic>Survival Rate</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary Bladder Neoplasms - blood supply</topic><topic>Urinary Bladder Neoplasms - metabolism</topic><topic>Urinary tract. Prostate gland</topic><toplevel>online_resources</toplevel><creatorcontrib>HERRMANN, Edwin</creatorcontrib><creatorcontrib>BÖGEMANN, Martin</creatorcontrib><creatorcontrib>BIERER, Stefan</creatorcontrib><creatorcontrib>ELTZE, Elke</creatorcontrib><creatorcontrib>TOMA, Marieta I</creatorcontrib><creatorcontrib>KÖPKE, Thomas</creatorcontrib><creatorcontrib>HERTLE, Lothar</creatorcontrib><creatorcontrib>WÜLFING, Christian</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oncology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HERRMANN, Edwin</au><au>BÖGEMANN, Martin</au><au>BIERER, Stefan</au><au>ELTZE, Elke</au><au>TOMA, Marieta I</au><au>KÖPKE, Thomas</au><au>HERTLE, Lothar</au><au>WÜLFING, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of the endothelin axis and microvessel density in bladder cancer - : correlation with tumor angiogenesis and clinical prognosis</atitle><jtitle>Oncology reports</jtitle><addtitle>Oncol Rep</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>18</volume><issue>1</issue><spage>133</spage><epage>138</epage><pages>133-138</pages><issn>1021-335X</issn><eissn>1791-2431</eissn><abstract>Endothelin-1 (ET-1) and its receptors, entothelin-A (ETAR) and endothelin-B (ETBR), commonly referred to as the endothelin (ET)-axis, are involved in tumor biology and growth. We investigated the effects of the ET-axis on microvessel density (MVD) and the clinicopathological parameters of patients with invasive bladder cancer. Paraffin tumor sections of 120 patients who had undergone radical cystectomy were assessed immunohistochemically using mono- and polyclonal antibodies for ET-1, ETAR, ETBR and CD34 (MVD). Staining intensities were analyzed semiquantitatively and the MVD was calculated as vessels per field. The results were correlated with various pathological and clinical factors, as well as with disease-free and overall survival. Transitional cell carcinomas (MVD=23.7) were better vascularized than squamous cell carcinomas (MVD=17.8, p=0.04). Organ-confined tumors (MVD=32.2) were better vascularized than T3- and T4-tumors (MVD=21.2, p=0.02) and ET-1 was overexpressed in this subgroup (p=0.027). Patients with metastatic regional lymph nodes (MVD=20.9) tended to have less MVD than patients without regional lymph node metastases (MVD=24.1) (p=0.15). The account of MVD did not reveal any significant differences in disease-free or overall survival. Organ-confined tumors and ET-1 overexpression are associated with upregulated microvessel density. These results suggest that MVD and ET-1 could be considered good prognostic factors.</abstract><cop>Athens</cop><pub>S.n.</pub><pmid>17549358</pmid><doi>10.3892/or.18.1.133</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoma, Squamous Cell - blood supply Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - secondary Carcinoma, Transitional Cell - blood supply Carcinoma, Transitional Cell - metabolism Carcinoma, Transitional Cell - secondary Cystectomy Endothelin-1 - metabolism Female Humans Immunoenzyme Techniques Lymph Nodes - metabolism Lymph Nodes - pathology Male Medical sciences Middle Aged Neoplasm Staging Neovascularization, Pathologic - pathology Nephrology. Urinary tract diseases Prognosis Receptor, Endothelin A - metabolism Receptor, Endothelin B - metabolism Survival Rate Tumors Tumors of the urinary system Urinary Bladder Neoplasms - blood supply Urinary Bladder Neoplasms - metabolism Urinary tract. Prostate gland |
title | The role of the endothelin axis and microvessel density in bladder cancer - : correlation with tumor angiogenesis and clinical prognosis |
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