Differential neuroimmune markers to the onset of Alzheimer's disease neurodegeneration and dementia: autoantibodies to Abeta((25-35)) oligomers, S100b and neurotransmitters
Alzheimer's disease (AD) autoimmunity is a focus for dementia prevention. Generated autoantibodies against major etiopathogenic molecular targets as neuroimmune markers of dementia were measured by ELISA in patient sera. Biphasic antibody levels to Abeta((25-35)) oligomers, S100b and DA were de...
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| Veröffentlicht in: | Journal of neuroimmunology 2007-05, Vol.186 (1-2), p.181-192 |
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| container_title | Journal of neuroimmunology |
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| creator | Gruden, Marina A Davidova, Tatyana B Malisauskas, Mantas Sewell, Robert D E Voskresenskaya, Nina I Wilhelm, Kristina Elistratova, Elena I Sherstnev, Vladimir V Morozova-Roche, Ludmilla A |
| description | Alzheimer's disease (AD) autoimmunity is a focus for dementia prevention. Generated autoantibodies against major etiopathogenic molecular targets as neuroimmune markers of dementia were measured by ELISA in patient sera. Biphasic antibody levels to Abeta((25-35)) oligomers, S100b and DA were detected during distinctly diagnosed dementia stages. Abeta((25-35)) oligomer autoimmune responses reflected mild to moderate AD dementia, while those to S100b, DA and the S100b concentrations, matched moderate to severe dementia progression. 5-HT antibodies increased during mild dementia and plateaued thereafter. This autoimmunity pattern may be used as a differential biomarker profile in designing AD therapeutic strategies involving early vaccination. |
| format | Article |
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Generated autoantibodies against major etiopathogenic molecular targets as neuroimmune markers of dementia were measured by ELISA in patient sera. Biphasic antibody levels to Abeta((25-35)) oligomers, S100b and DA were detected during distinctly diagnosed dementia stages. Abeta((25-35)) oligomer autoimmune responses reflected mild to moderate AD dementia, while those to S100b, DA and the S100b concentrations, matched moderate to severe dementia progression. 5-HT antibodies increased during mild dementia and plateaued thereafter. This autoimmunity pattern may be used as a differential biomarker profile in designing AD therapeutic strategies involving early vaccination.</description><identifier>ISSN: 0165-5728</identifier><identifier>PMID: 17477976</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - complications ; Alzheimer Disease - immunology ; Alzheimer Disease - metabolism ; Alzheimer Disease - pathology ; Amyloid beta-Peptides - immunology ; Antibodies - metabolism ; Cognition Disorders - etiology ; Dopamine ; Enzyme-Linked Immunosorbent Assay - methods ; Female ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging - methods ; Nerve Degeneration - immunology ; Nerve Degeneration - metabolism ; Nerve Degeneration - pathology ; Nerve Growth Factors - immunology ; Peptide Fragments - immunology ; Peptide Fragments - metabolism ; S100 Calcium Binding Protein beta Subunit ; S100 Proteins - immunology ; Serotonin - metabolism</subject><ispartof>Journal of neuroimmunology, 2007-05, Vol.186 (1-2), p.181-192</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17477976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gruden, Marina A</creatorcontrib><creatorcontrib>Davidova, Tatyana B</creatorcontrib><creatorcontrib>Malisauskas, Mantas</creatorcontrib><creatorcontrib>Sewell, Robert D E</creatorcontrib><creatorcontrib>Voskresenskaya, Nina I</creatorcontrib><creatorcontrib>Wilhelm, Kristina</creatorcontrib><creatorcontrib>Elistratova, Elena I</creatorcontrib><creatorcontrib>Sherstnev, Vladimir V</creatorcontrib><creatorcontrib>Morozova-Roche, Ludmilla A</creatorcontrib><title>Differential neuroimmune markers to the onset of Alzheimer's disease neurodegeneration and dementia: autoantibodies to Abeta((25-35)) oligomers, S100b and neurotransmitters</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Alzheimer's disease (AD) autoimmunity is a focus for dementia prevention. Generated autoantibodies against major etiopathogenic molecular targets as neuroimmune markers of dementia were measured by ELISA in patient sera. Biphasic antibody levels to Abeta((25-35)) oligomers, S100b and DA were detected during distinctly diagnosed dementia stages. Abeta((25-35)) oligomer autoimmune responses reflected mild to moderate AD dementia, while those to S100b, DA and the S100b concentrations, matched moderate to severe dementia progression. 5-HT antibodies increased during mild dementia and plateaued thereafter. This autoimmunity pattern may be used as a differential biomarker profile in designing AD therapeutic strategies involving early vaccination.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - complications</subject><subject>Alzheimer Disease - immunology</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - pathology</subject><subject>Amyloid beta-Peptides - immunology</subject><subject>Antibodies - metabolism</subject><subject>Cognition Disorders - etiology</subject><subject>Dopamine</subject><subject>Enzyme-Linked Immunosorbent Assay - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Nerve Degeneration - immunology</subject><subject>Nerve Degeneration - metabolism</subject><subject>Nerve Degeneration - pathology</subject><subject>Nerve Growth Factors - immunology</subject><subject>Peptide Fragments - immunology</subject><subject>Peptide Fragments - metabolism</subject><subject>S100 Calcium Binding Protein beta Subunit</subject><subject>S100 Proteins - immunology</subject><subject>Serotonin - metabolism</subject><issn>0165-5728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kL1OwzAUhTOAaCm8AvIEVCKSk_inYavKr1SJge6RHV-3htgutjPAM_GQRGmZ7pHu-b7hnGRTXDCaU14uJtl5jB8YF7Qi9Vk2KTjhvOZsmv0-GK0hgEtGdMhBH7yxtneArAifECJKHqUdIO8iJOQ1WnY_OzAWwk1EykQQEQ6cgi04CCIZ75BwCimwo_ceiT55MUTplYFRuZSQxO1tSfOKzufId2brB2e8Q-8FxnLkR2sKwkVrUhqeF9mpFl2Ey-OdZZunx83qJV-_Pb-ulut8TwnLaypJpXSrJdZ1S6AlFQWQTFHKJNG4XAAvWwmcUGBMcYxpDZozXkheiwJXs-z6oN0H_9VDTI01sYWuEw58HxuOKWMDNhSvjsVeWlDNPphhte_mf97qD00veNM</recordid><startdate>200705</startdate><enddate>200705</enddate><creator>Gruden, Marina A</creator><creator>Davidova, Tatyana B</creator><creator>Malisauskas, Mantas</creator><creator>Sewell, Robert D E</creator><creator>Voskresenskaya, Nina I</creator><creator>Wilhelm, Kristina</creator><creator>Elistratova, Elena I</creator><creator>Sherstnev, Vladimir V</creator><creator>Morozova-Roche, Ludmilla A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200705</creationdate><title>Differential neuroimmune markers to the onset of Alzheimer's disease neurodegeneration and dementia: autoantibodies to Abeta((25-35)) oligomers, S100b and neurotransmitters</title><author>Gruden, Marina A ; Davidova, Tatyana B ; Malisauskas, Mantas ; Sewell, Robert D E ; Voskresenskaya, Nina I ; Wilhelm, Kristina ; Elistratova, Elena I ; Sherstnev, Vladimir V ; Morozova-Roche, Ludmilla A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p546-95b43dfcfb0f9c4ec435eeb6d556b4f028e72cbe745e66d70059ef7671b79a103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - complications</topic><topic>Alzheimer Disease - immunology</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - pathology</topic><topic>Amyloid beta-Peptides - immunology</topic><topic>Antibodies - metabolism</topic><topic>Cognition Disorders - etiology</topic><topic>Dopamine</topic><topic>Enzyme-Linked Immunosorbent Assay - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Nerve Degeneration - immunology</topic><topic>Nerve Degeneration - metabolism</topic><topic>Nerve Degeneration - pathology</topic><topic>Nerve Growth Factors - immunology</topic><topic>Peptide Fragments - immunology</topic><topic>Peptide Fragments - metabolism</topic><topic>S100 Calcium Binding Protein beta Subunit</topic><topic>S100 Proteins - immunology</topic><topic>Serotonin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gruden, Marina A</creatorcontrib><creatorcontrib>Davidova, Tatyana B</creatorcontrib><creatorcontrib>Malisauskas, Mantas</creatorcontrib><creatorcontrib>Sewell, Robert D E</creatorcontrib><creatorcontrib>Voskresenskaya, Nina I</creatorcontrib><creatorcontrib>Wilhelm, Kristina</creatorcontrib><creatorcontrib>Elistratova, Elena I</creatorcontrib><creatorcontrib>Sherstnev, Vladimir V</creatorcontrib><creatorcontrib>Morozova-Roche, Ludmilla A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gruden, Marina A</au><au>Davidova, Tatyana B</au><au>Malisauskas, Mantas</au><au>Sewell, Robert D E</au><au>Voskresenskaya, Nina I</au><au>Wilhelm, Kristina</au><au>Elistratova, Elena I</au><au>Sherstnev, Vladimir V</au><au>Morozova-Roche, Ludmilla A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential neuroimmune markers to the onset of Alzheimer's disease neurodegeneration and dementia: autoantibodies to Abeta((25-35)) oligomers, S100b and neurotransmitters</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2007-05</date><risdate>2007</risdate><volume>186</volume><issue>1-2</issue><spage>181</spage><epage>192</epage><pages>181-192</pages><issn>0165-5728</issn><abstract>Alzheimer's disease (AD) autoimmunity is a focus for dementia prevention. Generated autoantibodies against major etiopathogenic molecular targets as neuroimmune markers of dementia were measured by ELISA in patient sera. Biphasic antibody levels to Abeta((25-35)) oligomers, S100b and DA were detected during distinctly diagnosed dementia stages. Abeta((25-35)) oligomer autoimmune responses reflected mild to moderate AD dementia, while those to S100b, DA and the S100b concentrations, matched moderate to severe dementia progression. 5-HT antibodies increased during mild dementia and plateaued thereafter. This autoimmunity pattern may be used as a differential biomarker profile in designing AD therapeutic strategies involving early vaccination.</abstract><cop>Netherlands</cop><pmid>17477976</pmid><tpages>12</tpages></addata></record> |
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| ispartof | Journal of neuroimmunology, 2007-05, Vol.186 (1-2), p.181-192 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aged Aged, 80 and over Alzheimer Disease - complications Alzheimer Disease - immunology Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid beta-Peptides - immunology Antibodies - metabolism Cognition Disorders - etiology Dopamine Enzyme-Linked Immunosorbent Assay - methods Female Humans Longitudinal Studies Magnetic Resonance Imaging - methods Nerve Degeneration - immunology Nerve Degeneration - metabolism Nerve Degeneration - pathology Nerve Growth Factors - immunology Peptide Fragments - immunology Peptide Fragments - metabolism S100 Calcium Binding Protein beta Subunit S100 Proteins - immunology Serotonin - metabolism |
| title | Differential neuroimmune markers to the onset of Alzheimer's disease neurodegeneration and dementia: autoantibodies to Abeta((25-35)) oligomers, S100b and neurotransmitters |
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