Ovarian Tumor Cells Express a Transmembrane Serine Protease: A Potential Candidate for Early Diagnosis and Therapeutic Intervention

Proteases have been implicated in the extracellular modulation required for tumor growth and invasion. In an effort to categorize those proteases contributing to ovarian carcinoma progression, we have utilized redundant primers to conserved amino acid (AA) domains surrounding the catalytic triad of...

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Veröffentlicht in:	Tumor biology 2001-03, Vol.22 (2), p.104-114
Hauptverfasser:	Tanimoto, Hirotoshi, Underwood, Lowell J., Wang, Yinxiang, Shigemasa, Kazushi, Parmley, Tim H., O’Brien, Timothy J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Aspartic Acid - chemistry Base Sequence Biological and medical sciences Blotting, Northern Blotting, Western Catalytic Domain Cell Line Cell Membrane - metabolism Cloning, Molecular DNA Primers - metabolism DNA, Complementary - metabolism Female Female genital diseases Gynecology. Andrology. Obstetrics Histidine - chemistry Humans Immunohistochemistry Ligands Medical sciences Mice Models, Biological Molecular Sequence Data Ovarian Neoplasms - diagnosis Ovarian Neoplasms - enzymology Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Ovary - metabolism Ovary - pathology Polymerase Chain Reaction Protein Binding Protein Structure, Tertiary Research Article Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Sequence Homology, Amino Acid Serine - chemistry Serine Endopeptidases - biosynthesis Tissue Distribution Tumor Cells, Cultured Tumors
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