Discovery of new C3aR ligands. Part 2: Amino-piperidine derivatives
The synthesis and structure–activity relationships against the C3a receptor of a series of substituted aminopiperidine derivatives are reported. DMPK properties and functional activities of selected compounds are described. The compounds obtained are the first non-arginine ligands of C3aR.
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2007-06, Vol.17 (12), p.3262-3265 |
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| container_end_page | 3265 |
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| container_issue | 12 |
| container_start_page | 3262 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 17 |
| creator | Denonne, Frédéric Binet, Sophie Burton, Maggi Collart, Philippe Defays, Sabine Dipesa, Alan Eckert, Maria Giannaras, Alexander Kumar, Seema Levine, Beth Nicolas, Jean-Marie Pasau, Patrick Pégurier, Cécile Preda, Dorin Van houtvin, Nathalie Volosov, Andrew Zou, Dong |
| description | The synthesis and structure–activity relationships against the C3a receptor of a series of substituted aminopiperidine derivatives are reported. DMPK properties and functional activities of selected compounds are described. The compounds obtained are the first non-arginine ligands of C3aR. |
| doi_str_mv | 10.1016/j.bmcl.2007.04.023 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2007-06, Vol.17 (12), p.3262-3265 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Agonist Amines - chemistry Animals Biological and medical sciences C3a Complement Activation - drug effects Inflammation Ligands Medical sciences Membrane Proteins - metabolism Mice Mice, Inbred BALB C Pharmacology. Drug treatments Piperidines - chemical synthesis Piperidines - pharmacology Protein Binding Protein-Serine-Threonine Kinases - metabolism Receptors, Complement - metabolism Respiratory system SAR Structure-Activity Relationship |
| title | Discovery of new C3aR ligands. Part 2: Amino-piperidine derivatives |
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