New oxypregnane glycosides from appetite suppressant herbal supplement Hoodia gordonii
Hoodigosides A–K ( 1– 11), eleven new oxypregnane glycosides and a previously reported oxypregnane glycoside P57AS3 were isolated from the aerial parts of Hoodia gordonii. The structures of these 12- O-β-tigloyl isoramanone glycosides were determined on the basis of chemical evidence and extensive s...
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| Veröffentlicht in: | Steroids 2007-06, Vol.72 (6), p.524-534 |
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| creator | Pawar, Rahul S. Shukla, Yatin J. Khan, Shabana I. Avula, Bharathi Khan, Ikhlas A. |
| description | Hoodigosides A–K (
1–
11), eleven new oxypregnane glycosides and a previously reported oxypregnane glycoside P57AS3 were isolated from the aerial parts of
Hoodia gordonii. The structures of these 12-
O-β-tigloyl isoramanone glycosides were determined on the basis of chemical evidence and extensive spectroscopic methods that include one-dimensional and two-dimensional NMR. Cytotoxicity and antioxidant activities of these compounds were tested in cell based assays where they were found to be inactive. |
| doi_str_mv | 10.1016/j.steroids.2007.03.003 |
| format | Article |
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1–
11), eleven new oxypregnane glycosides and a previously reported oxypregnane glycoside P57AS3 were isolated from the aerial parts of
Hoodia gordonii. The structures of these 12-
O-β-tigloyl isoramanone glycosides were determined on the basis of chemical evidence and extensive spectroscopic methods that include one-dimensional and two-dimensional NMR. Cytotoxicity and antioxidant activities of these compounds were tested in cell based assays where they were found to be inactive.</description><identifier>ISSN: 0039-128X</identifier><identifier>EISSN: 1878-5867</identifier><identifier>DOI: 10.1016/j.steroids.2007.03.003</identifier><identifier>PMID: 17467018</identifier><identifier>CODEN: STEDAM</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Antioxidants - pharmacology ; Apocynaceae - chemistry ; Appetite Depressants ; Asclepiadaceae ; Biological and medical sciences ; Carbohydrate Sequence ; Fundamental and applied biological sciences. Psychology ; Glycosides - isolation & purification ; Glycosides - pharmacology ; Hoodia gordonii ; Hoodigosides A–K ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Sequence Data ; Oxypregnane ; P57AS3 ; Spectrometry, Mass, Electrospray Ionization ; Vertebrates: endocrinology</subject><ispartof>Steroids, 2007-06, Vol.72 (6), p.524-534</ispartof><rights>2007 Elsevier Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-4464777ffcdbe230e3175532b3a37c761d0ba661a8929316926b6f9fd000b8953</citedby><cites>FETCH-LOGICAL-c396t-4464777ffcdbe230e3175532b3a37c761d0ba661a8929316926b6f9fd000b8953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0039128X07000475$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18825037$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17467018$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pawar, Rahul S.</creatorcontrib><creatorcontrib>Shukla, Yatin J.</creatorcontrib><creatorcontrib>Khan, Shabana I.</creatorcontrib><creatorcontrib>Avula, Bharathi</creatorcontrib><creatorcontrib>Khan, Ikhlas A.</creatorcontrib><title>New oxypregnane glycosides from appetite suppressant herbal supplement Hoodia gordonii</title><title>Steroids</title><addtitle>Steroids</addtitle><description>Hoodigosides A–K (
1–
11), eleven new oxypregnane glycosides and a previously reported oxypregnane glycoside P57AS3 were isolated from the aerial parts of
Hoodia gordonii. The structures of these 12-
O-β-tigloyl isoramanone glycosides were determined on the basis of chemical evidence and extensive spectroscopic methods that include one-dimensional and two-dimensional NMR. Cytotoxicity and antioxidant activities of these compounds were tested in cell based assays where they were found to be inactive.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antioxidants - pharmacology</subject><subject>Apocynaceae - chemistry</subject><subject>Appetite Depressants</subject><subject>Asclepiadaceae</subject><subject>Biological and medical sciences</subject><subject>Carbohydrate Sequence</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycosides - isolation & purification</subject><subject>Glycosides - pharmacology</subject><subject>Hoodia gordonii</subject><subject>Hoodigosides A–K</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Molecular Sequence Data</subject><subject>Oxypregnane</subject><subject>P57AS3</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><subject>Vertebrates: endocrinology</subject><issn>0039-128X</issn><issn>1878-5867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP3DAURq0KVKa0fwFlU3YJfiS2sytCFCqhsoGqO8uxb6YeJXHwzbSdf4_pDGLZ1ZU-nfs6hJwxWjHK5MWmwgVSDB4rTqmqqKgoFe_Iimmly0ZLdURWOWlLxvXPE_IBcUMplaLl78kJU7VUlOkV-fEd_hTx725OsJ7sBMV62LmIwQMWfYpjYecZlrBAgds5Q4h2WopfkDo7_IsGGCEntzH6YIt1TD5OIXwkx70dED4d6il5_Hr9cHVb3t3ffLu6vCudaOVS1rWslVJ973wHXFAQTDWN4J2wQjklmaedlZJZ3fJWMNly2cm-7X1-pdNtI07J-X7unOLTFnAxY0AHw5BfiVs0ijay1g3PoNyDLkXEBL2ZUxht2hlGzYtRszGvRs2LUUOFyf5y49lhw7Ybwb-1HRRm4PMBsOjs0Cc7uYBvnNa8oUJl7sueg-zjd4Bk0AWYHPiQwC3Gx_C_W54BEMWZEw</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Pawar, Rahul S.</creator><creator>Shukla, Yatin J.</creator><creator>Khan, Shabana I.</creator><creator>Avula, Bharathi</creator><creator>Khan, Ikhlas A.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070601</creationdate><title>New oxypregnane glycosides from appetite suppressant herbal supplement Hoodia gordonii</title><author>Pawar, Rahul S. ; Shukla, Yatin J. ; Khan, Shabana I. ; Avula, Bharathi ; Khan, Ikhlas A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-4464777ffcdbe230e3175532b3a37c761d0ba661a8929316926b6f9fd000b8953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antioxidants - pharmacology</topic><topic>Apocynaceae - chemistry</topic><topic>Appetite Depressants</topic><topic>Asclepiadaceae</topic><topic>Biological and medical sciences</topic><topic>Carbohydrate Sequence</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycosides - isolation & purification</topic><topic>Glycosides - pharmacology</topic><topic>Hoodia gordonii</topic><topic>Hoodigosides A–K</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Molecular Sequence Data</topic><topic>Oxypregnane</topic><topic>P57AS3</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pawar, Rahul S.</creatorcontrib><creatorcontrib>Shukla, Yatin J.</creatorcontrib><creatorcontrib>Khan, Shabana I.</creatorcontrib><creatorcontrib>Avula, Bharathi</creatorcontrib><creatorcontrib>Khan, Ikhlas A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Steroids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pawar, Rahul S.</au><au>Shukla, Yatin J.</au><au>Khan, Shabana I.</au><au>Avula, Bharathi</au><au>Khan, Ikhlas A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New oxypregnane glycosides from appetite suppressant herbal supplement Hoodia gordonii</atitle><jtitle>Steroids</jtitle><addtitle>Steroids</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>72</volume><issue>6</issue><spage>524</spage><epage>534</epage><pages>524-534</pages><issn>0039-128X</issn><eissn>1878-5867</eissn><coden>STEDAM</coden><abstract>Hoodigosides A–K (
1–
11), eleven new oxypregnane glycosides and a previously reported oxypregnane glycoside P57AS3 were isolated from the aerial parts of
Hoodia gordonii. The structures of these 12-
O-β-tigloyl isoramanone glycosides were determined on the basis of chemical evidence and extensive spectroscopic methods that include one-dimensional and two-dimensional NMR. Cytotoxicity and antioxidant activities of these compounds were tested in cell based assays where they were found to be inactive.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17467018</pmid><doi>10.1016/j.steroids.2007.03.003</doi><tpages>11</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antineoplastic Agents - pharmacology Antioxidants - pharmacology Apocynaceae - chemistry Appetite Depressants Asclepiadaceae Biological and medical sciences Carbohydrate Sequence Fundamental and applied biological sciences. Psychology Glycosides - isolation & purification Glycosides - pharmacology Hoodia gordonii Hoodigosides A–K Humans Magnetic Resonance Spectroscopy Molecular Sequence Data Oxypregnane P57AS3 Spectrometry, Mass, Electrospray Ionization Vertebrates: endocrinology |
| title | New oxypregnane glycosides from appetite suppressant herbal supplement Hoodia gordonii |
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