New oxypregnane glycosides from appetite suppressant herbal supplement Hoodia gordonii

Hoodigosides A–K ( 1– 11), eleven new oxypregnane glycosides and a previously reported oxypregnane glycoside P57AS3 were isolated from the aerial parts of Hoodia gordonii. The structures of these 12- O-β-tigloyl isoramanone glycosides were determined on the basis of chemical evidence and extensive s...

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Veröffentlicht in:Steroids 2007-06, Vol.72 (6), p.524-534
Hauptverfasser: Pawar, Rahul S., Shukla, Yatin J., Khan, Shabana I., Avula, Bharathi, Khan, Ikhlas A.
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Sprache:eng
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Zusammenfassung:Hoodigosides A–K ( 1– 11), eleven new oxypregnane glycosides and a previously reported oxypregnane glycoside P57AS3 were isolated from the aerial parts of Hoodia gordonii. The structures of these 12- O-β-tigloyl isoramanone glycosides were determined on the basis of chemical evidence and extensive spectroscopic methods that include one-dimensional and two-dimensional NMR. Cytotoxicity and antioxidant activities of these compounds were tested in cell based assays where they were found to be inactive.
ISSN:0039-128X
1878-5867
DOI:10.1016/j.steroids.2007.03.003