5‘-Deoxyadenosine Contacts the Substrate Radical Intermediate in the Active Site of Ethanolamine Ammonia-lyase:  2H and 13C Electron Nuclear Double Resonance Studies

The mechanism of propagation of the radical center between the cofactor, substrate, and product in the adenosylcobalamin- (AdoCbl) dependent reaction of ethanolamine ammonia-lyase has been probed by pulsed electron nuclear double resonance (ENDOR) spectroscopy. The radical of S-2-aminopropanol, whic...

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Veröffentlicht in:	Biochemistry (Easton) 2001-01, Vol.40 (1), p.9-14
Hauptverfasser:	LoBrutto, Russell, Bandarian, Vahe, Magnusson, Olafur Th, Chen, Xiangyang, Schramm, Vern L, Reed, George H
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Carbon Isotopes Cobamides - chemistry Deoxyadenosines - chemistry Deuterium Electron Spin Resonance Spectroscopy - methods Ethanolamine Ammonia-Lyase - chemistry Free Radicals - chemistry Propanolamines - chemistry Substrate Specificity
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