Lymphotoxin-alpha deficiency completely protects C57BL/6 mice from developing clinical experimental autoimmune myasthenia gravis

A complete prevention of clinical experimental autoimmune myasthenia gravis (EAMG) was observed in lymphotoxin (LT)-α deficient (LT-α −/−) mice compared to LT-α +/+ mice when immunized with acetylcholine receptor. However, only a partial prevention of clinical EAMG incidence was observed in LT-β −/−...

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Veröffentlicht in:	Journal of neuroimmunology 2001-02, Vol.113 (1), p.109-118
Hauptverfasser:	Goluszko, Elzbieta, Hjelmström, Peter, Deng, Caishu, Poussin, Mathilde A., Ruddle, Nancy H., Christadoss, Premkumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors Animals Antigens, CD - genetics Antigens, CD - immunology Autoantibodies - blood Autoimmunity B7-2 Antigen Cytokines experimental myasthenia gravis Gene Expression - immunology Immunodominant Epitopes - immunology Immunoglobulin G - blood Immunoglobulin M - blood lymphotoxin-^a Lymphotoxin-alpha - genetics Lymphotoxin-alpha - immunology Lymphotoxins Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Mice Mice, Inbred C57BL Mice, Knockout Myasthenia gravis Myasthenia Gravis, Autoimmune, Experimental - immunology Receptors, Cholinergic - immunology Receptors, Tumor Necrosis Factor - immunology Spleen - cytology Spleen - immunology TNF receptors
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