Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia

Abstract Aberrant glutamatergic neurotransmission may underlie the pathogenesis of schizophrenia and metabotropic glutamate receptors (mGluRs) have been implicated in the disease. We have established the localization of the group III mGluR subtype, mGluR8, in the human body and investigated the biol...

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Veröffentlicht in:	Brain research 2007-06, Vol.1152, p.215-227
Hauptverfasser:	Robbins, Melanie J, Starr, Kathryn R, Honey, Andy, Soffin, Ellen M, Rourke, Claire, Jones, Gareth A, Kelly, Fiona M, Strum, Jay, Melarange, Rosemary A, Harris, Andy J, Rocheville, Magalie, Rupniak, Tom, Murdock, Paul R, Jones, Declan N.C, Kew, James N.C, Maycox, Peter R
Format:	Artikel
Sprache:	eng
Schlagworte:	( S)-3,4-DCPG Adult and adolescent clinical studies Amphetamine - pharmacology Animals Anticonvulsants - pharmacology Anxiety - genetics Anxiety - metabolism Autoreceptors - agonists Autoreceptors - biosynthesis Autoreceptors - physiology Benzoates - pharmacology Biological and medical sciences Brain - metabolism Central Nervous System Stimulants - pharmacology Dentate Gyrus - drug effects Dentate Gyrus - physiology Disease Models, Animal Electroshock Glycine - analogs & derivatives Glycine - pharmacology Humans Locomotor activity Male Medical sciences mGluR8 Mice Mice, Knockout Motor Activity - drug effects Neurology Phencyclidine - pharmacology PPI Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Rats Rats, Sprague-Dawley Receptors, Metabotropic Glutamate - agonists Receptors, Metabotropic Glutamate - genetics Receptors, Metabotropic Glutamate - physiology Schizophrenia Schizophrenia - metabolism Schizophrenia - physiopathology Seizures - etiology Seizures - prevention & control Synapses - physiology Synaptic Transmission - drug effects
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