Protein kinase A phosphorylation of the multifunctional protein CAD antagonizes activation by the MAP kinase cascade

The flux through the de novo pyrimidine biosynthetic pathway is controlled by the multifunctional protein CAD, which catalyzes the first three steps. The cell cycle dependent regulation of pyrimidine biosynthesis is a consequence of sequential phosphorylation of CAD Thr456 and Ser1406 by the MAP kin...

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Veröffentlicht in:	Molecular and cellular biochemistry 2007-07, Vol.301 (1-2), p.69-81
Hauptverfasser:	Kotsis, Damian H, Masko, Elizabeth M, Sigoillot, Frederic D, Gregorio, Roberto Di, Guy-Evans, Hedeel I, Evans, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartate Carbamoyltransferase - metabolism Biosynthesis CAD cAMP-dependent protein kinase Carbamoyl phosphate synthetase Carbamoyl-Phosphate Synthase (Ammonia) - metabolism Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) - metabolism Cell cycle Cell Line Cell signaling Colforsin - metabolism Cricetinae Cricetulus Cyclic AMP-Dependent Protein Kinases - metabolism Dihydroorotase - metabolism Enzyme Activation Enzyme Inhibitors - metabolism Enzymes Epidermal Growth Factor - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Forskolin Kinases MAP kinase MAP Kinase Signaling System - physiology mitogen-activated protein kinase Phosphorylation Proliferation Protein kinase A Protein Subunits - metabolism Proteins Pyrimidine biosynthesis
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