Multifunctional tellurium molecule protects and restores dopaminergic neurons in Parkinson's disease models

In Parkinson's disease (PD) dopaminergic neurons in the substantia nigra (SN) become dysfunctional and many ultimately die. We report that the tellurium immunomodulating compound ammonium trichloro(dioxoethylene-O,O'-)tellurate(AS101) protects dopaminergic neurons and improves motor functi...

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Veröffentlicht in:	The FASEB journal 2007-06, Vol.21 (8), p.1870-1883
Hauptverfasser:	Sredni, Benjamin, Geffen-Aricha, Revital, Duan, Wenzhen, Albeck, Michael, Shalit, Frances, Lander, Harry M, Kinor, Noa, Sagi, Ortal, Albeck, Amnon, Yosef, Sigal, Brodsky, Miri, Sredni-Kenigsbuch, Dvora, Sonino, Tali, Longo, Dan L, Mattson, Mark P, Yadid, Gal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Animals apoptosis Apoptosis - drug effects Cells, Cultured cytokines Disease Models, Animal Dopamine Ethylenes - pharmacology Inflammation Male Mice Mice, Inbred C57BL Motor Activity - drug effects Neurons - pathology neuroprotection neurotrophic Parkinson Disease - drug therapy Parkinson Disease - pathology Protective Agents - pharmacology Rats Rats, Sprague-Dawley Tellurium - pharmacology
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