Interferon Gamma and Interleukin-2 Secretion in Whole Blood Cell Cultures from Small-Cell Lung Cancer Patients
Secretion of interleukin-2 (IL-2) and interferon-γ (IFNγ) in whole blood cell cultures after phytohemagglutinin (PHA) and pokeweed mitogen (PWM) stimulation was evaluated in 42 small-cell lung cancer patients before treatment. Blood cultures from patients with extensive and limited disease have lowe...
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| Veröffentlicht in: | Tumor biology 2001-03, Vol.22 (2), p.72-76 |
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| creator | Szopiński, J. von Kleist, S. Rowińska-Zakrzewska, E. Panorska, A. Rogińska, E. Rogala, E. |
| description | Secretion of interleukin-2 (IL-2) and interferon-γ (IFNγ) in whole blood cell cultures after phytohemagglutinin (PHA) and pokeweed mitogen (PWM) stimulation was evaluated in 42 small-cell lung cancer patients before treatment. Blood cultures from patients with extensive and limited disease have lower IFNγ secretions after PWM stimulation and lower IL-2 secretions after PWM and PHA stimulation, but this was not statistically significant. IFNγ but not IL-2 secretion was significantly higher after PWM stimulation in cultures from patients with better clinical performance status (0 + 1, WHO scale). Blood cultures from patients with tumor regression after treatment had a higher secretion of IFNγ after PWM stimulation. In contrast, blood cultures from patients with a poor prognosis had significantly lower IL-2 and IFNγ secretions after stimulation with PWM, and a lower IL-2 secretion after stimulation with PHA. |
| doi_str_mv | 10.1159/000050599 |
| format | Article |
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Blood cultures from patients with extensive and limited disease have lower IFNγ secretions after PWM stimulation and lower IL-2 secretions after PWM and PHA stimulation, but this was not statistically significant. IFNγ but not IL-2 secretion was significantly higher after PWM stimulation in cultures from patients with better clinical performance status (0 + 1, WHO scale). Blood cultures from patients with tumor regression after treatment had a higher secretion of IFNγ after PWM stimulation. In contrast, blood cultures from patients with a poor prognosis had significantly lower IL-2 and IFNγ secretions after stimulation with PWM, and a lower IL-2 secretion after stimulation with PHA.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1159/000050599</identifier><identifier>PMID: 11125278</identifier><identifier>CODEN: OBIMD4</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Carcinoma, Small Cell - blood ; Carcinoma, Small Cell - metabolism ; Carcinoma, Small Cell - mortality ; Disease Progression ; Female ; Humans ; Interferon-gamma - blood ; Interleukin-2 - blood ; Lung cancer ; Lung Neoplasms - blood ; Lung Neoplasms - metabolism ; Lung Neoplasms - mortality ; Male ; Medical sciences ; Middle Aged ; Phytohemagglutinins - pharmacology ; Pneumology ; Pokeweed Mitogens - pharmacology ; Prognosis ; Research Article ; Treatment Outcome ; Tumors of the respiratory system and mediastinum</subject><ispartof>Tumor biology, 2001-03, Vol.22 (2), p.72-76</ispartof><rights>2001 S. Karger AG, Basel</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2001 S. Karger AG, Basel</rights><rights>Copyright (c) 2001 S. 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Blood cultures from patients with extensive and limited disease have lower IFNγ secretions after PWM stimulation and lower IL-2 secretions after PWM and PHA stimulation, but this was not statistically significant. IFNγ but not IL-2 secretion was significantly higher after PWM stimulation in cultures from patients with better clinical performance status (0 + 1, WHO scale). Blood cultures from patients with tumor regression after treatment had a higher secretion of IFNγ after PWM stimulation. 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Academic</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szopiński, J.</au><au>von Kleist, S.</au><au>Rowińska-Zakrzewska, E.</au><au>Panorska, A.</au><au>Rogińska, E.</au><au>Rogala, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interferon Gamma and Interleukin-2 Secretion in Whole Blood Cell Cultures from Small-Cell Lung Cancer Patients</atitle><jtitle>Tumor biology</jtitle><addtitle>Tumor Biol</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>22</volume><issue>2</issue><spage>72</spage><epage>76</epage><pages>72-76</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><coden>OBIMD4</coden><abstract>Secretion of interleukin-2 (IL-2) and interferon-γ (IFNγ) in whole blood cell cultures after phytohemagglutinin (PHA) and pokeweed mitogen (PWM) stimulation was evaluated in 42 small-cell lung cancer patients before treatment. Blood cultures from patients with extensive and limited disease have lower IFNγ secretions after PWM stimulation and lower IL-2 secretions after PWM and PHA stimulation, but this was not statistically significant. IFNγ but not IL-2 secretion was significantly higher after PWM stimulation in cultures from patients with better clinical performance status (0 + 1, WHO scale). Blood cultures from patients with tumor regression after treatment had a higher secretion of IFNγ after PWM stimulation. In contrast, blood cultures from patients with a poor prognosis had significantly lower IL-2 and IFNγ secretions after stimulation with PWM, and a lower IL-2 secretion after stimulation with PHA.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>11125278</pmid><doi>10.1159/000050599</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Tumor biology, 2001-03, Vol.22 (2), p.72-76 |
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| subjects | Adult Aged Biological and medical sciences Carcinoma, Small Cell - blood Carcinoma, Small Cell - metabolism Carcinoma, Small Cell - mortality Disease Progression Female Humans Interferon-gamma - blood Interleukin-2 - blood Lung cancer Lung Neoplasms - blood Lung Neoplasms - metabolism Lung Neoplasms - mortality Male Medical sciences Middle Aged Phytohemagglutinins - pharmacology Pneumology Pokeweed Mitogens - pharmacology Prognosis Research Article Treatment Outcome Tumors of the respiratory system and mediastinum |
| title | Interferon Gamma and Interleukin-2 Secretion in Whole Blood Cell Cultures from Small-Cell Lung Cancer Patients |
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