Risk factors for the progression of coronary artery calcification in asymptomatic subjects : Results from the multi-ethnic study of atherosclerosis (MESA)
The Multi-Ethnic Study of Atherosclerosis (MESA) provides an opportunity to study the association of traditional cardiovascular risk factors with the incidence and progression of coronary artery calcium (CAC) in a large community-based cohort with no evidence of clinical cardiovascular disease. Foll...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2007-05, Vol.115 (21), p.2722-2730 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | KRONMAL, Richard A MCCLELLAND, Robyn L DETRANO, Robert SHEA, Steven LIMA, Joao A CUSHMAN, Mary BILD, Diane E BURKE, Gregory L |
| description | The Multi-Ethnic Study of Atherosclerosis (MESA) provides an opportunity to study the association of traditional cardiovascular risk factors with the incidence and progression of coronary artery calcium (CAC) in a large community-based cohort with no evidence of clinical cardiovascular disease.
Follow-up CAC measurements were available for 5756 participants with an average of 2.4 years between scans. The incidence of newly detectable CAC averaged 6.6% per year. Incidence increased steadily across age, ranging from 80 years of age. Median annual change in CAC for those with existing calcification at baseline was 14 Agatston units for women and 21 Agatston units for men. Most traditional cardiovascular risk factors were associated with both the risk of developing new incident coronary calcium and increases in existing calcification. These included age, male gender, white race/ethnicity, hypertension, body mass index, diabetes mellitus, glucose, and family history of heart attack. Factors also existed that were related only to incident CAC risk, such as low- and high-density lipoprotein cholesterol and creatinine. Diabetes mellitus had the strongest association with CAC progression for blacks and the weakest for Hispanics, with intermediate associations for whites and Chinese.
This is the first large multiethnic study reporting on the incidence and progression of CAC. Standard coronary risk factors were generally related to both CAC incidence and progression. Whites had more incident CAC and CAC progression than the other 3 racial/ethnic groups. Except for diabetes mellitus, risk factor relationships were similar across racial/ethnic groups. |
| doi_str_mv | 10.1161/CIRCULATIONAHA.106.674143 |
| format | Article |
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Follow-up CAC measurements were available for 5756 participants with an average of 2.4 years between scans. The incidence of newly detectable CAC averaged 6.6% per year. Incidence increased steadily across age, ranging from <5% annually in those <50 years of age to >12% in those >80 years of age. Median annual change in CAC for those with existing calcification at baseline was 14 Agatston units for women and 21 Agatston units for men. Most traditional cardiovascular risk factors were associated with both the risk of developing new incident coronary calcium and increases in existing calcification. These included age, male gender, white race/ethnicity, hypertension, body mass index, diabetes mellitus, glucose, and family history of heart attack. Factors also existed that were related only to incident CAC risk, such as low- and high-density lipoprotein cholesterol and creatinine. Diabetes mellitus had the strongest association with CAC progression for blacks and the weakest for Hispanics, with intermediate associations for whites and Chinese.
This is the first large multiethnic study reporting on the incidence and progression of CAC. Standard coronary risk factors were generally related to both CAC incidence and progression. Whites had more incident CAC and CAC progression than the other 3 racial/ethnic groups. Except for diabetes mellitus, risk factor relationships were similar across racial/ethnic groups.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/CIRCULATIONAHA.106.674143</identifier><identifier>PMID: 17502571</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Calcinosis - epidemiology ; Calcinosis - pathology ; Cardiology. Vascular system ; Cohort Studies ; Continental Population Groups ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - etiology ; Coronary Artery Disease - pathology ; Coronary heart disease ; Coronary Vessels - pathology ; Disease Progression ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Ethnic Groups ; Female ; Heart ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; Risk Factors</subject><ispartof>Circulation (New York, N.Y.), 2007-05, Vol.115 (21), p.2722-2730</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c363t-bec420d8ef1d3ec46360e055f7e5fd480fea5197cf654154d0a0c02da6adc7ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3686,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18833549$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17502571$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KRONMAL, Richard A</creatorcontrib><creatorcontrib>MCCLELLAND, Robyn L</creatorcontrib><creatorcontrib>DETRANO, Robert</creatorcontrib><creatorcontrib>SHEA, Steven</creatorcontrib><creatorcontrib>LIMA, Joao A</creatorcontrib><creatorcontrib>CUSHMAN, Mary</creatorcontrib><creatorcontrib>BILD, Diane E</creatorcontrib><creatorcontrib>BURKE, Gregory L</creatorcontrib><title>Risk factors for the progression of coronary artery calcification in asymptomatic subjects : Results from the multi-ethnic study of atherosclerosis (MESA)</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>The Multi-Ethnic Study of Atherosclerosis (MESA) provides an opportunity to study the association of traditional cardiovascular risk factors with the incidence and progression of coronary artery calcium (CAC) in a large community-based cohort with no evidence of clinical cardiovascular disease.
Follow-up CAC measurements were available for 5756 participants with an average of 2.4 years between scans. The incidence of newly detectable CAC averaged 6.6% per year. Incidence increased steadily across age, ranging from <5% annually in those <50 years of age to >12% in those >80 years of age. Median annual change in CAC for those with existing calcification at baseline was 14 Agatston units for women and 21 Agatston units for men. Most traditional cardiovascular risk factors were associated with both the risk of developing new incident coronary calcium and increases in existing calcification. These included age, male gender, white race/ethnicity, hypertension, body mass index, diabetes mellitus, glucose, and family history of heart attack. Factors also existed that were related only to incident CAC risk, such as low- and high-density lipoprotein cholesterol and creatinine. Diabetes mellitus had the strongest association with CAC progression for blacks and the weakest for Hispanics, with intermediate associations for whites and Chinese.
This is the first large multiethnic study reporting on the incidence and progression of CAC. Standard coronary risk factors were generally related to both CAC incidence and progression. Whites had more incident CAC and CAC progression than the other 3 racial/ethnic groups. Except for diabetes mellitus, risk factor relationships were similar across racial/ethnic groups.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Calcinosis - epidemiology</subject><subject>Calcinosis - pathology</subject><subject>Cardiology. Vascular system</subject><subject>Cohort Studies</subject><subject>Continental Population Groups</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - etiology</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary heart disease</subject><subject>Coronary Vessels - pathology</subject><subject>Disease Progression</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Ethnic Groups</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAUhi1ERYfCKyCzoIJFBt-TsItGhY40UGlo15HHsalLEg8-zmJepU-Lw4xUdcXG5-Lv_Nbxj9B7SpaUKvp5td6u7jbN7frmR3PdLClRS1UKKvgLtKCSiUJIXr9EC0JIXZScsXP0GuAhl4qX8hU6p6UkTJZ0gR63Hn5jp00KEbALEad7i_cx_IoWwIcRB4dNiGHU8YB1TDYHo3vjnTc6zYAfsYbDsE9hyA2DYdo9WJMAf8FbC1OfMxfD8E94yKUvbLofZzBN3WHW1_kqBjD9fHrAH79f_Ww-vUFnTvdg357iBbr7enW7ui42N9_Wq2ZTGK54KnbWCEa6yjra8ZwrroglUrrSSteJijirJa1L45QUVIqOaGII67TSnSm15Rfo8qibt_4zWUjt4MHYvtejDRO0JZGKiEr-F2SEKaYUy2B9BE3eB6J17T76IX9gS0k7O9g-dzC3VXt0MM--Oz0y7QbbPU2eLMvAhxOgIRvhoh6NhyeuqjiXouZ_AU5nqaA</recordid><startdate>20070529</startdate><enddate>20070529</enddate><creator>KRONMAL, Richard A</creator><creator>MCCLELLAND, Robyn L</creator><creator>DETRANO, Robert</creator><creator>SHEA, Steven</creator><creator>LIMA, Joao A</creator><creator>CUSHMAN, Mary</creator><creator>BILD, Diane E</creator><creator>BURKE, Gregory L</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20070529</creationdate><title>Risk factors for the progression of coronary artery calcification in asymptomatic subjects : Results from the multi-ethnic study of atherosclerosis (MESA)</title><author>KRONMAL, Richard A ; MCCLELLAND, Robyn L ; DETRANO, Robert ; SHEA, Steven ; LIMA, Joao A ; CUSHMAN, Mary ; BILD, Diane E ; BURKE, Gregory L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-bec420d8ef1d3ec46360e055f7e5fd480fea5197cf654154d0a0c02da6adc7ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Calcinosis - epidemiology</topic><topic>Calcinosis - pathology</topic><topic>Cardiology. Vascular system</topic><topic>Cohort Studies</topic><topic>Continental Population Groups</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - etiology</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary heart disease</topic><topic>Coronary Vessels - pathology</topic><topic>Disease Progression</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Ethnic Groups</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KRONMAL, Richard A</creatorcontrib><creatorcontrib>MCCLELLAND, Robyn L</creatorcontrib><creatorcontrib>DETRANO, Robert</creatorcontrib><creatorcontrib>SHEA, Steven</creatorcontrib><creatorcontrib>LIMA, Joao A</creatorcontrib><creatorcontrib>CUSHMAN, Mary</creatorcontrib><creatorcontrib>BILD, Diane E</creatorcontrib><creatorcontrib>BURKE, Gregory L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KRONMAL, Richard A</au><au>MCCLELLAND, Robyn L</au><au>DETRANO, Robert</au><au>SHEA, Steven</au><au>LIMA, Joao A</au><au>CUSHMAN, Mary</au><au>BILD, Diane E</au><au>BURKE, Gregory L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for the progression of coronary artery calcification in asymptomatic subjects : Results from the multi-ethnic study of atherosclerosis (MESA)</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2007-05-29</date><risdate>2007</risdate><volume>115</volume><issue>21</issue><spage>2722</spage><epage>2730</epage><pages>2722-2730</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>The Multi-Ethnic Study of Atherosclerosis (MESA) provides an opportunity to study the association of traditional cardiovascular risk factors with the incidence and progression of coronary artery calcium (CAC) in a large community-based cohort with no evidence of clinical cardiovascular disease.
Follow-up CAC measurements were available for 5756 participants with an average of 2.4 years between scans. The incidence of newly detectable CAC averaged 6.6% per year. Incidence increased steadily across age, ranging from <5% annually in those <50 years of age to >12% in those >80 years of age. Median annual change in CAC for those with existing calcification at baseline was 14 Agatston units for women and 21 Agatston units for men. Most traditional cardiovascular risk factors were associated with both the risk of developing new incident coronary calcium and increases in existing calcification. These included age, male gender, white race/ethnicity, hypertension, body mass index, diabetes mellitus, glucose, and family history of heart attack. Factors also existed that were related only to incident CAC risk, such as low- and high-density lipoprotein cholesterol and creatinine. Diabetes mellitus had the strongest association with CAC progression for blacks and the weakest for Hispanics, with intermediate associations for whites and Chinese.
This is the first large multiethnic study reporting on the incidence and progression of CAC. Standard coronary risk factors were generally related to both CAC incidence and progression. Whites had more incident CAC and CAC progression than the other 3 racial/ethnic groups. Except for diabetes mellitus, risk factor relationships were similar across racial/ethnic groups.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>17502571</pmid><doi>10.1161/CIRCULATIONAHA.106.674143</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Circulation (New York, N.Y.), 2007-05, Vol.115 (21), p.2722-2730 |
| issn | 0009-7322 1524-4539 |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Age Factors Aged Aged, 80 and over Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Calcinosis - epidemiology Calcinosis - pathology Cardiology. Vascular system Cohort Studies Continental Population Groups Coronary Artery Disease - epidemiology Coronary Artery Disease - etiology Coronary Artery Disease - pathology Coronary heart disease Coronary Vessels - pathology Disease Progression Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Ethnic Groups Female Heart Humans Incidence Male Medical sciences Middle Aged Risk Factors |
| title | Risk factors for the progression of coronary artery calcification in asymptomatic subjects : Results from the multi-ethnic study of atherosclerosis (MESA) |
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