Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell
Abstract CD44s is a principle hyaluronate (HA) receptor and has been reported to play an important role in cancer cell invasion and metastasis. The aim of our study is to determine if the interaction between HA and CD44s influences in vitro chemosensitivity of non-small cell lung cancer (NSCLC). NSC...
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| Veröffentlicht in: | Cancer letters 2007-07, Vol.252 (2), p.225-234 |
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| container_title | Cancer letters |
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| creator | Ohashi, Rina Takahashi, Fumiyuki Cui, Ri Yoshioka, Masakata Gu, Tao Sasaki, Shinichi Tominaga, Shigeru Nishio, Kazuto Tanabe, Kenneth K Takahashi, Kazuhisa |
| description | Abstract CD44s is a principle hyaluronate (HA) receptor and has been reported to play an important role in cancer cell invasion and metastasis. The aim of our study is to determine if the interaction between HA and CD44s influences in vitro chemosensitivity of non-small cell lung cancer (NSCLC). NSCLC cell line, H322 cells, transfected with the CD44s gene (H322/CD44s) cultured on HA coated plates were more resistant to cisplatin (CDDP) than that on bovine serum albumin. Multidrug resistance protein2 (MRP2) expression was induced in H322/CD44s cells cultured on HA. MRP2 inhibitor, MK571, not only suppressed MRP2 expression but also reversed CDDP resistance. These results suggest that the interaction between CD44s and HA play a pivotal role in acquired resistance to CDDP in NSCLC and MRP2 could be involved in this potential mechanism. |
| doi_str_mv | 10.1016/j.canlet.2006.12.025 |
| format | Article |
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The aim of our study is to determine if the interaction between HA and CD44s influences in vitro chemosensitivity of non-small cell lung cancer (NSCLC). NSCLC cell line, H322 cells, transfected with the CD44s gene (H322/CD44s) cultured on HA coated plates were more resistant to cisplatin (CDDP) than that on bovine serum albumin. Multidrug resistance protein2 (MRP2) expression was induced in H322/CD44s cells cultured on HA. MRP2 inhibitor, MK571, not only suppressed MRP2 expression but also reversed CDDP resistance. These results suggest that the interaction between CD44s and HA play a pivotal role in acquired resistance to CDDP in NSCLC and MRP2 could be involved in this potential mechanism.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2006.12.025</identifier><identifier>PMID: 17276588</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Acquisitions & mergers ; Apoptosis ; Binding sites ; Blotting, Western ; Cancer therapies ; Carcinoma, Non-Small-Cell Lung - metabolism ; Carcinoma, Non-Small-Cell Lung - pathology ; CD44s ; Cell Adhesion ; Cell Line, Tumor ; Chemoresistance ; Deoxyribonucleic acid ; DNA ; DNA repair ; Drug resistance ; Drug Resistance, Multiple ; Fluorescent Antibody Technique ; Hematology, Oncology and Palliative Medicine ; Humans ; Hyaluronan Receptors - metabolism ; Hyaluronate ; Hyaluronic Acid - metabolism ; In Situ Nick-End Labeling ; Lung cancer ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Medical prognosis ; Membrane Transport Proteins - metabolism ; Molecular weight ; MRP2 ; Multidrug Resistance-Associated Proteins - antagonists & inhibitors ; Multidrug Resistance-Associated Proteins - metabolism ; Non-small cell lung cancer ; Proteins</subject><ispartof>Cancer letters, 2007-07, Vol.252 (2), p.225-234</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2007 Elsevier Ireland Ltd</rights><rights>Copyright Elsevier Limited Jul 18, 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-ca3214cd7be5e6509c24154a3c29d58207d0aec6d17d92416a8321a8a0baeb5b3</citedby><cites>FETCH-LOGICAL-c509t-ca3214cd7be5e6509c24154a3c29d58207d0aec6d17d92416a8321a8a0baeb5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304383506007026$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17276588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohashi, Rina</creatorcontrib><creatorcontrib>Takahashi, Fumiyuki</creatorcontrib><creatorcontrib>Cui, Ri</creatorcontrib><creatorcontrib>Yoshioka, Masakata</creatorcontrib><creatorcontrib>Gu, Tao</creatorcontrib><creatorcontrib>Sasaki, Shinichi</creatorcontrib><creatorcontrib>Tominaga, Shigeru</creatorcontrib><creatorcontrib>Nishio, Kazuto</creatorcontrib><creatorcontrib>Tanabe, Kenneth K</creatorcontrib><creatorcontrib>Takahashi, Kazuhisa</creatorcontrib><title>Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Abstract CD44s is a principle hyaluronate (HA) receptor and has been reported to play an important role in cancer cell invasion and metastasis. The aim of our study is to determine if the interaction between HA and CD44s influences in vitro chemosensitivity of non-small cell lung cancer (NSCLC). NSCLC cell line, H322 cells, transfected with the CD44s gene (H322/CD44s) cultured on HA coated plates were more resistant to cisplatin (CDDP) than that on bovine serum albumin. Multidrug resistance protein2 (MRP2) expression was induced in H322/CD44s cells cultured on HA. MRP2 inhibitor, MK571, not only suppressed MRP2 expression but also reversed CDDP resistance. These results suggest that the interaction between CD44s and HA play a pivotal role in acquired resistance to CDDP in NSCLC and MRP2 could be involved in this potential mechanism.</description><subject>Acquisitions & mergers</subject><subject>Apoptosis</subject><subject>Binding sites</subject><subject>Blotting, Western</subject><subject>Cancer therapies</subject><subject>Carcinoma, Non-Small-Cell Lung - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>CD44s</subject><subject>Cell Adhesion</subject><subject>Cell Line, Tumor</subject><subject>Chemoresistance</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA repair</subject><subject>Drug resistance</subject><subject>Drug Resistance, Multiple</subject><subject>Fluorescent Antibody Technique</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Hyaluronan Receptors - metabolism</subject><subject>Hyaluronate</subject><subject>Hyaluronic Acid - metabolism</subject><subject>In Situ Nick-End Labeling</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Medical prognosis</subject><subject>Membrane Transport Proteins - metabolism</subject><subject>Molecular weight</subject><subject>MRP2</subject><subject>Multidrug Resistance-Associated Proteins - antagonists & inhibitors</subject><subject>Multidrug Resistance-Associated Proteins - metabolism</subject><subject>Non-small cell lung cancer</subject><subject>Proteins</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUsFq3DAQFaWh2ab9g1IMhdzsjmTLsi-FskmTQCCHtmchjyaNtracSnLL_n3l7kIgl14kePPeaPTeMPaOQ8WBtx93FRo_UqoEQFtxUYGQL9iGd0qUqu_gJdtADU1Zd7U8Za9j3AGAbJR8xU65EqqVXbdheOMTBYPJzb4YKP0h8sX2omkK423xsDfjEmZvEhXO2wUpFvhA0xwoupiMxxUv_OzLOJlxLJDyMS7-R4FrMfwD3rCTezNGenu8z9j3L5ffttfl7d3VzfbzbYkS-lSiqQVv0KqBJLUZQtFw2ZgaRW9lJ0BZMISt5cr2udSaLgtMZ2AwNMihPmPnh76PYf61UEx6cnEdwHial6gVSNk3ss_ED8-Iu3kJPs-mucweSVW3IrOaAwvDHGOge_0Y3GTCXnPQawR6pw8R6DUCzYXOEWTZ-2PzZZjIPomOnmfCpwOBshe_HQUd0VF2y7pAmLSd3f9eeN4AR-cdmvEn7Sk-_UXHLNBf1zVYtwBaAAWirf8CYVCt9A</recordid><startdate>20070718</startdate><enddate>20070718</enddate><creator>Ohashi, Rina</creator><creator>Takahashi, Fumiyuki</creator><creator>Cui, Ri</creator><creator>Yoshioka, Masakata</creator><creator>Gu, Tao</creator><creator>Sasaki, Shinichi</creator><creator>Tominaga, Shigeru</creator><creator>Nishio, Kazuto</creator><creator>Tanabe, Kenneth K</creator><creator>Takahashi, Kazuhisa</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20070718</creationdate><title>Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell</title><author>Ohashi, Rina ; Takahashi, Fumiyuki ; Cui, Ri ; Yoshioka, Masakata ; Gu, Tao ; Sasaki, Shinichi ; Tominaga, Shigeru ; Nishio, Kazuto ; Tanabe, Kenneth K ; Takahashi, Kazuhisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-ca3214cd7be5e6509c24154a3c29d58207d0aec6d17d92416a8321a8a0baeb5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acquisitions & mergers</topic><topic>Apoptosis</topic><topic>Binding sites</topic><topic>Blotting, Western</topic><topic>Cancer therapies</topic><topic>Carcinoma, Non-Small-Cell Lung - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>CD44s</topic><topic>Cell Adhesion</topic><topic>Cell Line, Tumor</topic><topic>Chemoresistance</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA repair</topic><topic>Drug resistance</topic><topic>Drug Resistance, Multiple</topic><topic>Fluorescent Antibody Technique</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Hyaluronan Receptors - metabolism</topic><topic>Hyaluronate</topic><topic>Hyaluronic Acid - metabolism</topic><topic>In Situ Nick-End Labeling</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Medical prognosis</topic><topic>Membrane Transport Proteins - metabolism</topic><topic>Molecular weight</topic><topic>MRP2</topic><topic>Multidrug Resistance-Associated Proteins - antagonists & inhibitors</topic><topic>Multidrug Resistance-Associated Proteins - metabolism</topic><topic>Non-small cell lung cancer</topic><topic>Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohashi, Rina</creatorcontrib><creatorcontrib>Takahashi, Fumiyuki</creatorcontrib><creatorcontrib>Cui, Ri</creatorcontrib><creatorcontrib>Yoshioka, Masakata</creatorcontrib><creatorcontrib>Gu, Tao</creatorcontrib><creatorcontrib>Sasaki, Shinichi</creatorcontrib><creatorcontrib>Tominaga, Shigeru</creatorcontrib><creatorcontrib>Nishio, Kazuto</creatorcontrib><creatorcontrib>Tanabe, Kenneth K</creatorcontrib><creatorcontrib>Takahashi, Kazuhisa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohashi, Rina</au><au>Takahashi, Fumiyuki</au><au>Cui, Ri</au><au>Yoshioka, Masakata</au><au>Gu, Tao</au><au>Sasaki, Shinichi</au><au>Tominaga, Shigeru</au><au>Nishio, Kazuto</au><au>Tanabe, Kenneth K</au><au>Takahashi, Kazuhisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2007-07-18</date><risdate>2007</risdate><volume>252</volume><issue>2</issue><spage>225</spage><epage>234</epage><pages>225-234</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Abstract CD44s is a principle hyaluronate (HA) receptor and has been reported to play an important role in cancer cell invasion and metastasis. The aim of our study is to determine if the interaction between HA and CD44s influences in vitro chemosensitivity of non-small cell lung cancer (NSCLC). NSCLC cell line, H322 cells, transfected with the CD44s gene (H322/CD44s) cultured on HA coated plates were more resistant to cisplatin (CDDP) than that on bovine serum albumin. Multidrug resistance protein2 (MRP2) expression was induced in H322/CD44s cells cultured on HA. MRP2 inhibitor, MK571, not only suppressed MRP2 expression but also reversed CDDP resistance. These results suggest that the interaction between CD44s and HA play a pivotal role in acquired resistance to CDDP in NSCLC and MRP2 could be involved in this potential mechanism.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>17276588</pmid><doi>10.1016/j.canlet.2006.12.025</doi><tpages>10</tpages></addata></record> |
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| ispartof | Cancer letters, 2007-07, Vol.252 (2), p.225-234 |
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| language | eng |
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| subjects | Acquisitions & mergers Apoptosis Binding sites Blotting, Western Cancer therapies Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology CD44s Cell Adhesion Cell Line, Tumor Chemoresistance Deoxyribonucleic acid DNA DNA repair Drug resistance Drug Resistance, Multiple Fluorescent Antibody Technique Hematology, Oncology and Palliative Medicine Humans Hyaluronan Receptors - metabolism Hyaluronate Hyaluronic Acid - metabolism In Situ Nick-End Labeling Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - pathology Medical prognosis Membrane Transport Proteins - metabolism Molecular weight MRP2 Multidrug Resistance-Associated Proteins - antagonists & inhibitors Multidrug Resistance-Associated Proteins - metabolism Non-small cell lung cancer Proteins |
| title | Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell |
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