Orexin neuronal changes in the locus coeruleus of the aging rhesus macaque

Abstract Orexin neuropeptides regulate arousal state and excite the noradrenergic locus coeruleus (LC), so it is plausible that an age-related loss of orexin neurons and projections to the LC contributes to poor sleep quality in elderly humans and nonhuman primates. To test this hypothesis we examin...

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Veröffentlicht in:	Neurobiology of aging 2007-08, Vol.28 (8), p.1286-1295
Hauptverfasser:	Downs, Jodi L, Dunn, Michael R, Borok, Erzsebet, Shanabrough, Marya, Horvath, Tamas L, Kohama, Steven G, Urbanski, Henryk F
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aging Aging - physiology Analysis of Variance Animals Axon density Hypocretin Hypothalamic Area, Lateral - metabolism In Situ Hybridization - methods Internal Medicine Intracellular Signaling Peptides and Proteins - blood Intracellular Signaling Peptides and Proteins - metabolism Lateral hypothalamic area (LHA) Locus coeruleus (LC) Locus Coeruleus - cytology Macaca mulatta Macaca mulatta - physiology Male Neurology Neurons - metabolism Neuropeptides - blood Neuropeptides - metabolism Orexin Orexins Primate Primates Rhesus macaque Tyrosine 3-Monooxygenase - metabolism Tyrosine hydroxylase
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