Change of cross-linked telopeptide of type I collagen (ICTP) and other bone resorption markers in patients with bone fragility fractures
The serum concentration of cross-linked telo-peptide of type I collagen (ICTP) has been reported to be a useful marker and for both diagnosis and monitoring of bone metastasis. This study was performed to clarify the changes in various bone turnover markers, including ICTP, after bone fragility frac...
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| Veröffentlicht in: | Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2007-05, Vol.12 (3), p.219-226 |
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| creator | Takahara, Kenji Kamimura, Mikio Hashidate, Hiroyuki Uchiyama, Shigeharu Nakagawa, Hiroyuki |
| description | The serum concentration of cross-linked telo-peptide of type I collagen (ICTP) has been reported to be a useful marker and for both diagnosis and monitoring of bone metastasis. This study was performed to clarify the changes in various bone turnover markers, including ICTP, after bone fragility fracture.
Seventy-six bone fragility fracture patients (14 men and 62 postmenopausal women; mean age, 77.0 years) were evaluated for bone resorption markers, including serum ICTP. We measured urinary N-terminal telopeptides of type I collagen (NTX) several times after fracture. Furthermore, serum ICTP, serum NTX, urinary deoxypyridinoline (DPD), and urinary C-telopeptide-cross-linked type I collagen (CTX) were measured at the times of both minimum and maximum urinary NTX.
Urinary NTX was increased significantly from 86.4 ± 57.9 to 214.3 ± 137.2nmol BCE/mmol Cr following fracture. Serum ICTP showed a similar significant increase from 7.6 ± 4.7 to 10.4 ± 5.5 ng/ml in bone fragility fracture patients. Furthermore, other markers also showed similar increases. The level of increase in urinary NTX (148.0%) was especially high compared with other bone resorption markers. On the other hand, the level of increase in serum ICTP (36.8%) was similar to that in serum NTX (39.8%). Serum ICTP levels were significantly correlated with other bone resorption markers, with an especially strong correlation between serum ICTP and serum NTX (r = 0.647, P < 0.001). The percentage of cases in which ICTP exceeded the cutoff value for suspected bone metastasis in postmenopausal women was 73.6%.
The value of ICTP increases with bone fragility fracture and is correlated with other bone resorption markers, and ICTP obviously exceeded the reference value as compared with other bone resorption markers. |
| doi_str_mv | 10.1007/s00776-007-1113-6 |
| format | Article |
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Seventy-six bone fragility fracture patients (14 men and 62 postmenopausal women; mean age, 77.0 years) were evaluated for bone resorption markers, including serum ICTP. We measured urinary N-terminal telopeptides of type I collagen (NTX) several times after fracture. Furthermore, serum ICTP, serum NTX, urinary deoxypyridinoline (DPD), and urinary C-telopeptide-cross-linked type I collagen (CTX) were measured at the times of both minimum and maximum urinary NTX.
Urinary NTX was increased significantly from 86.4 ± 57.9 to 214.3 ± 137.2nmol BCE/mmol Cr following fracture. Serum ICTP showed a similar significant increase from 7.6 ± 4.7 to 10.4 ± 5.5 ng/ml in bone fragility fracture patients. Furthermore, other markers also showed similar increases. The level of increase in urinary NTX (148.0%) was especially high compared with other bone resorption markers. On the other hand, the level of increase in serum ICTP (36.8%) was similar to that in serum NTX (39.8%). Serum ICTP levels were significantly correlated with other bone resorption markers, with an especially strong correlation between serum ICTP and serum NTX (r = 0.647, P < 0.001). The percentage of cases in which ICTP exceeded the cutoff value for suspected bone metastasis in postmenopausal women was 73.6%.
The value of ICTP increases with bone fragility fracture and is correlated with other bone resorption markers, and ICTP obviously exceeded the reference value as compared with other bone resorption markers.</description><identifier>ISSN: 0949-2658</identifier><identifier>EISSN: 1436-2023</identifier><identifier>DOI: 10.1007/s00776-007-1113-6</identifier><identifier>PMID: 17530373</identifier><language>eng</language><publisher>Japan: Elsevier B.V</publisher><subject>Aged ; Aged, 80 and over ; Amino Acids - urine ; Biomarkers - blood ; Biomarkers - urine ; Bone Neoplasms - complications ; Bone Neoplasms - metabolism ; Bone Neoplasms - secondary ; Bone Resorption - complications ; Bone Resorption - metabolism ; Collagen Type I - urine ; Female ; Femoral Fractures - etiology ; Femoral Fractures - metabolism ; Fractures, Spontaneous - etiology ; Fractures, Spontaneous - metabolism ; Humans ; Male ; Middle Aged ; Osteoporosis, Postmenopausal - complications ; Osteoporosis, Postmenopausal - metabolism ; Pelvic Bones - injuries ; Peptide Fragments - blood ; Peptides - urine ; Procollagen - blood ; Radioimmunoassay ; Severity of Illness Index</subject><ispartof>Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2007-05, Vol.12 (3), p.219-226</ispartof><rights>2007 The Japanese Orthopaedic Association</rights><rights>The Japanese Orthopaedic Association 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-9d1b41a53854d55652de9e2ac9a50b13d292d6126a7b4f299aab187ee97d0ade3</citedby><cites>FETCH-LOGICAL-c431t-9d1b41a53854d55652de9e2ac9a50b13d292d6126a7b4f299aab187ee97d0ade3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17530373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takahara, Kenji</creatorcontrib><creatorcontrib>Kamimura, Mikio</creatorcontrib><creatorcontrib>Hashidate, Hiroyuki</creatorcontrib><creatorcontrib>Uchiyama, Shigeharu</creatorcontrib><creatorcontrib>Nakagawa, Hiroyuki</creatorcontrib><title>Change of cross-linked telopeptide of type I collagen (ICTP) and other bone resorption markers in patients with bone fragility fractures</title><title>Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association</title><addtitle>J Orthop Sci</addtitle><description>The serum concentration of cross-linked telo-peptide of type I collagen (ICTP) has been reported to be a useful marker and for both diagnosis and monitoring of bone metastasis. This study was performed to clarify the changes in various bone turnover markers, including ICTP, after bone fragility fracture.
Seventy-six bone fragility fracture patients (14 men and 62 postmenopausal women; mean age, 77.0 years) were evaluated for bone resorption markers, including serum ICTP. We measured urinary N-terminal telopeptides of type I collagen (NTX) several times after fracture. Furthermore, serum ICTP, serum NTX, urinary deoxypyridinoline (DPD), and urinary C-telopeptide-cross-linked type I collagen (CTX) were measured at the times of both minimum and maximum urinary NTX.
Urinary NTX was increased significantly from 86.4 ± 57.9 to 214.3 ± 137.2nmol BCE/mmol Cr following fracture. Serum ICTP showed a similar significant increase from 7.6 ± 4.7 to 10.4 ± 5.5 ng/ml in bone fragility fracture patients. Furthermore, other markers also showed similar increases. The level of increase in urinary NTX (148.0%) was especially high compared with other bone resorption markers. On the other hand, the level of increase in serum ICTP (36.8%) was similar to that in serum NTX (39.8%). Serum ICTP levels were significantly correlated with other bone resorption markers, with an especially strong correlation between serum ICTP and serum NTX (r = 0.647, P < 0.001). The percentage of cases in which ICTP exceeded the cutoff value for suspected bone metastasis in postmenopausal women was 73.6%.
The value of ICTP increases with bone fragility fracture and is correlated with other bone resorption markers, and ICTP obviously exceeded the reference value as compared with other bone resorption markers.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amino Acids - urine</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>Bone Neoplasms - complications</subject><subject>Bone Neoplasms - metabolism</subject><subject>Bone Neoplasms - secondary</subject><subject>Bone Resorption - complications</subject><subject>Bone Resorption - metabolism</subject><subject>Collagen Type I - urine</subject><subject>Female</subject><subject>Femoral Fractures - etiology</subject><subject>Femoral Fractures - metabolism</subject><subject>Fractures, Spontaneous - etiology</subject><subject>Fractures, Spontaneous - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Osteoporosis, Postmenopausal - complications</subject><subject>Osteoporosis, Postmenopausal - metabolism</subject><subject>Pelvic Bones - injuries</subject><subject>Peptide Fragments - blood</subject><subject>Peptides - urine</subject><subject>Procollagen - blood</subject><subject>Radioimmunoassay</subject><subject>Severity of Illness Index</subject><issn>0949-2658</issn><issn>1436-2023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc2KFDEUhYMoTtv6AG4kuBBdlOanUungShp_GgZ0Ma5DKrnVnZnqpExSSr-Bj216qkFw4ebeC_nOJfcchJ5T8pYSIt_lWmTX1NpQSnnTPUAr2vKuYYTxh2hFVKsa1onNFXqS8y0hVAolHqOr2jnhkq_Q7-3BhD3gOGCbYs7N6MMdOFxgjBNMxbv7t3KaAO-wjeNo9hDw69325tsbbILDsRwg4T4GwAlyTFUTAz6adAcpYx_wZIqHUDL-5cthAYdk9n705XSebJmr8Cl6NJgxw7NLX6Pvnz7ebL80118_77Yfrhvbcloa5WjfUiP4RrROiE4wBwqYscoI0lPumGKuo6wzsm8HppQxPd1IACUdMQ74Gr1a9k4p_pghF3302UK9K0Ccs5ZEiI0kvIIv_wFv45xC_ZtmjCjKZLV6jegC3ZuXYNBT8vX2k6ZEnzPSS0b6PJ4z0l3VvLgsnvsjuL-KSygVeL8AUH346SHpbKuDFpxPYIt20f9n_R_Sh6DO</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Takahara, Kenji</creator><creator>Kamimura, Mikio</creator><creator>Hashidate, Hiroyuki</creator><creator>Uchiyama, Shigeharu</creator><creator>Nakagawa, Hiroyuki</creator><general>Elsevier B.V</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>Change of cross-linked telopeptide of type I collagen (ICTP) and other bone resorption markers in patients with bone fragility fractures</title><author>Takahara, Kenji ; 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This study was performed to clarify the changes in various bone turnover markers, including ICTP, after bone fragility fracture.
Seventy-six bone fragility fracture patients (14 men and 62 postmenopausal women; mean age, 77.0 years) were evaluated for bone resorption markers, including serum ICTP. We measured urinary N-terminal telopeptides of type I collagen (NTX) several times after fracture. Furthermore, serum ICTP, serum NTX, urinary deoxypyridinoline (DPD), and urinary C-telopeptide-cross-linked type I collagen (CTX) were measured at the times of both minimum and maximum urinary NTX.
Urinary NTX was increased significantly from 86.4 ± 57.9 to 214.3 ± 137.2nmol BCE/mmol Cr following fracture. Serum ICTP showed a similar significant increase from 7.6 ± 4.7 to 10.4 ± 5.5 ng/ml in bone fragility fracture patients. Furthermore, other markers also showed similar increases. The level of increase in urinary NTX (148.0%) was especially high compared with other bone resorption markers. On the other hand, the level of increase in serum ICTP (36.8%) was similar to that in serum NTX (39.8%). Serum ICTP levels were significantly correlated with other bone resorption markers, with an especially strong correlation between serum ICTP and serum NTX (r = 0.647, P < 0.001). The percentage of cases in which ICTP exceeded the cutoff value for suspected bone metastasis in postmenopausal women was 73.6%.
The value of ICTP increases with bone fragility fracture and is correlated with other bone resorption markers, and ICTP obviously exceeded the reference value as compared with other bone resorption markers.</abstract><cop>Japan</cop><pub>Elsevier B.V</pub><pmid>17530373</pmid><doi>10.1007/s00776-007-1113-6</doi><tpages>8</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Amino Acids - urine Biomarkers - blood Biomarkers - urine Bone Neoplasms - complications Bone Neoplasms - metabolism Bone Neoplasms - secondary Bone Resorption - complications Bone Resorption - metabolism Collagen Type I - urine Female Femoral Fractures - etiology Femoral Fractures - metabolism Fractures, Spontaneous - etiology Fractures, Spontaneous - metabolism Humans Male Middle Aged Osteoporosis, Postmenopausal - complications Osteoporosis, Postmenopausal - metabolism Pelvic Bones - injuries Peptide Fragments - blood Peptides - urine Procollagen - blood Radioimmunoassay Severity of Illness Index |
| title | Change of cross-linked telopeptide of type I collagen (ICTP) and other bone resorption markers in patients with bone fragility fractures |
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