Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation

Angiotensin II (Ang II)-mediated signals are transmitted via heparin binding epidermal growth factor (EGF)-like growth factor (HB-EGF) release followed by transactivation of EGF receptor (EGFR). Although Ang II and HB-EGF induce angiogenesis, their link to the angiopoietin (Ang)-Tie2 system remains...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Circulation research 2001-01, Vol.88 (1), p.22
Hauptverfasser:	Fujiyama, S, Matsubara, H, Nozawa, Y, Maruyama, K, Mori, Y, Tsutsumi, Y, Masaki, H, Uchiyama, Y, Koyama, Y, Nose, A, Iba, O, Tateishi, E, Ogata, N, Jyo, N, Higashiyama, S, Iwasaka, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoietin-1 Angiopoietin-2 Angiotensin II - pharmacology Angiotensin Receptor Antagonists Animals Calcium - metabolism Cells, Cultured Cornea - blood supply Cornea - drug effects Endothelial Growth Factors - genetics Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Enzyme Activation - drug effects Epidermal Growth Factor - physiology ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics ErbB Receptors - metabolism Gene Expression Regulation - drug effects Heparin-binding EGF-like Growth Factor Imidazoles - pharmacology In Vitro Techniques Indoles - pharmacology Intercellular Signaling Peptides and Proteins Lymphokines - genetics Maleimides - pharmacology Membrane Glycoproteins - genetics Naphthalenes - pharmacology Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - physiology Olmesartan Medoxomil Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatases - metabolism Proteins - genetics Pyridines - pharmacology Quinazolines Rabbits Rats Receptor Protein-Tyrosine Kinases - genetics Receptor, Angiotensin, Type 1 Receptor, Angiotensin, Type 2 Receptor, TIE-2 Receptors, Angiotensin - physiology Receptors, Cell Surface Receptors, TIE RNA Stability - drug effects RNA, Messenger - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Tetrazoles - pharmacology Time Factors Transcriptional Activation Tyrphostins - pharmacology Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!