Regulation of Hepatic Insig-2 by the Farnesoid X Receptor

Activation of the farnesoid X receptor (FXRα) affects genes controlling many pathways, including those involved in bile acid and glucose homeostasis. Here we report that a critical gene involved in cholesterol homeostasis, Insig-2, was induced when mice or cultured cells were treated with FXRα agoni...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2007-06, Vol.21 (6), p.1359-1369
Hauptverfasser:	Hubbert, Melissa L, Zhang, Yanqiao, Lee, Florence Y, Edwards, Peter A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cholesterol - genetics Cholesterol - metabolism Chromatin Immunoprecipitation Cytochrome P-450 Enzyme System - genetics DNA-Binding Proteins - agonists DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Electrophoretic Mobility Shift Assay Gene Expression Regulation Genes, Reporter Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent - metabolism Liver - metabolism Membrane Proteins - genetics Mice Mice, Mutant Strains Oxidoreductases - genetics Receptors, Cytoplasmic and Nuclear - agonists Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Regulatory Elements, Transcriptional RNA, Messenger - analysis RNA, Messenger - metabolism Sterol 14-Demethylase Transcription Factors - agonists Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation
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