Methylselenol generated from selenomethionine by methioninase downregulates integrin expression and induces caspase-mediated apoptosis of B16F10 melanoma cells

Melanoma is a highly metastatic cancer resistant to current chemotherapeutic and radiotherapeutic approaches. Several studies have shown that interactions between cancer cells and the extracellular matrix (ECM) are critical for the survival and invasion of metastatic cancer cells. In this study, we...

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Veröffentlicht in:	Journal of cellular physiology 2007-08, Vol.212 (2), p.386-400
Hauptverfasser:	Kim, Aeyung, Oh, Jang-Hee, Park, Jong-Min, Chung, An-Sik
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Apoptosis - drug effects Carbon-Sulfur Lyases - metabolism Carbon-Sulfur Lyases - pharmacology Caspase Inhibitors Caspases - metabolism Cell Adhesion Cell Cycle Cell Proliferation Cell Shape Cell Survival Dose-Response Relationship, Drug Down-Regulation Enzyme Inhibitors - pharmacology Extracellular Matrix - metabolism Focal Adhesion Kinase 1 - metabolism I-kappa B Proteins - metabolism Integrins - metabolism Melanoma, Experimental - enzymology Melanoma, Experimental - metabolism Melanoma, Experimental - pathology Methanol - analogs & derivatives Mice Organometallic Compounds - metabolism Organoselenium Compounds p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Protein Kinase C-delta - antagonists & inhibitors Protein Kinase C-delta - metabolism Proto-Oncogene Proteins c-akt - metabolism Selenomethionine - metabolism Selenomethionine - pharmacology Signal Transduction Skin Neoplasms - enzymology Skin Neoplasms - metabolism Skin Neoplasms - pathology Sodium Selenite - pharmacology
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