Bilobalide prevents reduction of γ-aminobutyric acid levels and glutamic acid decarboxylase activity induced by 4-O-methylpyridoxine in mouse hippocampus

We previously reported that bilobalide, a constituent of Ginkgo biloba L. leaves, protected mice against convulsions induced by 4-O-methylpyridoxine (MPN). To elucidate the mechanism of the anticonvulsant activity of bilobalide, this study examined the effect of bilobalide on MPN-induced changes in...

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Veröffentlicht in:	Life sciences (1973) 2000-06, Vol.67 (6), p.709-715
Hauptverfasser:	Sasaki, Keiko, Hatta, Shinichi, Wada, Keiji, Ohshika, Hideyo, Haga, Masanobu
Format:	Artikel
Sprache:	eng
Schlagworte:	4-O-methylpyridoxine Animals Bilobalide Cerebral Cortex - drug effects Cerebral Cortex - enzymology Cerebral Cortex - metabolism Cyclopentanes - pharmacology Diterpenes Furans - pharmacology gamma-Aminobutyric Acid - metabolism Ginkgo biloba Ginkgo biloba - chemistry Ginkgolides Glutamate decarboxylase (GAD) Glutamate Decarboxylase - metabolism Glutamic Acid - metabolism Hippocampus - drug effects Hippocampus - enzymology Hippocampus - metabolism Male Mice Neostriatum - drug effects Neostriatum - enzymology Neostriatum - metabolism Nerve Tissue Proteins - metabolism Pyridoxine - analogs & derivatives Pyridoxine - antagonists & inhibitors Pyridoxine - pharmacology γ-Aminobutyric acid (GABA)
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