The role of microRNA in the delayed negative feedback regulation of gene expression

Oscillatory gene expression plays an important role in somite segmentation during the early developmental stages of vertebrates. Recent experimental studies have shown that microRNA can regulate gene expression by stimulating degradation of mRNA and/or repression of translation. In this communicatio...

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Veröffentlicht in:Biochemical and biophysical research communications 2007-07, Vol.358 (3), p.722-726
Hauptverfasser: Xie, Zhong-Ru, Yang, Hsih-Te, Liu, Wei-Chung, Hwang, Ming-Jing
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container_title Biochemical and biophysical research communications
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creator Xie, Zhong-Ru
Yang, Hsih-Te
Liu, Wei-Chung
Hwang, Ming-Jing
description Oscillatory gene expression plays an important role in somite segmentation during the early developmental stages of vertebrates. Recent experimental studies have shown that microRNA can regulate gene expression by stimulating degradation of mRNA and/or repression of translation. In this communication, we incorporate miRNA into a previous mathematical model of gene expression with delayed negative feedback and demonstrate how this modified model can elucidate the possible effect of miRNA on the oscillatory gene expression. Our finding suggests that miRNA maybe a destabilizing or stabilizing factor in the dynamics of gene expression depending on the severity of its effect on mRNA degradation. Our finding provides testable hypothesis for experimental biologists to further investigate miRNA’s increasing functional roles in regulating cellular processes and development.
doi_str_mv 10.1016/j.bbrc.2007.04.207
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subjects Animals
Basic Helix-Loop-Helix Transcription Factors - genetics
Basic Helix-Loop-Helix Transcription Factors - physiology
Feedback, Physiological
Gene Expression
Gene Expression Profiling
Gene Expression Regulation
Genes
Hes7
Mathematical model
Mice
MicroRNA
MicroRNAs - analysis
Models, Statistical
Models, Theoretical
Oscillation
Oscillometry
RNA, Messenger - metabolism
Time Factors
title The role of microRNA in the delayed negative feedback regulation of gene expression
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