Prevalence and genetic diversity of HIV type 1 subtypes A and D in women attending antenatal clinics in Uganda

To monitor the relative prevalence and evolutionary trends of HIV-1 in Uganda, we conducted a retrospective study of pregnant women over the time period 1989-2000. From a total of 300 women sampled, we defined subtypes by heteroduplex mobility assay for 230 subjects and by partial sequencing and phy...

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Veröffentlicht in:AIDS research and human retroviruses 2007-05, Vol.23 (5), p.755-760
Hauptverfasser: HERBECK, Joshua T, LYAGOBA, Frederick, MOORE, Sarah W, SHINDO, Nice, BIRYAHWAHO, Benon, KALEEBU, Pontiano, MULLINS, James I
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container_issue 5
container_start_page 755
container_title AIDS research and human retroviruses
container_volume 23
creator HERBECK, Joshua T
LYAGOBA, Frederick
MOORE, Sarah W
SHINDO, Nice
BIRYAHWAHO, Benon
KALEEBU, Pontiano
MULLINS, James I
description To monitor the relative prevalence and evolutionary trends of HIV-1 in Uganda, we conducted a retrospective study of pregnant women over the time period 1989-2000. From a total of 300 women sampled, we defined subtypes by heteroduplex mobility assay for 230 subjects and by partial sequencing and phylogenetic analyses of the env gene for 216 subjects. Subtypes A and D were most prevalent, and there were no significant trends in relative frequencies of subtypes A (45%), D (41%), C (5%), or recombinants (9%) over the 11 years sampled. There was also no phylogenetic clustering of subtypes related to geography (clinic location) or year of collection. Mean pairwise nucleotide diversity of subtype A (pi = 0.163) and subtype D (pi =0.156) samples did not differ significantly between subtypes, nor did these levels change over the period of the study. This report suggests that among pregnant women in Uganda A and D subtypes are transmitted without geographic constraints, and are not associated with significantly different transmission rates.
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subjects AIDS/HIV
Biological and medical sciences
Distribution
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
Genes, env
Genetic aspects
Genetic Variation
Health aspects
Heteroduplex Analysis
HIV (Viruses)
HIV Infections - epidemiology
HIV Infections - virology
HIV-1 - classification
HIV-1 - genetics
Human viral diseases
Humans
Infectious diseases
Medical examination
Medical sciences
Microbiology
Miscellaneous
Molecular Sequence Data
Phylogeny
Pregnancy
Pregnancy Complications, Infectious - epidemiology
Pregnancy Complications, Infectious - virology
Pregnant women
Prevalence
Prevalence studies (Epidemiology)
Prevention
Retrospective Studies
Uganda - epidemiology
Viral diseases
Virology
title Prevalence and genetic diversity of HIV type 1 subtypes A and D in women attending antenatal clinics in Uganda
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