Metabolic effects of physical training in ovariectomized and hyperestrogenic rats
Département de Kinésiologie, Université de Montréal, Montreal, Quebec, Canada H3C 3J7; and Gunma University, School of Medicine, 3-39-22, Maebashi-Shi, Gunma 371-8511, Japan This study was undertaken to evaluate the effects of regular endurance-type exercise on glucose tolerance and glucose-stimulat...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2001-01, Vol.90 (1), p.235-241 |
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| creator | Latour, Martin G Shinoda, Motoo Lavoie, Jean-Marc |
| description | Département de Kinésiologie, Université de
Montréal, Montreal, Quebec, Canada H3C 3J7; and Gunma
University, School of Medicine, 3-39-22, Maebashi-Shi, Gunma 371-8511, Japan
This study was undertaken to evaluate the
effects of regular endurance-type exercise on glucose tolerance and
glucose-stimulated insulin response (GSIR) in ovariectomized (OVX) rats
with and without estrogen replacement. To do that, OVX Sprague-Dawley
rats were compared with an OVX estradiol-treated group (OVXE2) and a
sham-operated (Sham) group. Each of these groups was subdivided into a
sedentary and a treadmill-trained (8 wk) group. Intravenous glucose
tolerance tests (0.5 g/kg) were conducted in all rats 48 h after
the last training session. Plasma levels of 17 -estradiol and the
uterus weight were significantly ( P |
| doi_str_mv | 10.1152/jappl.2001.90.1.235 |
| format | Article |
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Montréal, Montreal, Quebec, Canada H3C 3J7; and Gunma
University, School of Medicine, 3-39-22, Maebashi-Shi, Gunma 371-8511, Japan
This study was undertaken to evaluate the
effects of regular endurance-type exercise on glucose tolerance and
glucose-stimulated insulin response (GSIR) in ovariectomized (OVX) rats
with and without estrogen replacement. To do that, OVX Sprague-Dawley
rats were compared with an OVX estradiol-treated group (OVXE2) and a
sham-operated (Sham) group. Each of these groups was subdivided into a
sedentary and a treadmill-trained (8 wk) group. Intravenous glucose
tolerance tests (0.5 g/kg) were conducted in all rats 48 h after
the last training session. Plasma levels of 17 -estradiol and the
uterus weight were significantly ( P < 0.05) lower in
OVX compared with results in Sham and significantly ( P < 0.01) higher in OVXE2 (hyperestrogenic) compared with results in
Sham. Body weights were significantly ( P < 0.01)
different among groups, in the following decreasing order: OVX, Sham,
and OVXE2. The average daily food intake was significantly
( P < 0.01) increased in OVX rats compared with Sham,
whereas estradiol treatment diminished this effect ( P < 0.01). Exercise training was found to alter none of the
above-mentioned variables in all three experimental conditions. Although the mean integrated area under the glucose and insulin curves
was not affected by OVX, training induced a significant ( P < 0.01) reduction in the mean integrated area under
the insulin curve in all three experimental conditions. It is concluded
that the positive effects of physical training on improving GSIR in OVX
and hyperestrogenic animals are similar to what has been found in Sham.
ovariectomy; insulin sensitivity; exercise; food intake; glucose
tolerance test]]></description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.2001.90.1.235</identifier><identifier>PMID: 11133915</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Animals ; Biological and medical sciences ; Blood Glucose - analysis ; Diet ; Eating - drug effects ; Effects ; Estradiol - blood ; Estradiol - pharmacology ; Estrogens - blood ; Exercise ; Female ; Females ; Glucose Tolerance Test ; Hormones. Endocrine system ; Insulin ; Insulin - blood ; Medical sciences ; Metabolism ; Ovariectomy ; Pharmacology. Drug treatments ; Physical Conditioning, Animal - physiology ; Rats ; Rats, Sprague-Dawley ; Rodents ; Uterus - anatomy & histology</subject><ispartof>Journal of applied physiology (1985), 2001-01, Vol.90 (1), p.235-241</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright American Physiological Society Jan 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-d89da1ca585deb4b33e656202a1a7e58cbf98f9c45a5f2f6c5aea0a0139d22953</citedby><cites>FETCH-LOGICAL-c529t-d89da1ca585deb4b33e656202a1a7e58cbf98f9c45a5f2f6c5aea0a0139d22953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=959501$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11133915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Latour, Martin G</creatorcontrib><creatorcontrib>Shinoda, Motoo</creatorcontrib><creatorcontrib>Lavoie, Jean-Marc</creatorcontrib><title>Metabolic effects of physical training in ovariectomized and hyperestrogenic rats</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description><![CDATA[Département de Kinésiologie, Université de
Montréal, Montreal, Quebec, Canada H3C 3J7; and Gunma
University, School of Medicine, 3-39-22, Maebashi-Shi, Gunma 371-8511, Japan
This study was undertaken to evaluate the
effects of regular endurance-type exercise on glucose tolerance and
glucose-stimulated insulin response (GSIR) in ovariectomized (OVX) rats
with and without estrogen replacement. To do that, OVX Sprague-Dawley
rats were compared with an OVX estradiol-treated group (OVXE2) and a
sham-operated (Sham) group. Each of these groups was subdivided into a
sedentary and a treadmill-trained (8 wk) group. Intravenous glucose
tolerance tests (0.5 g/kg) were conducted in all rats 48 h after
the last training session. Plasma levels of 17 -estradiol and the
uterus weight were significantly ( P < 0.05) lower in
OVX compared with results in Sham and significantly ( P < 0.01) higher in OVXE2 (hyperestrogenic) compared with results in
Sham. Body weights were significantly ( P < 0.01)
different among groups, in the following decreasing order: OVX, Sham,
and OVXE2. The average daily food intake was significantly
( P < 0.01) increased in OVX rats compared with Sham,
whereas estradiol treatment diminished this effect ( P < 0.01). Exercise training was found to alter none of the
above-mentioned variables in all three experimental conditions. Although the mean integrated area under the glucose and insulin curves
was not affected by OVX, training induced a significant ( P < 0.01) reduction in the mean integrated area under
the insulin curve in all three experimental conditions. It is concluded
that the positive effects of physical training on improving GSIR in OVX
and hyperestrogenic animals are similar to what has been found in Sham.
ovariectomy; insulin sensitivity; exercise; food intake; glucose
tolerance test]]></description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Diet</subject><subject>Eating - drug effects</subject><subject>Effects</subject><subject>Estradiol - blood</subject><subject>Estradiol - pharmacology</subject><subject>Estrogens - blood</subject><subject>Exercise</subject><subject>Female</subject><subject>Females</subject><subject>Glucose Tolerance Test</subject><subject>Hormones. Endocrine system</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Ovariectomy</subject><subject>Pharmacology. Drug treatments</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Uterus - anatomy & histology</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdFrFDEQxoMo9qz-BYIsCvq0Zya7s7t5LKXVQosI9TnMZpO7HHubNdlVr3-9ufZqRZDmJTD5fTNf5mPsNfAlAIqPGxrHfik4h6VMpaUo8AlbpBeRQ8XhKVs0NfK8xqY-Yi9i3CSyLBGesyMAKAoJuGBfr8xEre-dzoy1Rk8x8zYb17voNPXZFMgNblhlbsj8DwouEX7rbkyX0dBl691ogolT8CszpBaBpviSPbPUR_PqcB-zb-dn16ef88svny5OTy5zjUJOedfIjkATNtiZtmyLwlRYCS4IqDbY6NbKxkpdIqEVttJIhjhxKGQnhMTimL2_6zsG_31OJtTWRW36ngbj56hqjgg1yEdBaNJaoCwS-PYfcOPnMKRPKJEOF3UFCSruIB18jMFYNQa3pbBTwNU-F3Wbi9rnomQqqZRLUr05tJ7brekeNIcgEvDuAFBMi7eBBu3iH06iRP7X8LVbrX-6YNRtUr73q506n_v-2vya9gbuB6uxs0n14f-qBD_Y_A0uhLfP</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>Latour, Martin G</creator><creator>Shinoda, Motoo</creator><creator>Lavoie, Jean-Marc</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20010101</creationdate><title>Metabolic effects of physical training in ovariectomized and hyperestrogenic rats</title><author>Latour, Martin G ; Shinoda, Motoo ; Lavoie, Jean-Marc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-d89da1ca585deb4b33e656202a1a7e58cbf98f9c45a5f2f6c5aea0a0139d22953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Diet</topic><topic>Eating - drug effects</topic><topic>Effects</topic><topic>Estradiol - blood</topic><topic>Estradiol - pharmacology</topic><topic>Estrogens - blood</topic><topic>Exercise</topic><topic>Female</topic><topic>Females</topic><topic>Glucose Tolerance Test</topic><topic>Hormones. Endocrine system</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Ovariectomy</topic><topic>Pharmacology. Drug treatments</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Uterus - anatomy & histology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Latour, Martin G</creatorcontrib><creatorcontrib>Shinoda, Motoo</creatorcontrib><creatorcontrib>Lavoie, Jean-Marc</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Latour, Martin G</au><au>Shinoda, Motoo</au><au>Lavoie, Jean-Marc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic effects of physical training in ovariectomized and hyperestrogenic rats</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2001-01-01</date><risdate>2001</risdate><volume>90</volume><issue>1</issue><spage>235</spage><epage>241</epage><pages>235-241</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract><![CDATA[Département de Kinésiologie, Université de
Montréal, Montreal, Quebec, Canada H3C 3J7; and Gunma
University, School of Medicine, 3-39-22, Maebashi-Shi, Gunma 371-8511, Japan
This study was undertaken to evaluate the
effects of regular endurance-type exercise on glucose tolerance and
glucose-stimulated insulin response (GSIR) in ovariectomized (OVX) rats
with and without estrogen replacement. To do that, OVX Sprague-Dawley
rats were compared with an OVX estradiol-treated group (OVXE2) and a
sham-operated (Sham) group. Each of these groups was subdivided into a
sedentary and a treadmill-trained (8 wk) group. Intravenous glucose
tolerance tests (0.5 g/kg) were conducted in all rats 48 h after
the last training session. Plasma levels of 17 -estradiol and the
uterus weight were significantly ( P < 0.05) lower in
OVX compared with results in Sham and significantly ( P < 0.01) higher in OVXE2 (hyperestrogenic) compared with results in
Sham. Body weights were significantly ( P < 0.01)
different among groups, in the following decreasing order: OVX, Sham,
and OVXE2. The average daily food intake was significantly
( P < 0.01) increased in OVX rats compared with Sham,
whereas estradiol treatment diminished this effect ( P < 0.01). Exercise training was found to alter none of the
above-mentioned variables in all three experimental conditions. Although the mean integrated area under the glucose and insulin curves
was not affected by OVX, training induced a significant ( P < 0.01) reduction in the mean integrated area under
the insulin curve in all three experimental conditions. It is concluded
that the positive effects of physical training on improving GSIR in OVX
and hyperestrogenic animals are similar to what has been found in Sham.
ovariectomy; insulin sensitivity; exercise; food intake; glucose
tolerance test]]></abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>11133915</pmid><doi>10.1152/jappl.2001.90.1.235</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of applied physiology (1985), 2001-01, Vol.90 (1), p.235-241 |
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| language | eng |
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| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Blood Glucose - analysis Diet Eating - drug effects Effects Estradiol - blood Estradiol - pharmacology Estrogens - blood Exercise Female Females Glucose Tolerance Test Hormones. Endocrine system Insulin Insulin - blood Medical sciences Metabolism Ovariectomy Pharmacology. Drug treatments Physical Conditioning, Animal - physiology Rats Rats, Sprague-Dawley Rodents Uterus - anatomy & histology |
| title | Metabolic effects of physical training in ovariectomized and hyperestrogenic rats |
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