Facile synthetic route to enantiopure unsymmetric cis-2,5-disubstituted pyrrolidines

The (+/−)‐cis‐5‐arylcarbamoyl‐2‐ethoxycarbonylpyrrolidines 6a–g were firstly synthesized in 53–64% yields by using meso‐diethyl‐2,5‐dibromoadipate 3 and (S)‐(−)‐1‐phenylethylamine in three steps. The diastereomeric mixture (S;2S,5R)‐(−)‐7 and (S;2R,5S)‐(+)‐8 were prepared by the Grignard reaction an...

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