Urine GABA levels in ovarian cancer patients:: elevated GABA in malignancy
The association of malignancy with elevated diamine oxidase (DAO), an enzyme producing gamma-aminobutyric acid (GABA) is well documented. In ovarian cancer, increased DAO occurs in the malignant tissues and plasma. Since higher DAO levels cause GABA accumulation, elevated GABA may occur in ovarian c...
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| Veröffentlicht in: | Cancer letters 2001-01, Vol.162 (1), p.27-30 |
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| container_title | Cancer letters |
| container_volume | 162 |
| creator | Nicholson-Guthrie, Catherine S. Guthrie, George D. Sutton, Gregory P. Baenziger, John C. |
| description | The association of malignancy with elevated diamine oxidase (DAO), an enzyme producing gamma-aminobutyric acid (GABA) is well documented. In ovarian cancer, increased DAO occurs in the malignant tissues and plasma. Since higher DAO levels cause GABA accumulation, elevated GABA may occur in ovarian cancer and be reflected in urine. We tested this hypothesis and found that half the ovarian cancer patients had a clearly elevated urine GABA, a result that is in agreement with previous reports on DAO and malignancy. The published findings on DAO, GABA and malignancy suggest that elevated GABA is associated with cancer. This proposal could lead to a GABA urine monitor or new directions in cancer treatment or research. |
| doi_str_mv | 10.1016/S0304-3835(00)00620-0 |
| format | Article |
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Obstetrics</subject><subject>Humans</subject><subject>Malignancy</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - urine</subject><subject>Pilot Projects</subject><subject>Tumors</subject><subject>Urine GABA</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90U1LAzEQBuAgiq3Vn6AsCKKH1ckm2U17kVq0KgUP2nPIJrMS2W5rsi3035t-2NNcnhmY9yXkksI9BZo_fAIDnjLJxC3AHUCeQQpHpEtlkaVFX8Ix6R5Ih5yF8AMAghfilHQopRmVot8l71PvGkzGw6dhUuMK65C4JpmvtHe6SYxuDPpkoVuHTRsGgwQj0i3a3UakM1277ya69Tk5qXQd8GI_e2T68vw1ek0nH-O30XCSGsZZm2IlcluVBbOSl7qECmRZgmQUC54LKWhpuWVcihylzowWGo1FbiqaG9MXmvXIze7uws9_lxhaNXPBYF3rBufLoAoQAjIhIrzaw2U5Q6sW3s20X6v_7yO43gMdjK4rH99w4eCk4LKQUT3uVAwHVw69CibGYdA6j6ZVdu4UBbVpRW1bUZvIFYDatqKA_QFEiXyz</recordid><startdate>20010110</startdate><enddate>20010110</enddate><creator>Nicholson-Guthrie, Catherine S.</creator><creator>Guthrie, George D.</creator><creator>Sutton, Gregory P.</creator><creator>Baenziger, John C.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20010110</creationdate><title>Urine GABA levels in ovarian cancer patients:: elevated GABA in malignancy</title><author>Nicholson-Guthrie, Catherine S. ; Guthrie, George D. ; Sutton, Gregory P. ; Baenziger, John C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-ef56dfb73d84bab0f08bb0831e7465851bd4d34856e8a2ca5aecde4cf16cc95a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Amine Oxidase (Copper-Containing) - metabolism</topic><topic>Biological and medical sciences</topic><topic>Diamine oxidase</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gamma-aminobutyric acid</topic><topic>gamma-Aminobutyric Acid - urine</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Malignancy</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ovarian cancer</topic><topic>Ovarian Neoplasms - urine</topic><topic>Pilot Projects</topic><topic>Tumors</topic><topic>Urine GABA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nicholson-Guthrie, Catherine S.</creatorcontrib><creatorcontrib>Guthrie, George D.</creatorcontrib><creatorcontrib>Sutton, Gregory P.</creatorcontrib><creatorcontrib>Baenziger, John C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nicholson-Guthrie, Catherine S.</au><au>Guthrie, George D.</au><au>Sutton, Gregory P.</au><au>Baenziger, John C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urine GABA levels in ovarian cancer patients:: elevated GABA in malignancy</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2001-01-10</date><risdate>2001</risdate><volume>162</volume><issue>1</issue><spage>27</spage><epage>30</epage><pages>27-30</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>The association of malignancy with elevated diamine oxidase (DAO), an enzyme producing gamma-aminobutyric acid (GABA) is well documented. 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| ispartof | Cancer letters, 2001-01, Vol.162 (1), p.27-30 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Aged Amine Oxidase (Copper-Containing) - metabolism Biological and medical sciences Diamine oxidase Female Female genital diseases Gamma-aminobutyric acid gamma-Aminobutyric Acid - urine Gynecology. Andrology. Obstetrics Humans Malignancy Medical sciences Middle Aged Ovarian cancer Ovarian Neoplasms - urine Pilot Projects Tumors Urine GABA |
| title | Urine GABA levels in ovarian cancer patients:: elevated GABA in malignancy |
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