Hypocretin (orexin) loss in Parkinson's disease

The hypothalamic hypocretin (orexin) system plays a central role in the regulation of various functions, including sleep/wake regulation and metabolism. There is a growing interest in hypocretin function in Parkinson's disease (PD), given the high prevalence of non-motor symptoms such as sleep...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2007-06, Vol.130 (6), p.1577-1585
Hauptverfasser:	Fronczek, Rolf, Overeem, Sebastiaan, Lee, Sandy Y. Y., Hegeman, Ingrid. M., van Pelt, Johannes, van Duinen, Sjoerd. G., Lammers, Gert Jan, Swaab, Dick F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biological and medical sciences Cell Count Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Hypothalamus - chemistry Hypothalamus - pathology Immunoenzyme Techniques Intracellular Signaling Peptides and Proteins - analysis Intracellular Signaling Peptides and Proteins - cerebrospinal fluid Intracellular Signaling Peptides and Proteins - deficiency Lewy Bodies - chemistry Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Neurons - chemistry Neuropeptides - analysis Neuropeptides - cerebrospinal fluid Neuropeptides - deficiency Orexins Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Prefrontal Cortex - chemistry
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