Ethnic variations in paraoxonase1 polymorphism in the malaysian population
The role of high-density lipoprotein associated paraoxonase (PON) 1 in protection against oxidative stress associated with the development of complications in diabetes mellitus has been reported. Variations in the PON1 gene, 55LM and 192QR have been described in different populations. These variatio...
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| Veröffentlicht in: | Southeast Asian journal of tropical medicine and public health 2007-03, Vol.38 (2), p.392-397 |
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| description | The role of high-density lipoprotein associated paraoxonase (PON) 1 in protection against oxidative stress associated with the development of complications in diabetes mellitus has been reported. Variations in the PON1 gene, 55LM and 192QR have been described in different populations. These variations are known to be risk factors for heart disease, especially the L and R alleles. We have investigated the prevalence of both polymorphisms in the Malaysian population comprising the three major ethnic groups: Malay, Chinese and Indian, using polymerase chain reaction followed by restriction endonuclease digestion. The results show the pooled frequencies of L and R alleles were 0.91 and 0.54, respectively, similar to those in the Asian region. The frequency of the M allele was higher in Indians (p < 0.05), whereas the R allele was higher in both the Chinese and Malays compared to Indians (p < 0.05), indicating ethnic group-dependent genetic differences. The most common genotypic combination was LL/QR, followed by LL/RR. The genotype frequencies for the total Malaysian population showed a significant departure from Hardy-Weinberg equilibrium for the 55LM (p = 0.013) but not the 192QR (p = 0.056) polymorphisms. A strong linkage disequilibrium between L/55 and R/192 alleles was also observed. In the Malaysian population as a whole, Malays and Chinese showed a higher frequency of the R allele which is a risk factor for cardiovascular diseases. |
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Variations in the PON1 gene, 55LM and 192QR have been described in different populations. These variations are known to be risk factors for heart disease, especially the L and R alleles. We have investigated the prevalence of both polymorphisms in the Malaysian population comprising the three major ethnic groups: Malay, Chinese and Indian, using polymerase chain reaction followed by restriction endonuclease digestion. The results show the pooled frequencies of L and R alleles were 0.91 and 0.54, respectively, similar to those in the Asian region. The frequency of the M allele was higher in Indians (p < 0.05), whereas the R allele was higher in both the Chinese and Malays compared to Indians (p < 0.05), indicating ethnic group-dependent genetic differences. The most common genotypic combination was LL/QR, followed by LL/RR. The genotype frequencies for the total Malaysian population showed a significant departure from Hardy-Weinberg equilibrium for the 55LM (p = 0.013) but not the 192QR (p = 0.056) polymorphisms. A strong linkage disequilibrium between L/55 and R/192 alleles was also observed. In the Malaysian population as a whole, Malays and Chinese showed a higher frequency of the R allele which is a risk factor for cardiovascular diseases.</description><identifier>ISSN: 0125-1562</identifier><identifier>PMID: 17539292</identifier><identifier>CODEN: SJTMAK</identifier><language>eng</language><publisher>Bangkok: Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Aryldialkylphosphatase - genetics ; Asian Continental Ancestry Group - genetics ; Biological and medical sciences ; Cardiovascular Diseases - ethnology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - genetics ; China - ethnology ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - ethnology ; Diabetes Mellitus, Type 2 - genetics ; DNA Primers ; Female ; Gene Frequency ; General aspects ; Genotype ; Humans ; India - ethnology ; Lipoproteins, HDL ; Malaysia ; Male ; Medical sciences ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Risk Factors</subject><ispartof>Southeast Asian journal of tropical medicine and public health, 2007-03, Vol.38 (2), p.392-397</ispartof><rights>2007 INIST-CNRS</rights><rights>Copyright Central Coordinating Board, SEAMEO-TROPMED Project Mar 2007</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18776252$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17539292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>POH, Rozaida</creatorcontrib><creatorcontrib>MUNIANDY, Sekaran</creatorcontrib><title>Ethnic variations in paraoxonase1 polymorphism in the malaysian population</title><title>Southeast Asian journal of tropical medicine and public health</title><addtitle>Southeast Asian J Trop Med Public Health</addtitle><description>The role of high-density lipoprotein associated paraoxonase (PON) 1 in protection against oxidative stress associated with the development of complications in diabetes mellitus has been reported. Variations in the PON1 gene, 55LM and 192QR have been described in different populations. These variations are known to be risk factors for heart disease, especially the L and R alleles. We have investigated the prevalence of both polymorphisms in the Malaysian population comprising the three major ethnic groups: Malay, Chinese and Indian, using polymerase chain reaction followed by restriction endonuclease digestion. The results show the pooled frequencies of L and R alleles were 0.91 and 0.54, respectively, similar to those in the Asian region. The frequency of the M allele was higher in Indians (p < 0.05), whereas the R allele was higher in both the Chinese and Malays compared to Indians (p < 0.05), indicating ethnic group-dependent genetic differences. The most common genotypic combination was LL/QR, followed by LL/RR. The genotype frequencies for the total Malaysian population showed a significant departure from Hardy-Weinberg equilibrium for the 55LM (p = 0.013) but not the 192QR (p = 0.056) polymorphisms. A strong linkage disequilibrium between L/55 and R/192 alleles was also observed. In the Malaysian population as a whole, Malays and Chinese showed a higher frequency of the R allele which is a risk factor for cardiovascular diseases.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Aryldialkylphosphatase - genetics</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular Diseases - ethnology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - genetics</subject><subject>China - ethnology</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - ethnology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>DNA Primers</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>General aspects</subject><subject>Genotype</subject><subject>Humans</subject><subject>India - ethnology</subject><subject>Lipoproteins, HDL</subject><subject>Malaysia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Risk Factors</subject><issn>0125-1562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpd0EFLwzAUB_AeFDenX0GKoLdCkiZpcpQxnTLwoufykr2wjLapSSvu21t1Inh6h_f7P_68k2xOKBMFFZLNsvOU9oRwQrU6y2a0EqVmms2zp9Ww67zN3yF6GHzoUu67vIcI4SN0kJDmfWgObYj9zqf2aznsMG-hgUPyMNHQj8138iI7ddAkvDzORfZ6v3pZrovN88Pj8m5T9FTRodCIXJHSWG2cpqCnUhYNMRVKo61QiA5Kw7ByVBspuTV6K7RTDp3cSk3KRXb7c7eP4W3ENNStTxabBjoMY6orIrjmXE_w-h_chzF2U7eaEcqlVJWa0NURjabFbd1H30I81L8vmsDNEUCy0LgInfXpz6mqkkyw8hOqqm-l</recordid><startdate>200703</startdate><enddate>200703</enddate><creator>POH, Rozaida</creator><creator>MUNIANDY, Sekaran</creator><general>Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network</general><general>Central Coordinating Board, SEAMEO-TROPMED Project</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BVBZV</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope><scope>7X8</scope></search><sort><creationdate>200703</creationdate><title>Ethnic variations in paraoxonase1 polymorphism in the malaysian population</title><author>POH, Rozaida ; MUNIANDY, Sekaran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p181t-9ee4803bc9bf91a9040ceb0b7e6b9c58eefa3b2e7f19b664cb9d59f8fef6d6903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>Aryldialkylphosphatase - genetics</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular Diseases - ethnology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - genetics</topic><topic>China - ethnology</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - ethnology</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>DNA Primers</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>General aspects</topic><topic>Genotype</topic><topic>Humans</topic><topic>India - ethnology</topic><topic>Lipoproteins, HDL</topic><topic>Malaysia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Risk Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>POH, Rozaida</creatorcontrib><creatorcontrib>MUNIANDY, Sekaran</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East & South Asia Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environmental Science Collection</collection><collection>MEDLINE - Academic</collection><jtitle>Southeast Asian journal of tropical medicine and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>POH, Rozaida</au><au>MUNIANDY, Sekaran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethnic variations in paraoxonase1 polymorphism in the malaysian population</atitle><jtitle>Southeast Asian journal of tropical medicine and public health</jtitle><addtitle>Southeast Asian J Trop Med Public Health</addtitle><date>2007-03</date><risdate>2007</risdate><volume>38</volume><issue>2</issue><spage>392</spage><epage>397</epage><pages>392-397</pages><issn>0125-1562</issn><coden>SJTMAK</coden><abstract>The role of high-density lipoprotein associated paraoxonase (PON) 1 in protection against oxidative stress associated with the development of complications in diabetes mellitus has been reported. Variations in the PON1 gene, 55LM and 192QR have been described in different populations. These variations are known to be risk factors for heart disease, especially the L and R alleles. We have investigated the prevalence of both polymorphisms in the Malaysian population comprising the three major ethnic groups: Malay, Chinese and Indian, using polymerase chain reaction followed by restriction endonuclease digestion. The results show the pooled frequencies of L and R alleles were 0.91 and 0.54, respectively, similar to those in the Asian region. The frequency of the M allele was higher in Indians (p < 0.05), whereas the R allele was higher in both the Chinese and Malays compared to Indians (p < 0.05), indicating ethnic group-dependent genetic differences. The most common genotypic combination was LL/QR, followed by LL/RR. The genotype frequencies for the total Malaysian population showed a significant departure from Hardy-Weinberg equilibrium for the 55LM (p = 0.013) but not the 192QR (p = 0.056) polymorphisms. A strong linkage disequilibrium between L/55 and R/192 alleles was also observed. In the Malaysian population as a whole, Malays and Chinese showed a higher frequency of the R allele which is a risk factor for cardiovascular diseases.</abstract><cop>Bangkok</cop><pub>Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network</pub><pmid>17539292</pmid><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Analysis of Variance Aryldialkylphosphatase - genetics Asian Continental Ancestry Group - genetics Biological and medical sciences Cardiovascular Diseases - ethnology Cardiovascular Diseases - etiology Cardiovascular Diseases - genetics China - ethnology Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - genetics DNA Primers Female Gene Frequency General aspects Genotype Humans India - ethnology Lipoproteins, HDL Malaysia Male Medical sciences Middle Aged Polymerase Chain Reaction Polymorphism, Genetic Risk Factors |
| title | Ethnic variations in paraoxonase1 polymorphism in the malaysian population |
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