Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia

The Flt3 gene encodes a tyrosine kinase receptor that regulates proliferation and differentiation of hematopoietic stem cells. An internal tandem duplication of the Flt3 gene (Flt3/ITD) has been reported in acute myelogenous leukemia (AML) and may be associated with poor prognosis. We analyzed diagn...

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Veröffentlicht in:	Blood 2001-01, Vol.97 (1), p.89-94
Hauptverfasser:	Meshinchi, Soheil, Woods, William G., Stirewalt, Derek L., Sweetser, David A., Buckley, Jonathan D., Tjoa, Thomas K., Bernstein, Irwin D., Radich, Jerald P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adolescent Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Bone Marrow Cell Lineage Child Child, Preschool fms-Like Tyrosine Kinase 3 Genetic Testing Hematologic and hematopoietic diseases Humans Leukemia, Myeloid - diagnosis Leukemia, Myeloid - drug therapy Leukemia, Myeloid - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocyte Count Lymphocytes - cytology Medical sciences Polymerase Chain Reaction Prevalence Prognosis Proto-Oncogene Proteins - genetics Receptor Protein-Tyrosine Kinases - genetics Sequence Analysis, DNA Stem Cells - cytology Tandem Repeat Sequences - genetics Treatment Outcome
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