RANTES Potentiates Antigen-Specific Mucosal Immune Responses

RANTES is produced by lymphoid and epithelial cells of the mucosa in response to various external stimuli and is chemotactic for lymphocytes. The role of RANTES in adaptive mucosal immunity has not been studied. To better elucidate the role of this chemokine, we have characterized the effects of RAN...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-01, Vol.166 (1), p.162-169
Hauptverfasser:	Lillard, James W., Jr, Boyaka, Prosper N, Taub, Dennis D, McGhee, Jerry R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - physiology Administration, Intranasal Animals Antibody-Producing Cells - immunology Antibody-Producing Cells - metabolism B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - metabolism CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Chemokine CCL5 - administration & dosage Chemokine CCL5 - physiology Cytokines - biosynthesis Epitopes - administration & dosage Epitopes - immunology Epitopes, T-Lymphocyte - immunology Female Immunity, Mucosal - immunology Immunoglobulin A - biosynthesis Immunoglobulin G - biosynthesis Immunoglobulin G - blood Immunoglobulin M - biosynthesis Immunoglobulin M - blood Interleukin-12 Interphase - immunology Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Lymphocyte Activation Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic Nasal Mucosa - immunology Nasal Mucosa - metabolism Ovalbumin - administration & dosage Ovalbumin - immunology RANTES Receptors, Interleukin - biosynthesis Receptors, Interleukin-12 T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism
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