Gender and autoimmunity
Abstract The enhanced immunoreactivity in females is a double-edged sword that provides better protection against infections, but may lead to enhanced autoreactivity and thereby contribute to the induction of autoimmunity. Autoimmune diseases demonstrate a gender bias and represent the fifth leading...
Gespeichert in:
| Veröffentlicht in: | Autoimmunity reviews 2007-06, Vol.6 (6), p.366-372 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 372 |
|---|---|
| container_issue | 6 |
| container_start_page | 366 |
| container_title | Autoimmunity reviews |
| container_volume | 6 |
| creator | Zandman-Goddard, Gisele Peeva, Elena Shoenfeld, Yehuda |
| description | Abstract The enhanced immunoreactivity in females is a double-edged sword that provides better protection against infections, but may lead to enhanced autoreactivity and thereby contribute to the induction of autoimmunity. Autoimmune diseases demonstrate a gender bias and represent the fifth leading cause of death by disease among females of reproductive age. Clinical and murine experimental studies indicate that the gender bias in autoimmunity may be influenced by sex hormones, predominantly displayed in the development and exacerbations of the prototypical autoimmune disease lupus. The associations between sex hormones and other autoimmune diseases are less clear. Our review on the impact of gender via sex hormones and sex related genes in the pathogenesis of several autoimmune diseases suggests that a better understanding of the underlying mechanisms behind the sexual dimorphism of the immune system may lead to the development of novel therapeutic approaches to autoimmunity. |
| doi_str_mv | 10.1016/j.autrev.2006.10.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70544854</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1568997206001716</els_id><sourcerecordid>19885741</sourcerecordid><originalsourceid>FETCH-LOGICAL-c446t-69d62361a533934fe9e28b883924be88a12a83f9c4e406a81b89596ee024205b3</originalsourceid><addsrcrecordid>eNqFkUtLAzEURoMotlbXbkS6ctcxr8kkG0GKVqHgQl2HTOYOpM6jJjOF_nszTEFx01Uul_N9gXMRuiE4IZiI-01i-s7DLqEYi7hKMCYnaEpSIRdKZfT0zzxBFyFsIiAUVedoQrKUZUzSKbpeQVOAn5ummMe-1tV137huf4nOSlMFuDq8M_T5_PSxfFms31avy8f1wnIuuoVQhaBMEJMyphgvQQGVuZRMUZ6DlIZQI1mpLAeOhZEklypVAgBTTnGasxm6G3u3vv3uIXS6dsFCVZkG2j7oDKecy5QfBYmSMs04iSAfQevbEDyUeutdbfxeE6wHc3qjR3N6MDdso5gYuz3093kNxW_ooCoCDyMAUcfOgdfBOmgsFM6D7XTRumM__C-wlWucNdUX7CFs2t43UbUmOlCN9ftwveF4WMR0RgT7AYaAkvo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19885741</pqid></control><display><type>article</type><title>Gender and autoimmunity</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Zandman-Goddard, Gisele ; Peeva, Elena ; Shoenfeld, Yehuda</creator><creatorcontrib>Zandman-Goddard, Gisele ; Peeva, Elena ; Shoenfeld, Yehuda</creatorcontrib><description>Abstract The enhanced immunoreactivity in females is a double-edged sword that provides better protection against infections, but may lead to enhanced autoreactivity and thereby contribute to the induction of autoimmunity. Autoimmune diseases demonstrate a gender bias and represent the fifth leading cause of death by disease among females of reproductive age. Clinical and murine experimental studies indicate that the gender bias in autoimmunity may be influenced by sex hormones, predominantly displayed in the development and exacerbations of the prototypical autoimmune disease lupus. The associations between sex hormones and other autoimmune diseases are less clear. Our review on the impact of gender via sex hormones and sex related genes in the pathogenesis of several autoimmune diseases suggests that a better understanding of the underlying mechanisms behind the sexual dimorphism of the immune system may lead to the development of novel therapeutic approaches to autoimmunity.</description><identifier>ISSN: 1568-9972</identifier><identifier>EISSN: 1568-9972</identifier><identifier>DOI: 10.1016/j.autrev.2006.10.001</identifier><identifier>PMID: 17537382</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Allergy and Immunology ; Animals ; Autoimmune Diseases - immunology ; Autoimmune Diseases - metabolism ; Autoimmune Diseases - physiopathology ; Estrogen ; Female ; Gender ; Gonadal Steroid Hormones - metabolism ; Humans ; Male ; Prolactin ; Rheumatoid arthritis ; Sex Characteristics ; SLE ; Systemic sclerosis</subject><ispartof>Autoimmunity reviews, 2007-06, Vol.6 (6), p.366-372</ispartof><rights>Elsevier B.V.</rights><rights>2006 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-69d62361a533934fe9e28b883924be88a12a83f9c4e406a81b89596ee024205b3</citedby><cites>FETCH-LOGICAL-c446t-69d62361a533934fe9e28b883924be88a12a83f9c4e406a81b89596ee024205b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.autrev.2006.10.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17537382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zandman-Goddard, Gisele</creatorcontrib><creatorcontrib>Peeva, Elena</creatorcontrib><creatorcontrib>Shoenfeld, Yehuda</creatorcontrib><title>Gender and autoimmunity</title><title>Autoimmunity reviews</title><addtitle>Autoimmun Rev</addtitle><description>Abstract The enhanced immunoreactivity in females is a double-edged sword that provides better protection against infections, but may lead to enhanced autoreactivity and thereby contribute to the induction of autoimmunity. Autoimmune diseases demonstrate a gender bias and represent the fifth leading cause of death by disease among females of reproductive age. Clinical and murine experimental studies indicate that the gender bias in autoimmunity may be influenced by sex hormones, predominantly displayed in the development and exacerbations of the prototypical autoimmune disease lupus. The associations between sex hormones and other autoimmune diseases are less clear. Our review on the impact of gender via sex hormones and sex related genes in the pathogenesis of several autoimmune diseases suggests that a better understanding of the underlying mechanisms behind the sexual dimorphism of the immune system may lead to the development of novel therapeutic approaches to autoimmunity.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Autoimmune Diseases - immunology</subject><subject>Autoimmune Diseases - metabolism</subject><subject>Autoimmune Diseases - physiopathology</subject><subject>Estrogen</subject><subject>Female</subject><subject>Gender</subject><subject>Gonadal Steroid Hormones - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Prolactin</subject><subject>Rheumatoid arthritis</subject><subject>Sex Characteristics</subject><subject>SLE</subject><subject>Systemic sclerosis</subject><issn>1568-9972</issn><issn>1568-9972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLAzEURoMotlbXbkS6ctcxr8kkG0GKVqHgQl2HTOYOpM6jJjOF_nszTEFx01Uul_N9gXMRuiE4IZiI-01i-s7DLqEYi7hKMCYnaEpSIRdKZfT0zzxBFyFsIiAUVedoQrKUZUzSKbpeQVOAn5ummMe-1tV137huf4nOSlMFuDq8M_T5_PSxfFms31avy8f1wnIuuoVQhaBMEJMyphgvQQGVuZRMUZ6DlIZQI1mpLAeOhZEklypVAgBTTnGasxm6G3u3vv3uIXS6dsFCVZkG2j7oDKecy5QfBYmSMs04iSAfQevbEDyUeutdbfxeE6wHc3qjR3N6MDdso5gYuz3093kNxW_ooCoCDyMAUcfOgdfBOmgsFM6D7XTRumM__C-wlWucNdUX7CFs2t43UbUmOlCN9ftwveF4WMR0RgT7AYaAkvo</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Zandman-Goddard, Gisele</creator><creator>Peeva, Elena</creator><creator>Shoenfeld, Yehuda</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070601</creationdate><title>Gender and autoimmunity</title><author>Zandman-Goddard, Gisele ; Peeva, Elena ; Shoenfeld, Yehuda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-69d62361a533934fe9e28b883924be88a12a83f9c4e406a81b89596ee024205b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Autoimmune Diseases - immunology</topic><topic>Autoimmune Diseases - metabolism</topic><topic>Autoimmune Diseases - physiopathology</topic><topic>Estrogen</topic><topic>Female</topic><topic>Gender</topic><topic>Gonadal Steroid Hormones - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Prolactin</topic><topic>Rheumatoid arthritis</topic><topic>Sex Characteristics</topic><topic>SLE</topic><topic>Systemic sclerosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zandman-Goddard, Gisele</creatorcontrib><creatorcontrib>Peeva, Elena</creatorcontrib><creatorcontrib>Shoenfeld, Yehuda</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Autoimmunity reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zandman-Goddard, Gisele</au><au>Peeva, Elena</au><au>Shoenfeld, Yehuda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gender and autoimmunity</atitle><jtitle>Autoimmunity reviews</jtitle><addtitle>Autoimmun Rev</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>6</volume><issue>6</issue><spage>366</spage><epage>372</epage><pages>366-372</pages><issn>1568-9972</issn><eissn>1568-9972</eissn><abstract>Abstract The enhanced immunoreactivity in females is a double-edged sword that provides better protection against infections, but may lead to enhanced autoreactivity and thereby contribute to the induction of autoimmunity. Autoimmune diseases demonstrate a gender bias and represent the fifth leading cause of death by disease among females of reproductive age. Clinical and murine experimental studies indicate that the gender bias in autoimmunity may be influenced by sex hormones, predominantly displayed in the development and exacerbations of the prototypical autoimmune disease lupus. The associations between sex hormones and other autoimmune diseases are less clear. Our review on the impact of gender via sex hormones and sex related genes in the pathogenesis of several autoimmune diseases suggests that a better understanding of the underlying mechanisms behind the sexual dimorphism of the immune system may lead to the development of novel therapeutic approaches to autoimmunity.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>17537382</pmid><doi>10.1016/j.autrev.2006.10.001</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1568-9972 |
| ispartof | Autoimmunity reviews, 2007-06, Vol.6 (6), p.366-372 |
| issn | 1568-9972 1568-9972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70544854 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Allergy and Immunology Animals Autoimmune Diseases - immunology Autoimmune Diseases - metabolism Autoimmune Diseases - physiopathology Estrogen Female Gender Gonadal Steroid Hormones - metabolism Humans Male Prolactin Rheumatoid arthritis Sex Characteristics SLE Systemic sclerosis |
| title | Gender and autoimmunity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T08%3A54%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gender%20and%20autoimmunity&rft.jtitle=Autoimmunity%20reviews&rft.au=Zandman-Goddard,%20Gisele&rft.date=2007-06-01&rft.volume=6&rft.issue=6&rft.spage=366&rft.epage=372&rft.pages=366-372&rft.issn=1568-9972&rft.eissn=1568-9972&rft_id=info:doi/10.1016/j.autrev.2006.10.001&rft_dat=%3Cproquest_cross%3E19885741%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19885741&rft_id=info:pmid/17537382&rft_els_id=1_s2_0_S1568997206001716&rfr_iscdi=true |