Statins Activate Peroxisome Proliferator-Activated Receptor γ Through Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase–Dependent Cyclooxygenase-2 Expression in Macrophages

Both statins and peroxisome proliferator-activated receptor (PPAR)γ ligands have been reported to protect against the progression of atherosclerosis. In the present study, we investigated the effects of statins on PPARγ activation in macrophages. Statins increased PPARγ activity, which was inhibited...

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Veröffentlicht in:	Circulation research 2007-05, Vol.100 (10), p.1442-1451
Hauptverfasser:	Yano, Miyuki, Matsumura, Takeshi, Senokuchi, Takafumi, Ishii, Norio, Murata, Yusuke, Taketa, Kayo, Motoshima, Hiroyuki, Taguchi, Tetsuya, Sonoda, Kazuhiro, Kukidome, Daisuke, Takuwa, Yoh, Kawada, Teruo, Brownlee, Michael, Nishikawa, Takeshi, Araki, Eiichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters - genetics Biological and medical sciences CD36 Antigens - genetics cdc42 GTP-Binding Protein - antagonists & inhibitors Cells, Cultured Cyclooxygenase 2 - genetics Extracellular Signal-Regulated MAP Kinases - physiology Fatty Acids - analysis Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic - drug effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Inflammation - prevention & control Lipopolysaccharides - antagonists & inhibitors Macrophages - metabolism Male Mice Mice, Inbred C3H p38 Mitogen-Activated Protein Kinases - physiology PPAR alpha - drug effects PPAR gamma - drug effects PPAR gamma - physiology Prostaglandin D2 - analogs & derivatives Prostaglandin D2 - analysis Signal Transduction Vertebrates: cardiovascular system
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