Protein-Tyrosine Kinase Syk Expressed in Human Nasal Fibroblasts and Its Effect on RANTES Production

Fibroblasts, a rich source of chemokines, interact with eosinophils and play a key role in the pathogenesis of airway disease. RANTES is produced by fibroblasts to attract and activate eosinophils. LPS is known to induce RANTES and cause protein tyrosine phosphorylation. Nonreceptor protein tyrosine...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-01, Vol.166 (1), p.538-543
Hauptverfasser:	Yamada, Takechiyo, Fujieda, Shigeharu, Yanagi, Shigeru, Yamamura, Hirohei, Inatome, Ryoko, Sunaga, Hiroshi, Saito, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Cell Line Chemokine CCL5 - biosynthesis Enzyme Activation - genetics Enzyme Precursors - antagonists & inhibitors Enzyme Precursors - biosynthesis Enzyme Precursors - genetics Enzyme Precursors - metabolism Fibroblasts - enzymology Fibroblasts - metabolism Genetic Vectors - genetics Humans Intracellular Signaling Peptides and Proteins Lipopolysaccharides - pharmacology Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinases - metabolism Nasal Polyps - enzymology Nasal Polyps - metabolism Oligodeoxyribonucleotides, Antisense - pharmacology Phosphorylation Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - biosynthesis Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism RANTES Syk Kinase Syk protein Thionucleotides - pharmacology Transfection
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