Selective upregulation and amplification of the lysyl oxidase like-4 (LOXL4) gene in head and neck squamous cell carcinoma

Members of the lysyl oxidase family (LOX) are copper and lysyl‐tyrosine quinone cofactor‐containing amine oxidases that are important for the assembly and maintenance of components of the extracellular matrix. Our previous results demonstrated that a novel member, LOXL4, is overexpressed in head and...

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Veröffentlicht in:	The Journal of pathology 2007-05, Vol.212 (1), p.74-82
Hauptverfasser:	Görögh, T, Weise, JB, Holtmeier, C, Rudolph, P, Hedderich, J, Gottschlich, S, Hoffmann, M, Ambrosch, P, Csiszar, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Amino Acid Oxidoreductases - genetics Amino Acid Oxidoreductases - metabolism Biological and medical sciences Blotting, Northern - methods Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - secondary Case-Control Studies Cell Line, Tumor chromosomal localization Chromosomes, Human, Pair 10 Cytogenetic Analysis Enzyme Activation Extracellular Matrix - enzymology Female gene structure head and neck carcinoma Head and Neck Neoplasms - enzymology Head and Neck Neoplasms - genetics Humans Immunohistochemistry - methods In Situ Hybridization, Fluorescence Investigative techniques, diagnostic techniques (general aspects) LOXL4 expression Male Medical sciences Middle Aged Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Tumors Up-Regulation
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