Monoclonal TCR-Vbeta13.1+/CD4+/NKa+/CD8-/+dim T-LGL lymphocytosis: evidence for an antigen-driven chronic T-cell stimulation origin

Monoclonal TCRalphabeta(+)/CD4+ T-large granular lymphocyte (T-LGL) lymphocytosis is a T-cell disorder with a restricted TCR-Vbeta repertoire. In the present study we explored the potential association between the expanded TCR-Vbeta families, the CDR3 sequences of the TCR-Vbeta gene, and the HLA gen...

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Veröffentlicht in:	Blood 2007-06, Vol.109 (11), p.4890-4898
Hauptverfasser:	Garrido, Pilar, Ruiz-Cabello, Francisco, Bárcena, Paloma, Sandberg, Yorick, Cantón, Julia, Lima, Margarida, Balanzategui, Ana, González, Marcos, López-Nevot, Miguel Angel, Langerak, Anton W, García-Montero, Andrés C, Almeida, Julia, Orfao, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies, Monoclonal - chemistry CD4 Antigens - biosynthesis CD8 Antigens - biosynthesis Female Humans Lymphocytosis - immunology Male Middle Aged Peptide Fragments - chemistry Receptors, Antigen, T-Cell - metabolism Receptors, Antigen, T-Cell, alpha-beta - chemistry T-Lymphocytes - immunology
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