Genotypes of vitamin K epoxide reductase, γ-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients

Abstract The dose required for the anticoagulant effect of warfarin exhibits large inter-individual variations. This study sought to determine the contribution of four genes, vitamin K epoxide reductase ( VKORC1 ), γ-glutamyl carboxylase ( GGCX ), calumenin ( CALU ), and cytochrome P450 2C9 ( CYP2C9...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Thrombosis research 2007, Vol.120 (2), p.181-186
Hauptverfasser:	Kimura, Rina, Miyashita, Kotaro, Kokubo, Yoshihiro, Akaiwa, Yasuhisa, Otsubo, Ryoichi, Nagatsuka, Kazuyuki, Otsuki, Toshiho, Okayama, Akira, Minematsu, Kazuo, Naritomi, Hiroaki, Honda, Shigenori, Tomoike, Hitonobu, Miyata, Toshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anticoagulants - administration & dosage Aryl Hydrocarbon Hydroxylases - genetics Biological and medical sciences Blood and lymphatic vessels Carbon-Carbon Ligases - genetics Cardiology. Vascular system Cardiovascular system CYP2C9 Cytochrome P-450 CYP2C9 Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female General and cellular metabolism. Vitamins Genetic polymorphisms Genotype GGCX Hematology, Oncology and Palliative Medicine Humans Japan Male Medical sciences Middle Aged Mixed Function Oxygenases - genetics Models, Biological Pharmacogenetics Pharmacology. Drug treatments Polymorphism, Single Nucleotide Regression Analysis Stroke - drug therapy Stroke - genetics Vasodilator agents. Cerebral vasodilators Vitamin K Epoxide Reductases VKORC1 Warfarin Warfarin - administration & dosage
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!