Isolation of new phenylacetylingol derivatives that reactivate HIV-1 latency and a novel spirotriterpenoid from Euphorbia officinarum latex

The biological effects of new ingol diterpenes ( 1– 3) on cell cycle and HIV-1 gene transcription were analysed. Compound 3 induced cell-cycle arrest and HIV-1-LTR promoter activation. Three new, highly functionalized ingol diterpenes, ingol 7,8,12-triacetate 3-phenylacetate ( 1), ingol 7,8,12-triac...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2007-07, Vol.15 (13), p.4577-4584
Hauptverfasser:	Daoubi, Mourad, Marquez, Nieves, Mazoir, Noureddine, Benharref, Ahmed, Hernández-Galán, Rosario, Muñoz, Eduardo, Collado, Isidro G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell cycle Cell Cycle - drug effects Crystallography, X-Ray Diterpenes - isolation & purification Diterpenes - pharmacology Diterpenoids Euphorbia - chemistry Euphorbia officinarum Euphorbiaceae Flow Cytometry Gene Expression Regulation, Viral - drug effects General pharmacology HIV-1 - drug effects HIV-1 - genetics HIV-1 latency Humans Indicators and Reagents Ingol esters Jurkat Cells Latex - chemistry Magnetic Resonance Spectroscopy Medical sciences Models, Molecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenylacetates - isolation & purification Phenylacetates - pharmacology Spectroscopy, Fourier Transform Infrared Spiro Compounds - isolation & purification Spiro Compounds - pharmacology Spiro-triterpenoids Triterpenes - isolation & purification Triterpenes - pharmacology Virus Latency - drug effects
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