Oral administration of candesartan improves the survival of mice with viral myocarditis through modification of cardiac adiponectin expression

We examined the effects of the angiotensin II receptor type 1 blocker candesartan on myocarditis injury in a murine model of acute myocarditis. We hypothesized that candesartan improves cardiac damage by inducing cardiac expression of adiponectin. We examined changes in heart failure caused by myoca...

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Veröffentlicht in:	Cardiovascular drugs and therapy 2007-06, Vol.21 (3), p.155-160
Hauptverfasser:	SAEGUSA, Seiichiro, YU FEI, IWAI, Kunimitsu, MATSUMOTO, Masayuki, KANDA, Tsugiyasu, TAKAHASHI, Takashi, SUMINO, Hiroyuki, MORIYA, Junji, KAWAURA, Ken, YAMAKAWA, Jun-Ichi, ITOH, Tohoru, MORIMOTO, Shigeto, NAKAHASHI, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin Adiponectin - genetics Adiponectin - metabolism Administration, Oral Angiotensin Angiotensin II Angiotensin II Type 1 Receptor Blockers - administration & dosage Angiotensin II Type 1 Receptor Blockers - pharmacology Animal models Animals Benzimidazoles - administration & dosage Benzimidazoles - pharmacology Benzimidazoles - therapeutic use Biological and medical sciences Body weight Cardiology. Vascular system Cardiovascular system Congestive heart failure Damage Disease Models, Animal Encephalomyocarditis virus Female Gene expression Gene Expression - drug effects Heart Heart - virology Heart diseases Heart failure Heart failure, cardiogenic pulmonary edema, cardiac enlargement Hybridization Immunohistochemistry In Situ Hybridization Male Medical sciences Mice Mice, Inbred C3H mRNA Myocarditis Myocarditis - mortality Myocarditis - pathology Myocarditis - prevention & control Myocarditis. Cardiomyopathies Myocardium - metabolism Myocardium - pathology Oral administration Organ Size - drug effects Pharmacology. Drug treatments Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Survival Survival Rate Tetrazoles - administration & dosage Tetrazoles - pharmacology Tetrazoles - therapeutic use Time Factors Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Virus Diseases - mortality Virus Diseases - pathology Virus Diseases - prevention & control Viruses Weight Gain - drug effects
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