A new model of corneal transplantation in the miniature pig: Efficacy of immunosuppressive treatment
Corneal allograft rejection is frequently studied in small rodent or rabbit models. To study mechanisms of rejection in a model that more closely mimics transplantation in humans, we performed orthotopic corneal transplantation in the miniature pig using a 7-mm diameter donor graft. Four groups of r...
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| Veröffentlicht in: | Transplantation 2007-05, Vol.83 (10), p.1401-1403 |
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| creator | TAVANDZI, Urania PROCHDZKA, Radek USVALD, Dusan HLUCILOVA, Jana VITASKOVA, Martina MOTLIK, Jan VITOVA, Andrea FILIPEC, Martin FORRESTER, John V HOLAN, Vladimir |
| description | Corneal allograft rejection is frequently studied in small rodent or rabbit models. To study mechanisms of rejection in a model that more closely mimics transplantation in humans, we performed orthotopic corneal transplantation in the miniature pig using a 7-mm diameter donor graft. Four groups of recipients were studied: 1) untreated naive, 2) untreated vascularized (high risk), 3) high-risk grafts treated by topical application of prednisolone, or 4) high-risk grafts treated with a combined systemic immunosuppression regime of oral prednisone, cyclosporine A, and mycophenolate mofetil. Both the clinical features and histological assessment of corneal graft rejection showed close similarities to graft rejection in humans. Interestingly, preliminary results indicated that topical steroid treatment was superior to systemic immunosuppression in significantly promoting graft survival. Thus, corneal transplantation in the pig represents an animal model most closely resembling corneal grafting in humans, and offers possibilities for testing various clinically applicable immunosuppressive treatments. |
| doi_str_mv | 10.1097/01.tp.0000261711.08833.a1 |
| format | Article |
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To study mechanisms of rejection in a model that more closely mimics transplantation in humans, we performed orthotopic corneal transplantation in the miniature pig using a 7-mm diameter donor graft. Four groups of recipients were studied: 1) untreated naive, 2) untreated vascularized (high risk), 3) high-risk grafts treated by topical application of prednisolone, or 4) high-risk grafts treated with a combined systemic immunosuppression regime of oral prednisone, cyclosporine A, and mycophenolate mofetil. Both the clinical features and histological assessment of corneal graft rejection showed close similarities to graft rejection in humans. Interestingly, preliminary results indicated that topical steroid treatment was superior to systemic immunosuppression in significantly promoting graft survival. Thus, corneal transplantation in the pig represents an animal model most closely resembling corneal grafting in humans, and offers possibilities for testing various clinically applicable immunosuppressive treatments.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/01.tp.0000261711.08833.a1</identifier><identifier>PMID: 17519795</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Animals ; Biological and medical sciences ; Corneal Transplantation - immunology ; Corneal Transplantation - methods ; Drug Therapy, Combination ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Graft Rejection - prevention & control ; Graft Survival - drug effects ; Immunosuppressive Agents - therapeutic use ; Medical sciences ; Models, Animal ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Swine ; Swine, Miniature ; Tissue, organ and graft immunology</subject><ispartof>Transplantation, 2007-05, Vol.83 (10), p.1401-1403</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-dd649609c4c7c38be07f3ddb7afb827784ff576252ba9083def26eb7ec53047d3</citedby><cites>FETCH-LOGICAL-c458t-dd649609c4c7c38be07f3ddb7afb827784ff576252ba9083def26eb7ec53047d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18798042$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17519795$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TAVANDZI, Urania</creatorcontrib><creatorcontrib>PROCHDZKA, Radek</creatorcontrib><creatorcontrib>USVALD, Dusan</creatorcontrib><creatorcontrib>HLUCILOVA, Jana</creatorcontrib><creatorcontrib>VITASKOVA, Martina</creatorcontrib><creatorcontrib>MOTLIK, Jan</creatorcontrib><creatorcontrib>VITOVA, Andrea</creatorcontrib><creatorcontrib>FILIPEC, Martin</creatorcontrib><creatorcontrib>FORRESTER, John V</creatorcontrib><creatorcontrib>HOLAN, Vladimir</creatorcontrib><title>A new model of corneal transplantation in the miniature pig: Efficacy of immunosuppressive treatment</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Corneal allograft rejection is frequently studied in small rodent or rabbit models. To study mechanisms of rejection in a model that more closely mimics transplantation in humans, we performed orthotopic corneal transplantation in the miniature pig using a 7-mm diameter donor graft. Four groups of recipients were studied: 1) untreated naive, 2) untreated vascularized (high risk), 3) high-risk grafts treated by topical application of prednisolone, or 4) high-risk grafts treated with a combined systemic immunosuppression regime of oral prednisone, cyclosporine A, and mycophenolate mofetil. Both the clinical features and histological assessment of corneal graft rejection showed close similarities to graft rejection in humans. Interestingly, preliminary results indicated that topical steroid treatment was superior to systemic immunosuppression in significantly promoting graft survival. Thus, corneal transplantation in the pig represents an animal model most closely resembling corneal grafting in humans, and offers possibilities for testing various clinically applicable immunosuppressive treatments.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Corneal Transplantation - immunology</subject><subject>Corneal Transplantation - methods</subject><subject>Drug Therapy, Combination</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Graft Rejection - prevention & control</subject><subject>Graft Survival - drug effects</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Medical sciences</subject><subject>Models, Animal</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Swine</subject><subject>Swine, Miniature</subject><subject>Tissue, organ and graft immunology</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQRi0EopeWV0BmQXcJ49jxD7uqagGpEhu6thx7DEaJE2IH1LcnpVe6y85mNuf7RqNDyHsGLQOjPgJr69LCPp1kirEWtOa8dewFObCei0aChpfkACBYwzhXZ-RNKb92vudKvSZnTPXMKNMfSLiiGf_SaQ440jlSP68Z3Ujr6nJZRperq2nONGVafyKdUk6ubivSJf34RG9iTN75h8dkmqYtz2VblhVLSX9w70BXJ8z1gryKbiz49rjPyf3tzffrL83dt89fr6_uGi96XZsQpDASjBdeea4HBBV5CINycdCdUlrE2CvZ9d3gDGgeMHYSB4W-5yBU4Ofk8ql3WeffG5Zqp1Q8jvsbOG_FKug7AQaeBTuQUkgjngWZkQYE5ztonkC_zqWsGO2ypsmtD5aBfZRmgdm62JM0-1-adWzPvjse2YYJwyl5tLQDH46AK96NcXfjUzlxWhkNouP_ADwSodA</recordid><startdate>20070527</startdate><enddate>20070527</enddate><creator>TAVANDZI, Urania</creator><creator>PROCHDZKA, Radek</creator><creator>USVALD, Dusan</creator><creator>HLUCILOVA, Jana</creator><creator>VITASKOVA, Martina</creator><creator>MOTLIK, Jan</creator><creator>VITOVA, Andrea</creator><creator>FILIPEC, Martin</creator><creator>FORRESTER, John V</creator><creator>HOLAN, Vladimir</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070527</creationdate><title>A new model of corneal transplantation in the miniature pig: Efficacy of immunosuppressive treatment</title><author>TAVANDZI, Urania ; PROCHDZKA, Radek ; USVALD, Dusan ; HLUCILOVA, Jana ; VITASKOVA, Martina ; MOTLIK, Jan ; VITOVA, Andrea ; FILIPEC, Martin ; FORRESTER, John V ; HOLAN, Vladimir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-dd649609c4c7c38be07f3ddb7afb827784ff576252ba9083def26eb7ec53047d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Corneal Transplantation - immunology</topic><topic>Corneal Transplantation - methods</topic><topic>Drug Therapy, Combination</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Graft Rejection - prevention & control</topic><topic>Graft Survival - drug effects</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Medical sciences</topic><topic>Models, Animal</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Swine</topic><topic>Swine, Miniature</topic><topic>Tissue, organ and graft immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TAVANDZI, Urania</creatorcontrib><creatorcontrib>PROCHDZKA, Radek</creatorcontrib><creatorcontrib>USVALD, Dusan</creatorcontrib><creatorcontrib>HLUCILOVA, Jana</creatorcontrib><creatorcontrib>VITASKOVA, Martina</creatorcontrib><creatorcontrib>MOTLIK, Jan</creatorcontrib><creatorcontrib>VITOVA, Andrea</creatorcontrib><creatorcontrib>FILIPEC, Martin</creatorcontrib><creatorcontrib>FORRESTER, John V</creatorcontrib><creatorcontrib>HOLAN, Vladimir</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TAVANDZI, Urania</au><au>PROCHDZKA, Radek</au><au>USVALD, Dusan</au><au>HLUCILOVA, Jana</au><au>VITASKOVA, Martina</au><au>MOTLIK, Jan</au><au>VITOVA, Andrea</au><au>FILIPEC, Martin</au><au>FORRESTER, John V</au><au>HOLAN, Vladimir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new model of corneal transplantation in the miniature pig: Efficacy of immunosuppressive treatment</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2007-05-27</date><risdate>2007</risdate><volume>83</volume><issue>10</issue><spage>1401</spage><epage>1403</epage><pages>1401-1403</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Corneal allograft rejection is frequently studied in small rodent or rabbit models. To study mechanisms of rejection in a model that more closely mimics transplantation in humans, we performed orthotopic corneal transplantation in the miniature pig using a 7-mm diameter donor graft. Four groups of recipients were studied: 1) untreated naive, 2) untreated vascularized (high risk), 3) high-risk grafts treated by topical application of prednisolone, or 4) high-risk grafts treated with a combined systemic immunosuppression regime of oral prednisone, cyclosporine A, and mycophenolate mofetil. Both the clinical features and histological assessment of corneal graft rejection showed close similarities to graft rejection in humans. Interestingly, preliminary results indicated that topical steroid treatment was superior to systemic immunosuppression in significantly promoting graft survival. Thus, corneal transplantation in the pig represents an animal model most closely resembling corneal grafting in humans, and offers possibilities for testing various clinically applicable immunosuppressive treatments.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>17519795</pmid><doi>10.1097/01.tp.0000261711.08833.a1</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences Corneal Transplantation - immunology Corneal Transplantation - methods Drug Therapy, Combination Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Rejection - prevention & control Graft Survival - drug effects Immunosuppressive Agents - therapeutic use Medical sciences Models, Animal Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Swine Swine, Miniature Tissue, organ and graft immunology |
| title | A new model of corneal transplantation in the miniature pig: Efficacy of immunosuppressive treatment |
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