Synergistic activation of the tumor suppressor, HLJ1, by the transcription factors YY1 and activator protein 1

HLJ1 is a novel tumor and invasion suppressor that inhibits tumorigenesis and cancer metastasis. However, the mechanism of HLJ1 activation is currently unclear. Here, we identify an enhancer segment in the HLJ1 gene at -2,125 to -1,039 bp upstream of the transcription start site. A 50-bp element bet...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-05, Vol.67 (10), p.4816-4826
Hauptverfasser:	WANG, Chi-Chung, TSAI, Meng-Feng, DAI, Ting-Hao, HONG, Tse-Ming, CHAN, Wing-Kai, CHEN, Jeremy J. W, YANG, Pan-Chyr
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Antineoplastic agents Base Sequence Biological and medical sciences Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Cell Line, Tumor Enhancer Elements, Genetic Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor HSP40 Heat-Shock Proteins - biosynthesis HSP40 Heat-Shock Proteins - genetics HSP40 Heat-Shock Proteins - metabolism Humans Liver Neoplasms - genetics Liver Neoplasms - metabolism Lung Neoplasms - genetics Lung Neoplasms - metabolism Medical sciences Molecular Sequence Data Pharmacology. Drug treatments Promoter Regions, Genetic Proto-Oncogene Proteins c-fos - biosynthesis Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-jun - biosynthesis Proto-Oncogene Proteins c-jun - genetics Transcription Factor AP-1 - genetics Transcription Factor AP-1 - metabolism Transcriptional Activation Transfection Tumors Up-Regulation YY1 Transcription Factor - biosynthesis YY1 Transcription Factor - genetics YY1 Transcription Factor - metabolism
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